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Protein

60 kDa chaperonin

Gene

groL

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Heat shock protein 60
Short name:
HSP60
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:TC_0386
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000800 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000633272 – 54460 kDa chaperoninAdd BLAST543

Proteomic databases

PRIDEiQ59322.

Expressioni

Inductioni

By stress.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi243161.CmurN_010100001933.

Structurei

3D structure databases

ProteinModelPortaliQ59322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
KOiK04077.
OMAiMLTTDCA.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAKNIKYNE EARKKIQKGV KTLAEAVKVT LGPKGRHVVI DKSFGSPQVT
60 70 80 90 100
KDGVTVAKEV ELADKHENMG AQMVKEVASK TADKAGDGTT TATVLAEAIY
110 120 130 140 150
TEGLRNVTAG ANPMDLKRGI DKAVKVVVDQ IKKISKPVQH HKEIAQVATI
160 170 180 190 200
SANNDAEIGN LIAEAMEKVG KNGSITVEEA KGFETVLDVV EGMNFNRGYL
210 220 230 240 250
SSYFATNPET QECVLEDALV LIYDKKISGI KDFLPVLQQV AESGRPLLII
260 270 280 290 300
AEDIEGEALA TLVVNRIRGG FRVCAVKAPG FGDRRKAMLE DIAILTGGQL
310 320 330 340 350
ISEELGMKLE NASLAMLGKA KKVIVSKEDT TIVEGMGEKE ALDARCESIK
360 370 380 390 400
KQIEDSTSDY DKEKLQERLA KLSGGVAVIR VGAATEIEMK EKKDRVDDAQ
410 420 430 440 450
HATIAAVEEG ILPGGGTALI RCIPTLEAFL PMLTNEDERI GARIVLKALS
460 470 480 490 500
APLKQIAANA GKEGAIIFQQ VMSRSANEGY DALRDAYTDM IEAGILDPAK
510 520 530 540
VTRSALESAA SVAGLLLTTE ALIAEIPEEK PAAAPAMPGA GMDY
Length:544
Mass (Da):58,106
Last modified:January 23, 2007 - v3
Checksum:i3C7660523E0B2701
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti387I → N in AAA19871 (PubMed:7909303).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12004 Genomic DNA. Translation: AAA19871.1.
U52049 Genomic DNA. Translation: AAA97911.1.
AE002160 Genomic DNA. Translation: AAF39243.1.
PIRiD81709.
I40731.
RefSeqiWP_010230304.1. NZ_ACOV01000003.1.

Genome annotation databases

EnsemblBacteriaiAAF39243; AAF39243; TC_0386.
GeneIDi1245738.
KEGGicmu:TC_0386.
PATRICi20372172. VBIChlMur19118_0410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12004 Genomic DNA. Translation: AAA19871.1.
U52049 Genomic DNA. Translation: AAA97911.1.
AE002160 Genomic DNA. Translation: AAF39243.1.
PIRiD81709.
I40731.
RefSeqiWP_010230304.1. NZ_ACOV01000003.1.

3D structure databases

ProteinModelPortaliQ59322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243161.CmurN_010100001933.

Proteomic databases

PRIDEiQ59322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF39243; AAF39243; TC_0386.
GeneIDi1245738.
KEGGicmu:TC_0386.
PATRICi20372172. VBIChlMur19118_0410.

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
KOiK04077.
OMAiMLTTDCA.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH60_CHLMU
AccessioniPrimary (citable) accession number: Q59322
Secondary accession number(s): P56837
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.