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Q59310

- Q59310_CLOPF

UniProt

Q59310 - Q59310_CLOPF

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Protein
Submitted name:

Exo-alpha-sialidase

Gene
nanH
Organism
Clostridium perfringens
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi296 – 2961CalciumImported
Metal bindingi298 – 2981CalciumImported
Metal bindingi319 – 3191CalciumImported
Metal bindingi320 – 3201Calcium; via carbonyl oxygenImported

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseImported, Hydrolase

Keywords - Ligandi

CalciumImported, Metal-bindingImported

Protein family/group databases

CAZyiCBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Exo-alpha-sialidaseImported (EC:3.2.1.18Imported)
Gene namesi
Name:nanHImported
OrganismiClostridium perfringensImported
Taxonomic identifieri1502 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141 PredictedImportedAdd
BLAST
Chaini42 – 694653 PredictedImportedPRO_5000146477Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BF6X-ray0.97A243-691[»]
2VK5X-ray0.97A243-694[»]
2VK6X-ray1.50A243-694[»]
2VK7X-ray1.20A/B243-694[»]
ProteinModelPortaliQ59310.
SMRiQ59310. Positions 42-236, 243-690.

Miscellaneous databases

EvolutionaryTraceiQ59310.

Family & Domainsi

Keywords - Domaini

SignalImported

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR004124. Glyco_hydro_33_N.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59310-1 [UniParc]FASTAAdd to Basket

« Hide

MNYKGITLIL TAAMVISGGN YVLVKGSTLD SGKNNSGYEI KVNNSENLSS    50
LGEYKDINLE SSNASNITYD LEKYKNLDEG TIVVRFNSKD SKIQSLLGIS 100
NSKTKNGYFN FYVTNSRVGF ELRNQKNEGN TQSGTENLVH MYKDVALNDG 150
DNTVALKIEK NKGYKLFLNG KIIKEVKDTN TKFLNNIENL DSAFIGKTNR 200
YGQSNEYNFK GNIGFMNIYN EPLGDDYLLS KTGETKAKEE VLVEGAVKTE 250
PVDLFHPGFL NSSNYRIPAL FKTKEGTLIA SIDARRHGGA DAPNNDIDTA 300
VRRSEDGGKT WDEGQIIMDY PDKSSVIDTT LIQDDETGRI FLLVTHFPSK 350
YGFWNAGLGS GFKNIDGKEY LCLYDSSGKE FTVRENVVYD KDGNKTEYTT 400
NALGDLFKNG TKIDNINSST APLKAKGTSY INLVYSDDDG KTWSEPQNIN 450
FQVKKDWMKF LGIAPGRGIQ IKNGEHKGRI VVPVYYTNEK GKQSSAVIYS 500
DDSGKNWTIG ESPNDNRKLE NGKIINSKTL SDDAPQLTEC QVVEMPNGQL 550
KLFMRNLSGY LNIATSFDGG ATWDETVEKD TNVLEPYCQL SVINYSQKVD 600
GKDAVIFSNP NARSRSNGTV RIGLINQVGT YENGEPKYEF DWKYNKLVKP 650
GYYAYSCLTE LSNGNIGLLY EGTPSEEMSY IEMNLKYLES GANK 694
Length:694
Mass (Da):77,327
Last modified:November 1, 1996 - v1
Checksum:i22D23E25A0A8DC72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87369 Genomic DNA. Translation: CAA60796.1.
PIRiI40866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87369 Genomic DNA. Translation: CAA60796.1 .
PIRi I40866.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BF6 X-ray 0.97 A 243-691 [» ]
2VK5 X-ray 0.97 A 243-694 [» ]
2VK6 X-ray 1.50 A 243-694 [» ]
2VK7 X-ray 1.20 A/B 243-694 [» ]
ProteinModelPortali Q59310.
SMRi Q59310. Positions 42-236, 243-690.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi CBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q59310.

Family and domain databases

Gene3Di 2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR004124. Glyco_hydro_33_N.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
Pfami PF02973. Sialidase. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Gene structure of the 'large' sialidase isoenzyme from Clostridium perfringens A99 and its relationship with other clostridial nanH proteins."
    Traving C., Schauer R., Roggentin P.
    Glycoconj. J. 11:141-151(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A99Imported.
  2. Schauer R.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A99Imported.
  3. "The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates."
    Newstead S.L., Potter J.A., Wilson J.C., Xu G., Chien C.H., Watts A.G., Withers S.G., Taylor G.L.
    J. Biol. Chem. 283:9080-9088(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (0.97 ANGSTROMS) OF 243-691 IN COMPLEX WITH CALCIUM.

Entry informationi

Entry nameiQ59310_CLOPF
AccessioniPrimary (citable) accession number: Q59310
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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