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Q59310

- Q59310_CLOPF

UniProt

Q59310 - Q59310_CLOPF

Protein
Submitted name:

Exo-alpha-sialidase

Gene

nanH

Organism
Clostridium perfringens
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi296 – 2961CalciumImported
    Metal bindingi298 – 2981CalciumImported
    Metal bindingi319 – 3191CalciumImported
    Metal bindingi320 – 3201Calcium; via carbonyl oxygenImported

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseImported, Hydrolase

    Keywords - Ligandi

    CalciumImported, Metal-bindingImported

    Protein family/group databases

    CAZyiCBM40. Carbohydrate-Binding Module Family 40.
    GH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Exo-alpha-sialidaseImported (EC:3.2.1.18Imported)
    Gene namesi
    Name:nanHImported
    OrganismiClostridium perfringensImported
    Taxonomic identifieri1502 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4141 PotentialImportedAdd
    BLAST
    Chaini42 – 694653 PotentialImportedPRO_5000146477Add
    BLAST

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BF6X-ray0.97A243-691[»]
    2VK5X-ray0.97A243-694[»]
    2VK6X-ray1.50A243-694[»]
    2VK7X-ray1.20A/B243-694[»]
    ProteinModelPortaliQ59310.
    SMRiQ59310. Positions 42-236, 243-690.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ59310.

    Family & Domainsi

    Keywords - Domaini

    SignalImported

    Family and domain databases

    Gene3Di2.120.10.10. 2 hits.
    2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR004124. Glyco_hydro_33_N.
    IPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PfamiPF02973. Sialidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q59310-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYKGITLIL TAAMVISGGN YVLVKGSTLD SGKNNSGYEI KVNNSENLSS    50
    LGEYKDINLE SSNASNITYD LEKYKNLDEG TIVVRFNSKD SKIQSLLGIS 100
    NSKTKNGYFN FYVTNSRVGF ELRNQKNEGN TQSGTENLVH MYKDVALNDG 150
    DNTVALKIEK NKGYKLFLNG KIIKEVKDTN TKFLNNIENL DSAFIGKTNR 200
    YGQSNEYNFK GNIGFMNIYN EPLGDDYLLS KTGETKAKEE VLVEGAVKTE 250
    PVDLFHPGFL NSSNYRIPAL FKTKEGTLIA SIDARRHGGA DAPNNDIDTA 300
    VRRSEDGGKT WDEGQIIMDY PDKSSVIDTT LIQDDETGRI FLLVTHFPSK 350
    YGFWNAGLGS GFKNIDGKEY LCLYDSSGKE FTVRENVVYD KDGNKTEYTT 400
    NALGDLFKNG TKIDNINSST APLKAKGTSY INLVYSDDDG KTWSEPQNIN 450
    FQVKKDWMKF LGIAPGRGIQ IKNGEHKGRI VVPVYYTNEK GKQSSAVIYS 500
    DDSGKNWTIG ESPNDNRKLE NGKIINSKTL SDDAPQLTEC QVVEMPNGQL 550
    KLFMRNLSGY LNIATSFDGG ATWDETVEKD TNVLEPYCQL SVINYSQKVD 600
    GKDAVIFSNP NARSRSNGTV RIGLINQVGT YENGEPKYEF DWKYNKLVKP 650
    GYYAYSCLTE LSNGNIGLLY EGTPSEEMSY IEMNLKYLES GANK 694
    Length:694
    Mass (Da):77,327
    Last modified:November 1, 1996 - v1
    Checksum:i22D23E25A0A8DC72
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87369 Genomic DNA. Translation: CAA60796.1.
    PIRiI40866.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87369 Genomic DNA. Translation: CAA60796.1 .
    PIRi I40866.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BF6 X-ray 0.97 A 243-691 [» ]
    2VK5 X-ray 0.97 A 243-694 [» ]
    2VK6 X-ray 1.50 A 243-694 [» ]
    2VK7 X-ray 1.20 A/B 243-694 [» ]
    ProteinModelPortali Q59310.
    SMRi Q59310. Positions 42-236, 243-690.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi CBM40. Carbohydrate-Binding Module Family 40.
    GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q59310.

    Family and domain databases

    Gene3Di 2.120.10.10. 2 hits.
    2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR004124. Glyco_hydro_33_N.
    IPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    Pfami PF02973. Sialidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Gene structure of the 'large' sialidase isoenzyme from Clostridium perfringens A99 and its relationship with other clostridial nanH proteins."
      Traving C., Schauer R., Roggentin P.
      Glycoconj. J. 11:141-151(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A99Imported.
    2. Schauer R.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A99Imported.
    3. "The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates."
      Newstead S.L., Potter J.A., Wilson J.C., Xu G., Chien C.H., Watts A.G., Withers S.G., Taylor G.L.
      J. Biol. Chem. 283:9080-9088(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (0.97 ANGSTROMS) OF 243-691 IN COMPLEX WITH CALCIUM.

    Entry informationi

    Entry nameiQ59310_CLOPF
    AccessioniPrimary (citable) accession number: Q59310
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3