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Protein
Submitted name:

Exo-alpha-sialidase

Gene

nanH

Organism
Clostridium perfringens
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi296CalciumCombined sources1
Metal bindingi298CalciumCombined sources1
Metal bindingi319CalciumCombined sources1
Metal bindingi320Calcium; via carbonyl oxygenCombined sources1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseImported, Hydrolase

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BRENDAi3.2.1.18. 1503.

Protein family/group databases

CAZyiCBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Exo-alpha-sialidaseImported (EC:3.2.1.18Imported)
Gene namesi
Name:nanHImported
OrganismiClostridium perfringensImported
Taxonomic identifieri1502 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Interactioni

Protein-protein interaction databases

STRINGi195103.CPF_0721.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BF6X-ray0.97A243-691[»]
2VK5X-ray0.97A243-694[»]
2VK6X-ray1.50A243-694[»]
2VK7X-ray1.20A/B243-694[»]
ProteinModelPortaliQ59310.
SMRiQ59310.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ59310.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 236SialidaseInterPro annotationAdd BLAST187
Domaini428 – 615SialidasesInterPro annotationAdd BLAST188

Phylogenomic databases

eggNOGiENOG4108478. Bacteria.
COG4409. LUCA.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 2 hits.
PfamiPF13088. BNR_2. 1 hit.
PF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYKGITLIL TAAMVISGGN YVLVKGSTLD SGKNNSGYEI KVNNSENLSS
60 70 80 90 100
LGEYKDINLE SSNASNITYD LEKYKNLDEG TIVVRFNSKD SKIQSLLGIS
110 120 130 140 150
NSKTKNGYFN FYVTNSRVGF ELRNQKNEGN TQSGTENLVH MYKDVALNDG
160 170 180 190 200
DNTVALKIEK NKGYKLFLNG KIIKEVKDTN TKFLNNIENL DSAFIGKTNR
210 220 230 240 250
YGQSNEYNFK GNIGFMNIYN EPLGDDYLLS KTGETKAKEE VLVEGAVKTE
260 270 280 290 300
PVDLFHPGFL NSSNYRIPAL FKTKEGTLIA SIDARRHGGA DAPNNDIDTA
310 320 330 340 350
VRRSEDGGKT WDEGQIIMDY PDKSSVIDTT LIQDDETGRI FLLVTHFPSK
360 370 380 390 400
YGFWNAGLGS GFKNIDGKEY LCLYDSSGKE FTVRENVVYD KDGNKTEYTT
410 420 430 440 450
NALGDLFKNG TKIDNINSST APLKAKGTSY INLVYSDDDG KTWSEPQNIN
460 470 480 490 500
FQVKKDWMKF LGIAPGRGIQ IKNGEHKGRI VVPVYYTNEK GKQSSAVIYS
510 520 530 540 550
DDSGKNWTIG ESPNDNRKLE NGKIINSKTL SDDAPQLTEC QVVEMPNGQL
560 570 580 590 600
KLFMRNLSGY LNIATSFDGG ATWDETVEKD TNVLEPYCQL SVINYSQKVD
610 620 630 640 650
GKDAVIFSNP NARSRSNGTV RIGLINQVGT YENGEPKYEF DWKYNKLVKP
660 670 680 690
GYYAYSCLTE LSNGNIGLLY EGTPSEEMSY IEMNLKYLES GANK
Length:694
Mass (Da):77,327
Last modified:November 1, 1996 - v1
Checksum:i22D23E25A0A8DC72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87369 Genomic DNA. Translation: CAA60796.1.
PIRiI40866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87369 Genomic DNA. Translation: CAA60796.1.
PIRiI40866.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BF6X-ray0.97A243-691[»]
2VK5X-ray0.97A243-694[»]
2VK6X-ray1.50A243-694[»]
2VK7X-ray1.20A/B243-694[»]
ProteinModelPortaliQ59310.
SMRiQ59310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195103.CPF_0721.

Protein family/group databases

CAZyiCBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108478. Bacteria.
COG4409. LUCA.

Enzyme and pathway databases

BRENDAi3.2.1.18. 1503.

Miscellaneous databases

EvolutionaryTraceiQ59310.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 2 hits.
PfamiPF13088. BNR_2. 1 hit.
PF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59310_CLOPF
AccessioniPrimary (citable) accession number: Q59310
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.