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Protein

Dihydrolipoyl dehydrogenase

Gene
N/A
Organism
Clostridium magnum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
OrganismiClostridium magnumImported
Taxonomic identifieri33954 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliQ59299
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 77Lipoyl-bindingInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Family and domain databases

Gene3Di3.30.390.301 hit
3.50.50.603 hits
InterProiView protein in InterPro
IPR000089 Biotin_lipoyl
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006258 Lipoamide_DH
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00364 Biotin_lipoyl, 1 hit
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01350 lipoamide_DH, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q59299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIVVMPKL GLTMTEGTLV TWKKAEGDQV KVGEILFEVS TDKLTNEVES
60 70 80 90 100
SDEGIVRKLL VNEGDVVECL NPVAIIGSAD EDISSLLNGS SEGSGSAEQS
110 120 130 140 150
DTKAPKKEVE AVKGGDNLVV IGGGPGGYVA AIRAAQLGAK VTLIEKESLG
160 170 180 190 200
GTCLNVGCIP TKVLLHSSQL LTEMKEGDKL GIDIEGSIVV NWKHIQKRKK
210 220 230 240 250
IVIKKLVSGV SGLLTCNKVK VIKGTAKFES KDTILVTKED GVAEKVNFDN
260 270 280 290 300
AIIATGSMPF IPEIEGNKLS GVIDSTGALS LESNPESIAI IGGGVIGVEF
310 320 330 340 350
ASIFNSLGCK VSIIEMLPHI LPPMDREISE IAKAKLIRDG ININNNCKVT
360 370 380 390 400
RIEQGEDGLK VSFIGDKGEE SIDVEKVLIA VGRRSNIEGL DVEKIGVKTE
410 420 430 440 450
GGSIIVNDKM ETNVEGIYAI GDCTGKIMLA HVASDQGVVA AENIMGQNKK
460 470 480 490 500
MDYKTVPACV YTKPELASVG LTEEQAKEKG IDYKVGKFQL AANGKSLIMN
510 520 530 540 550
ETGGVIKIIT DKKYEEILGV HILGPRATDL ITEAALALRL EATLEEIITT
560 570
VHAHPTVGEA MKEAALAVNN QAIHMMNK
Length:578
Mass (Da):61,342
Last modified:November 1, 1996 - v1
Checksum:i31848A84AE2903E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31844 Genomic DNA Translation: AAA21748.1
PIRiI40794

Similar proteinsi

Entry informationi

Entry nameiQ59299_9CLOT
AccessioniPrimary (citable) accession number: Q59299
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)