Q59335 (HEM4_CHLP8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen-III synthase
Short name=UROS
EC=4.2.1.75

Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase

Gene names

Name:	hemD
Ordered Locus Names:	Cpar_0736

Organism

Chlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327)) [Complete proteome] [HAMAP]

Taxonomic identifier

517417 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum › Chlorobaculum parvum

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.
Catalytic activity	Hydroxymethylbilane = uroporphyrinogen III + H2O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
Sequence similarities	Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	uroporphyrinogen-III synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Uroporphyrinogen-III synthase		PRO_0000135242

Sequences

	Sequence		Length	Mass (Da)
	Q59335 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 58DA229096BCCE1C	FASTA	246	26,786
	10 20 30 40 50 60 MKTVLVTRPK HQAAPFVREL EQYGLSTVVF PTIEIRPVAG WNVPDLTKFA GIFFTSPNSV 70 80 90 100 110 120 QFFLKHLLQT APDELKNLQQ TRVWAVGKTT GQDLEKHGVS IEPLPKIADA VNLMADIDPA 130 140 150 160 170 180 EIKGQTFLFV RGSLSLGTIP ELIAEFGGTC VELTVYENLP PSLEDTQRVK DMLAEGKLDC 190 200 210 220 230 240 LSFTSPSTAK NFFEAIGSKE LSDSVQIAAI GTTTSGALEK MGIKVDIIPE YFDGPSFAKA IAEALK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Majumdar D., Wyche J.H. Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of Chlorobaculum parvum NCIB 8327." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Zhao F., Li T., Liu Z. , Overmann J., Bryant D.A., Richardson P. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCIB 8327.
[3]	"Structure and expression of the Chlorobium vibrioforme hemB gene and characterization of its encoded enzyme, porphobilinogen synthase." Rhie G.-E., Avissar Y.J., Beale S.I. J. Biol. Chem. 271:8176-8182(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 187-246.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M96364 Genomic DNA. Translation: AAA23114.1. CP001099 Genomic DNA. Translation: ACF11153.1. U38348 Genomic DNA. Translation: AAC43974.1.
RefSeq	YP_001998353.1. NC_011027.1.
3D structure databases
ProteinModelPortal	Q59335.
ModBase	Search...
Protein-protein interaction databases
STRING	517417.Cpar_0736.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACF11153; ACF11153; Cpar_0736.
GeneID	6419663.
KEGG	cpc:Cpar_0736.
PATRIC	21364730. VBIChlPar72705_0735.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1587.
HOGENOM	HOG000152969.
KO	K01719.
OMA	VDIIPEY.
ProtClustDB	CLSK637759.
Enzyme and pathway databases
BioCyc	CPAR517417:GH95-764-MONOMER.
UniPathway	UPA00251; UER00320.
Family and domain databases
InterPro	IPR003754. 4pyrrol_synth_uPrphyn_synth. [Graphical view]
Pfam	PF02602. HEM4. 1 hit. [Graphical view]
SUPFAM	SSF69618. HEM4_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HEM4_CHLP8

Accession

Primary (citable) accession number: Q59335
Secondary accession number(s): B3QMK0, Q59333

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program