ID   Q59323_THETR            Unreviewed;       498 AA.
AC   Q59323; O08504; O08515;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   08-NOV-2023, entry version 78.
DE   SubName: Full=Butyryl-CoA: acetate coenzyem A transferase {ECO:0000313|EMBL:CAB04794.1};
DE            EC=2.8.3.8 {ECO:0000313|EMBL:CAA93155.1, ECO:0000313|EMBL:CAB04794.1};
DE   SubName: Full=Butyryl-CoA:Acetate Coenzyme A transferase {ECO:0000313|EMBL:CAA93155.1};
DE   SubName: Full=Butyryl-CoA:acetate CoA transferase {ECO:0000313|EMBL:CAB07501.1};
GN   Name=actA {ECO:0000313|EMBL:CAA93155.1};
OS   Thermoanaerobacterium thermosaccharolyticum (Clostridium
OS   thermosaccharolyticum).
OC   Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Thermoanaerobacterium.
OX   NCBI_TaxID=1517 {ECO:0000313|EMBL:CAA93155.1};
RN   [1] {ECO:0000313|EMBL:CAA93155.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 571 {ECO:0000313|EMBL:CAA93155.1};
RA   Joerges A., Bronnenmeier K., Lottspeich F., Staudenbauer W.L.;
RL   Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAB04794.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 571 {ECO:0000313|EMBL:CAB04794.1};
RA   Van Rinsum A., Bronnenmeier K., Staudenbauer W.;
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CAB07501.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 571 {ECO:0000313|EMBL:CAB07501.1};
RA   Van Rinsum A., Bronnenmeier K., Staudenbauer W.L.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family.
CC       {ECO:0000256|ARBA:ARBA00009632}.
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DR   EMBL; Z69031; CAA93155.1; -; Genomic_DNA.
DR   EMBL; Z82038; CAB04794.1; -; Genomic_DNA.
DR   EMBL; Z92974; CAB07501.1; -; Genomic_DNA.
DR   PIR; T45465; T45465.
DR   AlphaFoldDB; Q59323; -.
DR   GO; GO:0008775; F:acetate CoA-transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006083; P:acetate metabolic process; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.750.70; 4-hydroxybutyrate coenzyme like domains; 1.
DR   Gene3D; 3.40.1080.20; Acetyl-CoA hydrolase/transferase C-terminal domain; 1.
DR   Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR   InterPro; IPR026888; AcetylCoA_hyd_C.
DR   InterPro; IPR038460; AcetylCoA_hyd_C_sf.
DR   InterPro; IPR046433; ActCoA_hydro.
DR   InterPro; IPR003702; ActCoA_hydro_N.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR017821; Succinate_CoA_transferase.
DR   NCBIfam; TIGR03458; YgfH_subfam; 1.
DR   PANTHER; PTHR43609; ACETYL-COA HYDROLASE; 1.
DR   PANTHER; PTHR43609:SF1; ACETYL-COA HYDROLASE; 1.
DR   Pfam; PF13336; AcetylCoA_hyd_C; 1.
DR   Pfam; PF02550; AcetylCoA_hydro; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE   3: Inferred from homology;
KW   Transferase {ECO:0000313|EMBL:CAA93155.1}.
FT   DOMAIN          14..215
FT                   /note="Acetyl-CoA hydrolase/transferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02550"
FT   DOMAIN          317..463
FT                   /note="Acetyl-CoA hydrolase/transferase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13336"
FT   ACT_SITE        288
FT                   /note="5-glutamyl coenzyme A thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-1"
FT   BINDING         263..267
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         358
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         378
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         382
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
FT   BINDING         402
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR617821-2"
SQ   SEQUENCE   498 AA;  55204 MW;  7A8A5E3DB7CAD7BD CRC64;
     MNFEERIRCN IIKNKVMSAE EAALLIKDGM TIGTSGFVTG GPKAVPLAIA ERYKNEKIKL
     NLYTGAIVGD ELDGAFAREG LVNKRIPYQT NKDMRNAINN GSVKFIDMHL SHMPQQIRYG
     FLGKIDIAII EATAITEDGG IIPTMSVGNS PTFVNMADKV IVEINTSQPI ELEGMHDIYE
     PKDPPYREPI PISKVSDRIG VPYIPCNPDK IAAVVFSDMK DTTLQLTSIN ETSKKISDYL
     IDFLQTEIKH GRLPKTFLPL QSGIGNVANA VLGGFIELKY NNLNLYSEVI QDAVLDLIDA
     DKVEKVSGTA LTLSEEGLKR FYTNINKYKD KIILRPQELS NNPEIIRRLG VISINTAIEV
     DIYGNVNSTH ILGTKMMNGI GGSADFTRNA YISIFATPST AKDDNISCIV PMVSHVDHTE
     HDVMVVVTEQ GLADLRGLSP KERAIAIIKN CAHPDYKDVL MEYYERAIKK HGAVQTPNLL
     DEAFLWHTRY SNTGSMKI
//