Reviewed, UniProtKB/Swiss-Prot Q59330 (PTA_CLOTS)

Names and origin

Protein names

Recommended name:
    Phosphate acetyltransferase
    EC=2.3.1.8
Alternative name(s):
    Phosphotransacetylase

Gene names

Name:	pta
Synonyms:	ptaA

Organism

Clostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum)

Taxonomic identifier

1517 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Thermoanaerobacterium

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + phosphate = CoA + acetyl phosphate.
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the phosphate acetyltransferase and butyryltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphate acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Phosphate acetyltransferase		PRO_0000179127
Experimental info
	Sequence conflict	31 – 32	2	AA → GP in CAA06174. Ref.2
	Sequence conflict	91	1	L → I in CAA06174. Ref.2
	Sequence conflict	113 – 117	5	RRLCS → EGYAD in CAA06174. Ref.2
	Sequence conflict	125	1	D → H in CAA06174. Ref.2
	Sequence conflict	137	1	N → I in CAA06174. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q59330-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D23F4A0629DA73DE	FASTA	328	35,035
	10 20 30 40 50 60 MSIIQSIIEK AKSNKKKIVL PEGAEPRTLK AADIVLKEGI ADLVLLGNAD EIRNAAEGLD 70 80 90 100 110 120 ISKAEIIDPL KSEKFDKYAT DFYELRKNKG LTLEKAKETI KDNIYFGCMM VKRRLCSGLV 130 140 150 160 170 180 SGAIDATADL LRPAFQNVKT APGAKIVSSF FIMEVPNCEF GENGVFLFAD CAVNPSPNAE 190 200 210 220 230 240 ELASIAVQSA NTAKTLLGME PRVAMLSFST KGSASHELVD KVRTATEIAK NLIPDVAIDG 250 260 270 280 290 300 ELQLDADVVK EVAELKAPGS PVAGRANVLI FPDLQAGNIG YKLVQRLAKA NAIGPITQGM 310 320 GAPVNDLSRG CSYKDIVDVI ATTAVQAQ

References

[1]	Joerges A., Bronnenmeier K., Lottspeich F., Staudenbauer W.L. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 7956 / DSM 571 / LMG 2811 / NCA 3814 / NCIB 9385.
[2]	van Rinsum A. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 7956 / DSM 571 / LMG 2811 / NCA 3814 / NCIB 9385.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z71384 Genomic DNA. Translation: CAA95985.1. AJ004870 Genomic DNA. Translation: CAA06174.1.
3D structure databases
SMR	Q59330. Positions 1-328.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.3.1.8. 486.
Family and domain databases
InterPro	IPR012147. P_Ac_Bu_trans. IPR004614. P_AcTrfase. IPR002505. PTA_PTB. [Graphical view]
Pfam	PF01515. PTA_PTB. 1 hit. [Graphical view]
PIRSF	PIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMs	TIGR00651. pta. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTA_CLOTS

Accession

Primary (citable) accession number: Q59330
Secondary accession number(s): O65980

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)