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Q59335 (HEM4_CHLP8) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III synthase

Short name=UROS
EC=4.2.1.75
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene names
Name:hemD
Ordered Locus Names:Cpar_0736
OrganismChlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327)) [Complete proteome] [HAMAP]
Taxonomic identifier517417 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activity

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.

Sequence similarities

Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionuroporphyrinogen-III synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Uroporphyrinogen-III synthase
PRO_0000135242

Sequences

Sequence LengthMass (Da)Tools
Q59335 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 58DA229096BCCE1C

FASTA24626,786
        10         20         30         40         50         60 
MKTVLVTRPK HQAAPFVREL EQYGLSTVVF PTIEIRPVAG WNVPDLTKFA GIFFTSPNSV 

        70         80         90        100        110        120 
QFFLKHLLQT APDELKNLQQ TRVWAVGKTT GQDLEKHGVS IEPLPKIADA VNLMADIDPA 

       130        140        150        160        170        180 
EIKGQTFLFV RGSLSLGTIP ELIAEFGGTC VELTVYENLP PSLEDTQRVK DMLAEGKLDC 

       190        200        210        220        230        240 
LSFTSPSTAK NFFEAIGSKE LSDSVQIAAI GTTTSGALEK MGIKVDIIPE YFDGPSFAKA 


IAEALK 

« Hide

References

« Hide 'large scale' references
[1]Majumdar D., Wyche J.H.
Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of Chlorobaculum parvum NCIB 8327."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Zhao F., Li T., Liu Z. expand/collapse author list , Overmann J., Bryant D.A., Richardson P.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCIB 8327.
[3]"Structure and expression of the Chlorobium vibrioforme hemB gene and characterization of its encoded enzyme, porphobilinogen synthase."
Rhie G.-E., Avissar Y.J., Beale S.I.
J. Biol. Chem. 271:8176-8182(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 187-246.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M96364 Genomic DNA. Translation: AAA23114.1.
CP001099 Genomic DNA. Translation: ACF11153.1.
U38348 Genomic DNA. Translation: AAC43974.1.
RefSeqYP_001998353.1. NC_011027.1.

3D structure databases

ProteinModelPortalQ59335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING517417.Cpar_0736.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACF11153; ACF11153; Cpar_0736.
GeneID6419663.
KEGGcpc:Cpar_0736.
PATRIC21364730. VBIChlPar72705_0735.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1587.
HOGENOMHOG000152969.
KOK01719.
OMAVDIIPEY.
OrthoDBEOG6JQH1B.
ProtClustDBCLSK637759.

Enzyme and pathway databases

BioCycCPAR517417:GH95-764-MONOMER.
UniPathwayUPA00251; UER00320.

Family and domain databases

InterProIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMSSF69618. SSF69618. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEM4_CHLP8
AccessionPrimary (citable) accession number: Q59335
Secondary accession number(s): B3QMK0, Q59333
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 13, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways