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Q59335

- HEM4_CHLP8

UniProt

Q59335 - HEM4_CHLP8

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Protein

Uroporphyrinogen-III synthase

Gene

hemD

Organism
Chlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciCPAR517417:GH95-764-MONOMER.
UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:Cpar_0736
OrganismiChlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))
Taxonomic identifieri517417 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
ProteomesiUP000008811: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Uroporphyrinogen-III synthasePRO_0000135242Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi517417.Cpar_0736.

Structurei

3D structure databases

ProteinModelPortaliQ59335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000152969.
KOiK01719.
OMAiDCLSFTS.
OrthoDBiEOG6JQH1B.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59335-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTVLVTRPK HQAAPFVREL EQYGLSTVVF PTIEIRPVAG WNVPDLTKFA
60 70 80 90 100
GIFFTSPNSV QFFLKHLLQT APDELKNLQQ TRVWAVGKTT GQDLEKHGVS
110 120 130 140 150
IEPLPKIADA VNLMADIDPA EIKGQTFLFV RGSLSLGTIP ELIAEFGGTC
160 170 180 190 200
VELTVYENLP PSLEDTQRVK DMLAEGKLDC LSFTSPSTAK NFFEAIGSKE
210 220 230 240
LSDSVQIAAI GTTTSGALEK MGIKVDIIPE YFDGPSFAKA IAEALK
Length:246
Mass (Da):26,786
Last modified:November 1, 1996 - v1
Checksum:i58DA229096BCCE1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96364 Genomic DNA. Translation: AAA23114.1.
CP001099 Genomic DNA. Translation: ACF11153.1.
U38348 Genomic DNA. Translation: AAC43974.1.
RefSeqiYP_001998353.1. NC_011027.1.

Genome annotation databases

EnsemblBacteriaiACF11153; ACF11153; Cpar_0736.
GeneIDi6419663.
KEGGicpc:Cpar_0736.
PATRICi21364730. VBIChlPar72705_0735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96364 Genomic DNA. Translation: AAA23114.1 .
CP001099 Genomic DNA. Translation: ACF11153.1 .
U38348 Genomic DNA. Translation: AAC43974.1 .
RefSeqi YP_001998353.1. NC_011027.1.

3D structure databases

ProteinModelPortali Q59335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 517417.Cpar_0736.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF11153 ; ACF11153 ; Cpar_0736 .
GeneIDi 6419663.
KEGGi cpc:Cpar_0736.
PATRICi 21364730. VBIChlPar72705_0735.

Phylogenomic databases

eggNOGi COG1587.
HOGENOMi HOG000152969.
KOi K01719.
OMAi DCLSFTS.
OrthoDBi EOG6JQH1B.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .
BioCyci CPAR517417:GH95-764-MONOMER.

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Majumdar D., Wyche J.H.
    Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCIB 8327.
  3. "Structure and expression of the Chlorobium vibrioforme hemB gene and characterization of its encoded enzyme, porphobilinogen synthase."
    Rhie G.-E., Avissar Y.J., Beale S.I.
    J. Biol. Chem. 271:8176-8182(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 187-246.

Entry informationi

Entry nameiHEM4_CHLP8
AccessioniPrimary (citable) accession number: Q59335
Secondary accession number(s): B3QMK0, Q59333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3