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Protein

Copper-transporting ATPase

Gene

copA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Probably involved in copper export.

Catalytic activityi

ATP + H2O + Cu2+(Side 1) = ADP + phosphate + Cu2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12CopperPROSITE-ProRule annotation1
Metal bindingi15CopperPROSITE-ProRule annotation1
Active sitei4314-aspartylphosphate intermediateBy similarity1
Metal bindingi627MagnesiumPROSITE-ProRule annotation1
Metal bindingi631MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • copper ion transport Source: CACAO

Keywordsi

Molecular functionHydrolase
Biological processCopper transport, Ion transport, Transport
LigandATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase (EC:3.6.3.4)
Gene namesi
Name:copA
OrganismiHelicobacter pylori (Campylobacter pylori)
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 83CytoplasmicSequence analysisAdd BLAST83
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 124ExtracellularSequence analysisAdd BLAST20
Transmembranei125 – 144HelicalSequence analysisAdd BLAST20
Topological domaini145 – 151CytoplasmicSequence analysis7
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 190ExtracellularSequence analysisAdd BLAST18
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 339CytoplasmicSequence analysisAdd BLAST128
Transmembranei340 – 362HelicalSequence analysisAdd BLAST23
Topological domaini363 – 375ExtracellularSequence analysisAdd BLAST13
Transmembranei376 – 393HelicalSequence analysisAdd BLAST18
Topological domaini394 – 681CytoplasmicSequence analysisAdd BLAST288
Transmembranei682 – 701HelicalSequence analysisAdd BLAST20
Topological domaini702 – 712ExtracellularSequence analysisAdd BLAST11
Transmembranei713 – 731HelicalSequence analysisAdd BLAST19
Topological domaini732 – 741CytoplasmicSequence analysis10

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461721 – 741Copper-transporting ATPaseAdd BLAST741

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ59467.
SMRiQ59467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 68HMAPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di3.40.1110.10. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00403. HMA. 1 hit.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKESFYIEGM TCTACSSGIE RSLGRKSFVK KIEVSLLNKS ANIEFNENET
60 70 80 90 100
NLDEIFKLIE KLGYSPKKTL AEEKKEFFSP NVKLALAVIF TLFVVYLSMG
110 120 130 140 150
AMLSPSLLPE SLLTINNHSN FLNACLQLIG TLIVMHLGRD FYIQGFKALW
160 170 180 190 200
HRQPNMSSLI AIGTSAALIS SLWQLYFVYT SQWSYGHYYF ESVCVILMFV
210 220 230 240 250
MVGKRIENVS KDKALDAMQA LMKNAPKTAL KMHNNQQIEV LVDSIVVGDI
260 270 280 290 300
LKVLPGSAIA VDGEIIEGEG ELDESMLSGE ALPVYKKVGD KVFSGTFNSH
310 320 330 340 350
TSFLMKATQD NKNSTLSQIV EMIHNAQSSK AEISRLADKV SSVFVPSVIA
360 370 380 390 400
IAILAFVVWL IIAPKPDFWW NFGIALEVFV SVLVISCPCA LGLATPMSIL
410 420 430 440 450
VANQKASSLG LFFKDAKSLE KARLVNTIVF DKTGTLTNGK PVVKSVHSNI
460 470 480 490 500
ELLELLSLAG SIEKSSEHVI AKGIVEYAKE HNAPLKEMSE VKVKTGFGIS
510 520 530 540 550
AKTDYQGAKE VIKVGNSEFF NPINALEIQE NGILVFVGRV ISEKEDELLG
560 570 580 590 600
AFVLEDLPKK GVKEHIAQIK KLGINTFLLS GDNRENVKKC ALELGIDGYI
610 620 630 640 650
SNAKPQDKLN KIKELKEKGQ IVMMVGDGLN DAPSLAMSDV AVVMAKGSDV
660 670 680 690 700
SVQAADIVSF NNDIKSVYSA IKLSQATIKN IKENLFWAFC YNSVFIPLAC
710 720 730 740
GVLYKANIML SPAIAGLAMS LSSVSVVLNS QRLRNFKIKD H
Length:741
Mass (Da):81,293
Last modified:November 1, 1996 - v1
Checksum:iD1FDEAD11E149DAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59625 Genomic DNA. Translation: AAB05475.1.

Similar proteinsi

Entry informationi

Entry nameiCOPA2_HELPX
AccessioniPrimary (citable) accession number: Q59467
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families