Q59331 (ACKA_THETC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	Tthe_1501

Organism

Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIB 9385 / NCA 3814) (Clostridium thermosaccharolyticum) [Complete proteome] [HAMAP]

Taxonomic identifier

580327 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Thermoanaerobacterium

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the activation of acetate to acetyl CoA and the secretion of acetate By similarity. HAMAP MF_00020
Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Acetate kinase HAMAP MF_00020		PRO_0000107550
Experimental info
	Sequence conflict	134	1	K → T in CAA95986. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q59331 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: D218E24024491577	FASTA	400	43,847
	10 20 30 40 50 60 MKILVINCGS SSLKYQLIES KDGNVLAKGL AERIGINDSL LTHNANGEKI KIKKDMKDHK 70 80 90 100 110 120 DAIKLVLDAL VNSDYGVIKD MSEIDAVGHR VVHGGEYFTS SVLITDDVLK AITDCIELAP 130 140 150 160 170 180 LHNPANIEGI KACKQIMPDV PMVAVFDTAF HQTMPDYAYL YPIPYEYYTK YKIRKYGFHG 190 200 210 220 230 240 TSHKYVSQRA AEILNKPIES LKIITCHLGN GSSIAAVKNG KSIDTSMGFT PLEGLAMGTR 250 260 270 280 290 300 SGSIDPSIIS YLMEKENISA EEVVNILNKK SGVYGISGIS SDFRDLEDAA FKNGDKRAQL 310 320 330 340 350 360 ALNVFAYRVK KTIGSYAAAM GGVDVIVFTA GIGENGPEIR EFILDGLEFL GFKLDKEKNK 370 380 390 400 VRGEEAIIST ADSKVNVMVV PTNEEYMIAK DTEKIVESLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Joerges A., Bronnenmeier K., Lottspeich F., Staudenbauer W.L. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 7956 / DSM 571 / NCIB 9385 / NCA 3814.
[2]	van Rinsum A. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 7956 / DSM 571 / NCIB 9385 / NCA 3814.
[3]	"Complete sequence of Thermoanaerobacterium thermosaccharolyticum DSM 571." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N., Hemme C.L., Woyke T. Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 7956 / DSM 571 / NCIB 9385 / NCA 3814.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z71384 Genomic DNA. Translation: CAA95986.1. AJ004870 Genomic DNA. Translation: CAA06175.1. CP002171 Genomic DNA. Translation: ADL69011.1.
RefSeq	YP_003852095.1. NC_014410.1.
3D structure databases
ProteinModelPortal	Q59331.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9707057.
GenomeReviews	Gene locus Tthe_1501 in contig CP002171_GR.
KEGG	ttm:Tthe_1501.
PATRIC	42452349. VBITheThe89703_1521.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_THETC

Accession

Primary (citable) accession number: Q59331
Secondary accession number(s): D9TNN6, O65981

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 30, 2010
Last modified:	January 25, 2012
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program