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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIB 9385 / NCA 3814) (Clostridium thermosaccharolyticum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciTTHE580327:G1GMN-1517-MONOMER
UniPathwayiUPA00340; UER00459

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Synonyms:ptaA
Ordered Locus Names:Tthe_1502
OrganismiThermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIB 9385 / NCA 3814) (Clostridium thermosaccharolyticum)
Taxonomic identifieri580327 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisThermoanaerobacterium
Proteomesi
  • UP000001626 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791271 – 328Phosphate acetyltransferaseAdd BLAST328

Proteomic databases

PRIDEiQ59330

Interactioni

Protein-protein interaction databases

STRINGi580327.Tthe_1502

Structurei

3D structure databases

SMRiQ59330
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IJ2 Bacteria
COG0280 LUCA
HOGENOMiHOG000053796
KOiK00625
OMAiTMLVKMG
OrthoDBiPOG091H01MW

Family and domain databases

InterProiView protein in InterPro
IPR012147 P_Ac_Bu_trans
IPR004614 P_AcTrfase
IPR002505 PTA_PTB
PfamiView protein in Pfam
PF01515 PTA_PTB, 1 hit
PIRSFiPIRSF000428 P_Ac_trans, 1 hit
TIGRFAMsiTIGR00651 pta, 1 hit

Sequencei

Sequence statusi: Complete.

Q59330-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIIQSIIEK AKSNKKKIVL PEGAEPRTLK AADIVLKEGI ADLVLLGNAD
60 70 80 90 100
EIRNAAEGLD ISKAEIIDPL KSEKFDKYAT DFYELRKNKG ITLEKAKETI
110 120 130 140 150
KDNIYFGCMM VKEGYADGLV SGAIHATADL LRPAFQIVKT APGAKIVSSF
160 170 180 190 200
FIMEVPNCEF GENGVFLFAD CAVNPSPNAE ELASIAVQSA NTAKTLLGME
210 220 230 240 250
PRVAMLSFST KGSASHELVD KVRTATEIAK NLIPDVAIDG ELQLDAALVK
260 270 280 290 300
EVAELKAPGS PVAGRANVLI FPDLQAGNIG YKLVQRLAKA NAIGPITQGM
310 320
GAPVNDLSRG CSYKDIVDVI ATTAVQAQ
Length:328
Mass (Da):34,945
Last modified:November 30, 2010 - v2
Checksum:i11C4C57B4DA39D17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31 – 32AA → GP in CAA06174 (Ref. 2) Curated2
Sequence conflicti91I → L in CAA95985 (Ref. 1) Curated1
Sequence conflicti113 – 117EGYAD → RRLCS in CAA95985 (Ref. 1) Curated5
Sequence conflicti125H → D in CAA95985 (Ref. 1) Curated1
Sequence conflicti137I → N in CAA95985 (Ref. 1) Curated1
Sequence conflicti247 – 248AL → DV in CAA95985 (Ref. 1) Curated2
Sequence conflicti247 – 248AL → DV in CAA06174 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71384 Genomic DNA Translation: CAA95985.1
AJ004870 Genomic DNA Translation: CAA06174.1
CP002171 Genomic DNA Translation: ADL69012.1
RefSeqiWP_013297979.1, NC_014410.1

Genome annotation databases

EnsemblBacteriaiADL69012; ADL69012; Tthe_1502
KEGGittm:Tthe_1502

Similar proteinsi

Entry informationi

Entry nameiPTAS_THETC
AccessioniPrimary (citable) accession number: Q59330
Secondary accession number(s): D9TNN7, O65980
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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