ID   HMDH_HALVO              Reviewed;         403 AA.
AC   Q59468;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 51.
DE   RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase;
DE            Short=HMG-CoA reductase;
DE            EC=1.1.1.34;
GN   Name=hmgA; Synonyms=hmg;
OS   Halobacterium volcanii (Haloferax volcanii).
OC   Archaea; Euryarchaeota; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Haloferax.
OX   NCBI_TaxID=2246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WFD11;
RX   MEDLINE=92210542; PubMed=1556098;
RA   Lam W.L., Doolittle W.F.;
RT   "Mevinolin-resistant mutations identify a promoter and the gene for a
RT   eukaryote-like 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the
RT   archaebacterium Haloferax volcanii.";
RL   J. Biol. Chem. 267:5829-5834(1992).
CC   -!- FUNCTION: Converts HMG-CoA to mevalonate (By similarity).
CC   -!- CATALYTIC ACTIVITY: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-
CC       hydroxy-3-methylglutaryl-CoA + 2 NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; mevalonic acid
CC       biosynthesis; (R)-mevalonic acid from acetyl-CoA: step 3/3.
CC   -!- INDUCTION: Inhibited by mevinolin.
CC   -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
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DR   EMBL; M83531; AAA73174.1; -; Genomic_DNA.
DR   PIR; A42149; A42149.
DR   HSSP; P04035; 1HW8.
DR   BRENDA; 1.1.1.34; 430.
DR   GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR   GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH)...; IEA:EC.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002202; HMG_CoA_Rdtase_cat.
DR   InterPro; IPR004554; HMG_CoA_Rdtase_I_cat.
DR   PANTHER; PTHR10572; HMG-CoA_red; 1.
DR   Pfam; PF00368; HMG-CoA_red; 1.
DR   PRINTS; PR00071; HMGCOARDTASE.
DR   TIGRFAMs; TIGR00533; HMG_CoA_R_NADP; 1.
DR   PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR   PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR   PROSITE; PS01192; HMG_COA_REDUCTASE_3; FALSE_NEG.
DR   PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE   2: Evidence at transcript level;
KW   Isoprene biosynthesis; NADP; Oxidoreductase.
FT   CHAIN         1    403       3-hydroxy-3-methylglutaryl-coenzyme A
FT                                reductase.
FT                                /FTId=PRO_0000114460.
FT   ACT_SITE     99     99       Charge relay system (By similarity).
FT   ACT_SITE    303    303       Charge relay system (By similarity).
FT   ACT_SITE    398    398       Proton donor (By similarity).
SQ   SEQUENCE   403 AA;  41213 MW;  7EB79919587BD724 CRC64;
     MTDAASLADR VREGDLRLHE LEAHADADTA AEARRLLVES QSGASLDAVG NYGFPAEAAE
     SAIENMVGSI QVPMGVAGPV SVDGGSVAGE KYLPLATTEG ALLASVNRGC SVINSAGGAT
     ARVLKSGMTR APVFRVADVA EAEALVSWTR DNFAALKEAA EETTNHGELL DVTPYVVGNS
     VYLRFRYDTK DAMGMNMATI ATEAVCGVVE AETAASLVAL SGNLCSDKKP AAINAVEGRG
     RSVTADVRIP REVVEERLHT TPERGRELNT RKNLVGSAKA ASLGFNAHVA NVVAAMFLAT
     GQDEAQVVEG ANAITTAEVQ DGDLYVSVSI ASLEVGTVGG GTKLPTQSEG LDILGVSGGG
     DPAGSNADAL AECIAVGSLA GELSLLSALA SRHLSSAHAE LGR
//