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Q59310 (Q59310_CLOPF) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
EC=3.2.1.18 EMBL CAA60796.1
Gene names
Name:nanH EMBL CAA60796.1
OrganismClostridium perfringens EMBL CAA60796.1
Taxonomic identifier1502 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length694 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4141 Potential EMBL CAA60796.1
Chain42 – 694653 Potential EMBL CAA60796.1
PRO_5000146477

Sites

Metal binding2961Calcium PDB 2BF6 PDB 2VK5 PDB 2VK6 PDB 2VK7
Metal binding2981Calcium PDB 2BF6 PDB 2VK5 PDB 2VK6 PDB 2VK7
Metal binding3191Calcium PDB 2BF6 PDB 2VK5 PDB 2VK6 PDB 2VK7
Metal binding3201Calcium; via carbonyl oxygen PDB 2BF6 PDB 2VK5 PDB 2VK6 PDB 2VK7

Sequences

Sequence LengthMass (Da)Tools
Q59310 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 22D23E25A0A8DC72

FASTA69477,327
        10         20         30         40         50         60 
MNYKGITLIL TAAMVISGGN YVLVKGSTLD SGKNNSGYEI KVNNSENLSS LGEYKDINLE 

        70         80         90        100        110        120 
SSNASNITYD LEKYKNLDEG TIVVRFNSKD SKIQSLLGIS NSKTKNGYFN FYVTNSRVGF 

       130        140        150        160        170        180 
ELRNQKNEGN TQSGTENLVH MYKDVALNDG DNTVALKIEK NKGYKLFLNG KIIKEVKDTN 

       190        200        210        220        230        240 
TKFLNNIENL DSAFIGKTNR YGQSNEYNFK GNIGFMNIYN EPLGDDYLLS KTGETKAKEE 

       250        260        270        280        290        300 
VLVEGAVKTE PVDLFHPGFL NSSNYRIPAL FKTKEGTLIA SIDARRHGGA DAPNNDIDTA 

       310        320        330        340        350        360 
VRRSEDGGKT WDEGQIIMDY PDKSSVIDTT LIQDDETGRI FLLVTHFPSK YGFWNAGLGS 

       370        380        390        400        410        420 
GFKNIDGKEY LCLYDSSGKE FTVRENVVYD KDGNKTEYTT NALGDLFKNG TKIDNINSST 

       430        440        450        460        470        480 
APLKAKGTSY INLVYSDDDG KTWSEPQNIN FQVKKDWMKF LGIAPGRGIQ IKNGEHKGRI 

       490        500        510        520        530        540 
VVPVYYTNEK GKQSSAVIYS DDSGKNWTIG ESPNDNRKLE NGKIINSKTL SDDAPQLTEC 

       550        560        570        580        590        600 
QVVEMPNGQL KLFMRNLSGY LNIATSFDGG ATWDETVEKD TNVLEPYCQL SVINYSQKVD 

       610        620        630        640        650        660 
GKDAVIFSNP NARSRSNGTV RIGLINQVGT YENGEPKYEF DWKYNKLVKP GYYAYSCLTE 

       670        680        690 
LSNGNIGLLY EGTPSEEMSY IEMNLKYLES GANK 

« Hide

References

[1]"Gene structure of the 'large' sialidase isoenzyme from Clostridium perfringens A99 and its relationship with other clostridial nanH proteins."
Traving C., Schauer R., Roggentin P.
Glycoconj. J. 11:141-151(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A99 EMBL CAA60796.1.
[2]Schauer R.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A99 EMBL CAA60796.1.
[3]"The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates."
Newstead S.L., Potter J.A., Wilson J.C., Xu G., Chien C.H., Watts A.G., Withers S.G., Taylor G.L.
J. Biol. Chem. 283:9080-9088(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (0.97 ANGSTROMS) OF 243-691 IN COMPLEX WITH CALCIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87369 Genomic DNA. Translation: CAA60796.1.
PIRI40866.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BF6X-ray0.97A243-691[»]
2VK5X-ray0.97A243-694[»]
2VK6X-ray1.50A243-694[»]
2VK7X-ray1.20A/B243-694[»]
ProteinModelPortalQ59310.
SMRQ59310. Positions 42-236, 243-690.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyCBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR004124. Glyco_hydro_33_N.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERPTHR10628. PTHR10628. 1 hit.
PfamPF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
ProtoNetSearch...

Other

EvolutionaryTraceQ59310.

Entry information

Entry nameQ59310_CLOPF
AccessionPrimary (citable) accession number: Q59310
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)