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Reviewed, UniProtKB/Swiss-Prot Q59467 (COPA2_HELPY)

Last modified October 13, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Copper-transporting ATPase
    EC=3.6.3.4
Gene names
Name: copA
OrganismHelicobacter pylori (Campylobacter pylori)
Taxonomic identifier210 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

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Protein attributes

Sequence length741 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Probably involved in copper export.

Catalytic activity

ATP + H2O + Cu2+(In) = ADP + phosphate + Cu2+(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. Type IB subfamily.

Contains 1 HMA domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 741741Copper-transporting ATPase
PRO_0000046172

Regions

Topological domain1 – 8383Cytoplasmic Potential
Transmembrane84 – 10421 Potential
Topological domain105 – 12420Extracellular Potential
Transmembrane125 – 14420 Potential
Topological domain145 – 1517Cytoplasmic Potential
Transmembrane152 – 17221 Potential
Topological domain173 – 19018Extracellular Potential
Transmembrane191 – 21121 Potential
Topological domain212 – 339128Cytoplasmic Potential
Transmembrane340 – 36223 Potential
Topological domain363 – 37513Extracellular Potential
Transmembrane376 – 39318 Potential
Topological domain394 – 681288Cytoplasmic Potential
Transmembrane682 – 70120 Potential
Topological domain702 – 71211Extracellular Potential
Transmembrane713 – 73119 Potential
Topological domain732 – 74110Cytoplasmic Potential
Domain2 – 6867HMA

Sites

Active site43114-aspartylphosphate intermediate By similarity
Metal binding121Copper Potential
Metal binding151Copper Potential
Metal binding6271Magnesium By similarity
Metal binding6311Magnesium By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q59467-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D1FDEAD11E149DAA

FASTA74181,293
        10         20         30         40         50         60 
MKESFYIEGM TCTACSSGIE RSLGRKSFVK KIEVSLLNKS ANIEFNENET NLDEIFKLIE 

        70         80         90        100        110        120 
KLGYSPKKTL AEEKKEFFSP NVKLALAVIF TLFVVYLSMG AMLSPSLLPE SLLTINNHSN 

       130        140        150        160        170        180 
FLNACLQLIG TLIVMHLGRD FYIQGFKALW HRQPNMSSLI AIGTSAALIS SLWQLYFVYT 

       190        200        210        220        230        240 
SQWSYGHYYF ESVCVILMFV MVGKRIENVS KDKALDAMQA LMKNAPKTAL KMHNNQQIEV 

       250        260        270        280        290        300 
LVDSIVVGDI LKVLPGSAIA VDGEIIEGEG ELDESMLSGE ALPVYKKVGD KVFSGTFNSH 

       310        320        330        340        350        360 
TSFLMKATQD NKNSTLSQIV EMIHNAQSSK AEISRLADKV SSVFVPSVIA IAILAFVVWL 

       370        380        390        400        410        420 
IIAPKPDFWW NFGIALEVFV SVLVISCPCA LGLATPMSIL VANQKASSLG LFFKDAKSLE 

       430        440        450        460        470        480 
KARLVNTIVF DKTGTLTNGK PVVKSVHSNI ELLELLSLAG SIEKSSEHVI AKGIVEYAKE 

       490        500        510        520        530        540 
HNAPLKEMSE VKVKTGFGIS AKTDYQGAKE VIKVGNSEFF NPINALEIQE NGILVFVGRV 

       550        560        570        580        590        600 
ISEKEDELLG AFVLEDLPKK GVKEHIAQIK KLGINTFLLS GDNRENVKKC ALELGIDGYI 

       610        620        630        640        650        660 
SNAKPQDKLN KIKELKEKGQ IVMMVGDGLN DAPSLAMSDV AVVMAKGSDV SVQAADIVSF 

       670        680        690        700        710        720 
NNDIKSVYSA IKLSQATIKN IKENLFWAFC YNSVFIPLAC GVLYKANIML SPAIAGLAMS 

       730        740 
LSSVSVVLNS QRLRNFKIKD H

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References

[1]"Properties of the P-type ATPases encoded by the copAP operons of Helicobacter pylori and Helicobacter felis."
Bayle D., Waengler S., Weitzenegger T., Steinhilber W., Volz J., Przybylski M., Schaefer K.P., Sachs G., Melchers K.
J. Bacteriol. 180:317-329(1998) [PubMed: 9440521] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: A68.

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Cross-references

Sequence databases

U59625 Genomic DNA. Translation: AAB05475.1.

3D structure databases

HSSPHSSP built from PDB template 1CPZ based on UniProtKB Q47840.
ModBaseSearch...

Enzyme and pathway databases

BRENDA3.6.3.4. 1131.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-reg.
IPR006403. ATPase_P-typ_cat/Cu-transptr.
IPR001756. ATPase_P-typ_Cu-transptr.
IPR006416. ATPase_P-typ_heavy-metal.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR005834. Dehalogen-like_hydro.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe_transpt.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00943. CUATPASE.
TIGRFAMsTIGR01511. ATPase-IB1_Cu. 1 hit.
TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCOPA2_HELPY
AccessionPrimary (citable) accession number: Q59467
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 13, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents