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Q59310

- Q59310_CLOPF

UniProt

Q59310 - Q59310_CLOPF

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Protein
Submitted name:

Exo-alpha-sialidase

Gene

nanH

Organism
Clostridium perfringens
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi296 – 2961CalciumImported
Metal bindingi298 – 2981CalciumImported
Metal bindingi319 – 3191CalciumImported
Metal bindingi320 – 3201Calcium; via carbonyl oxygenImported

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseImported, Hydrolase

Keywords - Ligandi

CalciumImported, Metal-bindingImported

Protein family/group databases

CAZyiCBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Exo-alpha-sialidaseImported (EC:3.2.1.18Imported)
Gene namesi
Name:nanHImported
OrganismiClostridium perfringensImported
Taxonomic identifieri1502 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141 PotentialImportedAdd
BLAST
Chaini42 – 694653 PotentialImportedPRO_5000146477Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BF6X-ray0.97A243-691[»]
2VK5X-ray0.97A243-694[»]
2VK6X-ray1.50A243-694[»]
2VK7X-ray1.20A/B243-694[»]
ProteinModelPortaliQ59310.
SMRiQ59310. Positions 42-236, 243-690.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ59310.

Family & Domainsi

Keywords - Domaini

SignalImported

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59310-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYKGITLIL TAAMVISGGN YVLVKGSTLD SGKNNSGYEI KVNNSENLSS
60 70 80 90 100
LGEYKDINLE SSNASNITYD LEKYKNLDEG TIVVRFNSKD SKIQSLLGIS
110 120 130 140 150
NSKTKNGYFN FYVTNSRVGF ELRNQKNEGN TQSGTENLVH MYKDVALNDG
160 170 180 190 200
DNTVALKIEK NKGYKLFLNG KIIKEVKDTN TKFLNNIENL DSAFIGKTNR
210 220 230 240 250
YGQSNEYNFK GNIGFMNIYN EPLGDDYLLS KTGETKAKEE VLVEGAVKTE
260 270 280 290 300
PVDLFHPGFL NSSNYRIPAL FKTKEGTLIA SIDARRHGGA DAPNNDIDTA
310 320 330 340 350
VRRSEDGGKT WDEGQIIMDY PDKSSVIDTT LIQDDETGRI FLLVTHFPSK
360 370 380 390 400
YGFWNAGLGS GFKNIDGKEY LCLYDSSGKE FTVRENVVYD KDGNKTEYTT
410 420 430 440 450
NALGDLFKNG TKIDNINSST APLKAKGTSY INLVYSDDDG KTWSEPQNIN
460 470 480 490 500
FQVKKDWMKF LGIAPGRGIQ IKNGEHKGRI VVPVYYTNEK GKQSSAVIYS
510 520 530 540 550
DDSGKNWTIG ESPNDNRKLE NGKIINSKTL SDDAPQLTEC QVVEMPNGQL
560 570 580 590 600
KLFMRNLSGY LNIATSFDGG ATWDETVEKD TNVLEPYCQL SVINYSQKVD
610 620 630 640 650
GKDAVIFSNP NARSRSNGTV RIGLINQVGT YENGEPKYEF DWKYNKLVKP
660 670 680 690
GYYAYSCLTE LSNGNIGLLY EGTPSEEMSY IEMNLKYLES GANK
Length:694
Mass (Da):77,327
Last modified:November 1, 1996 - v1
Checksum:i22D23E25A0A8DC72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87369 Genomic DNA. Translation: CAA60796.1.
PIRiI40866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87369 Genomic DNA. Translation: CAA60796.1 .
PIRi I40866.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BF6 X-ray 0.97 A 243-691 [» ]
2VK5 X-ray 0.97 A 243-694 [» ]
2VK6 X-ray 1.50 A 243-694 [» ]
2VK7 X-ray 1.20 A/B 243-694 [» ]
ProteinModelPortali Q59310.
SMRi Q59310. Positions 42-236, 243-690.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi CBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q59310.

Family and domain databases

Gene3Di 2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
Pfami PF02973. Sialidase. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Gene structure of the 'large' sialidase isoenzyme from Clostridium perfringens A99 and its relationship with other clostridial nanH proteins."
    Traving C., Schauer R., Roggentin P.
    Glycoconj. J. 11:141-151(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A99Imported.
  2. Schauer R.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A99Imported.
  3. "The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates."
    Newstead S.L., Potter J.A., Wilson J.C., Xu G., Chien C.H., Watts A.G., Withers S.G., Taylor G.L.
    J. Biol. Chem. 283:9080-9088(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (0.97 ANGSTROMS) OF 243-691 IN COMPLEX WITH CALCIUM.

Entry informationi

Entry nameiQ59310_CLOPF
AccessioniPrimary (citable) accession number: Q59310
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3