Reviewed,
UniProtKB/Swiss-Prot Q59468 (HMDH_HALVO)
Last modified
February 9, 2010.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase Short name=HMG-CoA reductase EC=1.1.1.34 | ||||
| Gene names |
| ||||
| Organism | Halobacterium volcanii (Haloferax volcanii) | ||||
| Taxonomic identifier | 2246 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloferax |
Protein attributes
| Sequence length | 403 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Converts HMG-CoA to mevalonate By similarity. |
| Catalytic activity | (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH. |
| Pathway | |
| Induction | Inhibited by mevinolin. |
| Sequence similarities | Belongs to the HMG-CoA reductase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Isoprene biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | coenzyme A metabolic process Inferred from electronic annotation. Source: InterPro isoprenoid biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: InterPro |
| Molecular function | NADP or NADPH binding Inferred from electronic annotation. Source: InterPro hydroxymethylglutaryl-CoA reductase (NADPH) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 403 | 403 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | PRO_0000114460 | |||||
Sites | |||||||||
| Active site | 99 | 1 | Charge relay system By similarity | ||||||
| Active site | 303 | 1 | Charge relay system By similarity | ||||||
| Active site | 398 | 1 | Proton donor By similarity | ||||||
Sequences
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References
| [1] | "Mevinolin-resistant mutations identify a promoter and the gene for a eukaryote-like 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the archaebacterium Haloferax volcanii." Lam W.L., Doolittle W.F. J. Biol. Chem. 267:5829-5834(1992) [PubMed: 1556098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WFD11. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M83531 Genomic DNA. Translation: AAA73174.1. |
| PIR | A42149. |
3D structure databases | |
| SMR | Q59468. Positions 7-394. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.34. 430. |
Family and domain databases | |
| InterPro | IPR002202. HMG_CoA_Rdtase_cat. IPR004554. HMG_CoA_Rdtase_I_cat. IPR009023. HMG_CoA_Rdtase_NAD(P)-bd. IPR009029. HMG_CoA_Rdtase_sub-bd. [Graphical view] |
| PANTHER | PTHR10572. HMG-CoA_red. 1 hit. |
| Pfam | PF00368. HMG-CoA_red. 1 hit. [Graphical view] |
| PRINTS | PR00071. HMGCOARDTASE. |
| TIGRFAMs | TIGR00533. HMG_CoA_R_NADP. 1 hit. |
| PROSITE | PS00066. HMG_COA_REDUCTASE_1. 1 hit. PS00318. HMG_COA_REDUCTASE_2. 1 hit. PS01192. HMG_COA_REDUCTASE_3. False negative. PS50065. HMG_COA_REDUCTASE_4. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HMDH_HALVO | ||||||||
| Accession | Primary (citable) accession number: Q59468 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


