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Q59337

- CATA_DEIRA

UniProt

Q59337 - CATA_DEIRA

Protein

Catalase

Gene

katA

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.1 Publication

    Catalytic activityi

    2 H2O2 = O2 + 2 H2O.

    Cofactori

    Heme group.1 Publication

    Enzyme regulationi

    Strongly inhibited by sodium azide and sodium cyanide, and sligthly inhibited by 3-amino-1,2,4-triazole.1 Publication

    Temperature dependencei

    Optimum temperature is 30 degrees Celsius. Active over a temperature range from 20 to 70 degrees Celsius. Retains 100% of its initial activity following incubation at 40 degrees Celsius, and 82% of its activity following incubation at 50 degrees Celsius. The activity decreases significantly to 30% of the initial activity following incubation at 60 degrees Celsius.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei81 – 811By similarity
    Active sitei159 – 1591By similarity
    Metal bindingi369 – 3691Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. catalase activity Source: CACAO
    2. heme binding Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. hydrogen peroxide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxide

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-2032-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Catalase (EC:1.11.1.6)
    Gene namesi
    Name:katA
    Ordered Locus Names:DR_1998
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 536536CatalasePRO_0000085014Add
    BLAST

    Proteomic databases

    PRIDEiQ59337.

    Expressioni

    Developmental stagei

    Up-regulated during stationary phase.1 Publication

    Interactioni

    Subunit structurei

    Homotetramer.1 Publication

    Protein-protein interaction databases

    STRINGi243230.DR_1998.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59337.
    SMRiQ59337. Positions 32-515.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the catalase family.Curated

    Phylogenomic databases

    eggNOGiCOG0753.
    HOGENOMiHOG000087852.
    KOiK03781.
    OMAiEATTMIM.
    OrthoDBiEOG6P5Z9F.

    Family and domain databases

    Gene3Di2.40.180.10. 1 hit.
    InterProiIPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view]
    PANTHERiPTHR11465. PTHR11465. 1 hit.
    PfamiPF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSiPR00067. CATALASE.
    SMARTiSM01060. Catalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56634. SSF56634. 1 hit.
    PROSITEiPS00437. CATALASE_1. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59337-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDENNKGVG TAVQGVGGPR DGRTAPGEQG TTLTTRQGHP VHDNQNSRTV    50
    GSRGPMTLEN YQFIEKLSHF DRERIPERVV HARGVGAHGV FRATGKVGDE 100
    PVSKYTRAKL FQEDGKETPV FVRFSTVGHG THSPETLRDP RGFAVKFYTE 150
    DGNWDLVGNN LKIFFIRDAL KFPDLIHSQK PSPTTNIQSQ ERIFDFFAGS 200
    PEATHMITLL YSPWGIPASY RFMQGSGVNT YKWVNDQGEG VLVKYHWEPV 250
    QGVRNLTQMQ ADEVQATNFN HATQDLHDAI ERGDFPQWDL FVQIMEDGEH 300
    PELDFDPLDD TKIWPREQFP WRHVGQMTLN RNPENVFAET EQAAFGTGVL 350
    VDGLDFSDDK MLQGRTFSYS DTQRYRVGPN YLQLPINAPK KHVATNQRDG 400
    QMAYRVDTFE GQDQRVNYEP SLLSGPKEAP RRAPEHTPRV EGNLVRAAIE 450
    RPNPFGQAGM QYRNFADWER DELVSNLSGA LAGVDKRIQD KMLEYFTAAD 500
    ADYGQRVREG IQAKEAEMKG QKQEAPVYGT EASSLY 536
    Length:536
    Mass (Da):60,513
    Last modified:May 30, 2000 - v2
    Checksum:i6A60CB6A8F445A59
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1521G → A in BAA09937. 1 PublicationCurated
    Sequence conflicti156 – 1583LVG → FVV in BAA09937. 1 PublicationCurated
    Sequence conflicti277 – 2771H → R in BAA09937. 1 PublicationCurated
    Sequence conflicti293 – 2931Q → K in BAA09937. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63898 Genomic DNA. Translation: BAA09937.1.
    AE000513 Genomic DNA. Translation: AAF11546.1.
    PIRiB75329.
    RefSeqiNP_295721.1. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF11546; AAF11546; DR_1998.
    GeneIDi1800077.
    KEGGidra:DR_1998.
    PATRICi21631656. VBIDeiRad64572_2221.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63898 Genomic DNA. Translation: BAA09937.1 .
    AE000513 Genomic DNA. Translation: AAF11546.1 .
    PIRi B75329.
    RefSeqi NP_295721.1. NC_001263.1.

    3D structure databases

    ProteinModelPortali Q59337.
    SMRi Q59337. Positions 32-515.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_1998.

    Proteomic databases

    PRIDEi Q59337.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF11546 ; AAF11546 ; DR_1998 .
    GeneIDi 1800077.
    KEGGi dra:DR_1998.
    PATRICi 21631656. VBIDeiRad64572_2221.

    Phylogenomic databases

    eggNOGi COG0753.
    HOGENOMi HOG000087852.
    KOi K03781.
    OMAi EATTMIM.
    OrthoDBi EOG6P5Z9F.

    Enzyme and pathway databases

    BioCyci DRAD243230:GH46-2032-MONOMER.

    Family and domain databases

    Gene3Di 2.40.180.10. 1 hit.
    InterProi IPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view ]
    PANTHERi PTHR11465. PTHR11465. 1 hit.
    Pfami PF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSi PR00067. CATALASE.
    SMARTi SM01060. Catalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56634. SSF56634. 1 hit.
    PROSITEi PS00437. CATALASE_1. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and nucleotide sequence of radiation-inducible catalase gene from radioresistant bacterium, Deinococcus radiodurans."
      Narumi I., Watanabe H., Hossain A., Tanaka A., Kitayama S.
      Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    3. "Induction of resistance to hydrogen peroxide and radiation in Deinococcus radiodurans."
      Wang P., Schellhorn H.E.
      Can. J. Microbiol. 41:170-176(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    4. "Characterization of monofunctional catalase KatA from radioresistant bacterium Deinococcus radiodurans."
      Kobayashi I., Tamura T., Sghaier H., Narumi I., Yamaguchi S., Umeda K., Inagaki K.
      J. Biosci. Bioeng. 101:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, COFACTOR, SUBUNIT, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
      Strain: KR1.

    Entry informationi

    Entry nameiCATA_DEIRA
    AccessioniPrimary (citable) accession number: Q59337
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3