Reviewed, UniProtKB/Swiss-Prot Q59332 (PLD_CORUL)

Names and origin

Protein names

Recommended name:
    Phospholipase D
    EC=3.1.4.4
Alternative name(s):
    Choline phosphatase

Gene names

Name:

pld

Organism

Corynebacterium ulcerans

Taxonomic identifier

65058 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has sphingomyelinase and hemolytic activity. Thought to act as a virulence factor.
Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate.

Ontologies

Keywords
Biological process	Lipid degradation Virulence
Domain	Signal
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	By similarity
	Chain	25 – 307	283	Phospholipase D		PRO_0000022067
Sites
	Active site	44	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59332-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A315E3B2827A8732	FASTA	307	33,681
	10 20 30 40 50 60 MKKKVVLFLS IIMGILFPVG NAVATPVSHD AASTGNRPVY AIAHRVLTTQ GVDDAVAIGA 70 80 90 100 110 120 NALEIDFTAW RGGWWADHDG IPTSAGATAE AIFKHIAEKR NQGANITFTW LDIKNPDYCT 130 140 150 160 170 180 DPHSVCSINA LRDLARKYLE PAGVRVLYGF YKTVGGPGWK TITSDLRDNE AVALSGPTRD 190 200 210 220 230 240 VLNDFAKAGD KILTKQKIAD YGYYDINQGF GDCYGDGNKT CDQLRKSSEA RDQGKLGKTF 250 260 270 280 290 300 GWTITTGQDD RVNDLLGKAH VDGMIFGFKV THFYRHADTE NSFKAIKTWV DKHSDTHHLA TAADNPW

References

[1]	"Toxic phospholipases D of Corynebacterium pseudotuberculosis, C. ulcerans and Arcanobacterium haemolyticum: cloning and sequence homology." McNamara P.J., Cuevas W.A., Songer J.G. Gene 156:113-118(1995) [PubMed: 7737503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 739.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L16585 Genomic DNA. Translation: AAB68401.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.1.4.4. 20485.
Family and domain databases
InterPro	IPR016674. PLipase_D_bac/fun. [Graphical view]
PIRSF	PIRSF016632. Phospholipase_actinobac/fun. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLD_CORUL

Accession

Primary (citable) accession number: Q59332

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)