Reviewed, UniProtKB/Swiss-Prot Q59331 (ACKA_CLOTS)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:

ackA

Organism

Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum)

Taxonomic identifier

1517 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Thermoanaerobacterium

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the activation of acetate to acetyl CoA and the secretion of acetate By similarity.
Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm. HAMAP MF_00020
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Acetate kinase HAMAP MF_00020		PRO_0000107550
Experimental info
	Sequence conflict	134	1	T → K in CAA06175. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q59331-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7D18E412CB491BB8	FASTA	400	43,820
	10 20 30 40 50 60 MKILVINCGS SSLKYQLIES KDGNVLAKGL AERIGINDSL LTHNANGEKI KIKKDMKDHK 70 80 90 100 110 120 DAIKLVLDAL VNSDYGVIKD MSEIDAVGHR VVHGGEYFTS SVLITDDVLK AITDCIELAP 130 140 150 160 170 180 LHNPANIEGI KACTQIMPDV PMVAVFDTAF HQTMPDYAYL YPIPYEYYTK YKIRKYGFHG 190 200 210 220 230 240 TSHKYVSQRA AEILNKPIES LKIITCHLGN GSSIAAVKNG KSIDTSMGFT PLEGLAMGTR 250 260 270 280 290 300 SGSIDPSIIS YLMEKENISA EEVVNILNKK SGVYGISGIS SDFRDLEDAA FKNGDKRAQL 310 320 330 340 350 360 ALNVFAYRVK KTIGSYAAAM GGVDVIVFTA GIGENGPEIR EFILDGLEFL GFKLDKEKNK 370 380 390 400 VRGEEAIIST ADSKVNVMVV PTNEEYMIAK DTEKIVESLK

References

[1]	Joerges A., Bronnenmeier K., Lottspeich F., Staudenbauer W.L. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 7956 / DSM 571 / LMG 2811 / NCA 3814 / NCIB 9385.
[2]	van Rinsum A. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 7956 / DSM 571 / LMG 2811 / NCA 3814 / NCIB 9385.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z71384 Genomic DNA. Translation: CAA95986.1. AJ004870 Genomic DNA. Translation: CAA06175.1.
3D structure databases
HSSP	HSSP built from PDB template 1G99 based on UniProtKB P38502.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.2.1. 486.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate_kin. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_CLOTS

Accession

Primary (citable) accession number: Q59331
Secondary accession number(s): O65981

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)