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Protein

Uroporphyrinogen-III synthase

Gene

hemD

Organism
Chlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase (hemB)
  2. Porphobilinogen deaminase (hemC)
  3. Uroporphyrinogen-III synthase (hemD)
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:Cpar_0736
OrganismiChlorobaculum parvum (strain NCIB 8327) (Chlorobium vibrioforme subsp. thiosulfatophilum (strain DSM 263 / NCIB 8327))
Taxonomic identifieri517417 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000008811 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352421 – 246Uroporphyrinogen-III synthaseAdd BLAST246

Interactioni

Protein-protein interaction databases

STRINGi517417.Cpar_0736.

Structurei

3D structure databases

ProteinModelPortaliQ59335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107ZGR. Bacteria.
COG1587. LUCA.
HOGENOMiHOG000152969.
KOiK01719.
OMAiVWAVGKT.
OrthoDBiPOG091H09IX.

Family and domain databases

CDDicd06578. HemD. 1 hit.
InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTVLVTRPK HQAAPFVREL EQYGLSTVVF PTIEIRPVAG WNVPDLTKFA
60 70 80 90 100
GIFFTSPNSV QFFLKHLLQT APDELKNLQQ TRVWAVGKTT GQDLEKHGVS
110 120 130 140 150
IEPLPKIADA VNLMADIDPA EIKGQTFLFV RGSLSLGTIP ELIAEFGGTC
160 170 180 190 200
VELTVYENLP PSLEDTQRVK DMLAEGKLDC LSFTSPSTAK NFFEAIGSKE
210 220 230 240
LSDSVQIAAI GTTTSGALEK MGIKVDIIPE YFDGPSFAKA IAEALK
Length:246
Mass (Da):26,786
Last modified:November 1, 1996 - v1
Checksum:i58DA229096BCCE1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96364 Genomic DNA. Translation: AAA23114.1.
CP001099 Genomic DNA. Translation: ACF11153.1.
U38348 Genomic DNA. Translation: AAC43974.1.
RefSeqiWP_012501986.1. NC_011027.1.

Genome annotation databases

EnsemblBacteriaiACF11153; ACF11153; Cpar_0736.
KEGGicpc:Cpar_0736.
PATRICi21364730. VBIChlPar72705_0735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96364 Genomic DNA. Translation: AAA23114.1.
CP001099 Genomic DNA. Translation: ACF11153.1.
U38348 Genomic DNA. Translation: AAC43974.1.
RefSeqiWP_012501986.1. NC_011027.1.

3D structure databases

ProteinModelPortaliQ59335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi517417.Cpar_0736.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF11153; ACF11153; Cpar_0736.
KEGGicpc:Cpar_0736.
PATRICi21364730. VBIChlPar72705_0735.

Phylogenomic databases

eggNOGiENOG4107ZGR. Bacteria.
COG1587. LUCA.
HOGENOMiHOG000152969.
KOiK01719.
OMAiVWAVGKT.
OrthoDBiPOG091H09IX.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.

Family and domain databases

CDDicd06578. HemD. 1 hit.
InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHEM4_CHLP8
AccessioniPrimary (citable) accession number: Q59335
Secondary accession number(s): B3QMK0, Q59333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.