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Protein

Catalase

Gene

katA

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52By similarity1
Active sitei124By similarity1
Metal bindingi334Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-1308-MONOMER.

Protein family/group databases

PeroxiBasei5383. CjejKat01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:katA
Ordered Locus Names:Cj1385
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849831 – 507CatalaseAdd BLAST507

Proteomic databases

PaxDbiQ59296.

Interactioni

Protein-protein interaction databases

IntActiQ59296. 37 interactors.
STRINGi192222.Cj1385.

Structurei

3D structure databases

ProteinModelPortaliQ59296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiENOG4105CH6. Bacteria.
COG0753. LUCA.
HOGENOMiHOG000087852.
KOiK03781.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLTNDFGN IIADNQNSLS AGTKGPLLMQ DYLLLEKLAH QNRERIPERT
60 70 80 90 100
VHAKGSGAYG EIKITADLSA YTKAKIFQKG EITPLFLRFS TVAGEAGAAD
110 120 130 140 150
AERDVRGFAI KFYTKEGNWD LVGNNTPTFF IRDAYKFPDF IHTQKRDPRT
160 170 180 190 200
HLRSNNAAWD FWSLCPESLH QVTILMRDRG IPASYRHMHG FGSHTYSFIN
210 220 230 240 250
DKNERFWVKF HFKTQQGIKN LTNQEAAELI AKDRESHQRD LYNAIENKDF
260 270 280 290 300
PKWKVQVQIL AEKDIEKLGF NPFDLTKIWP HSLVPLMDIG EMILNKNPQN
310 320 330 340 350
YFNEVEQAAF SPSNIVPGIG FSPDKMLQAR IFSYPDAQRY RIGTNYHLLP
360 370 380 390 400
VNRAKSEVNT YNVAGAMNFD SYKNDAAYYE PNSYDNSPKE DKSYLEPDLV
410 420 430 440 450
LEGVAQRYAP LDNDFYTQPR ALFNLMNDDQ KTQLFHNIAT SMEGVDEKII
460 470 480 490 500
TRALEHFEKI SPDYAKGIKK AFPIVSRIRA WRNHGHRCFL CEIVIRSQFH

TTYEPEA
Length:507
Mass (Da):58,416
Last modified:November 1, 1996 - v1
Checksum:iB1320894668E867E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23T → A in CAL35497 (PubMed:10688204).Curated1
Sequence conflicti82I → V in CAL35497 (PubMed:10688204).Curated1
Sequence conflicti177R → S in CAL35497 (PubMed:10688204).Curated1
Sequence conflicti283L → F in CAL35497 (PubMed:10688204).Curated1
Sequence conflicti440T → A in CAL35497 (PubMed:10688204).Curated1
Sequence conflicti455E → K in CAL35497 (PubMed:10688204).Curated1
Sequence conflicti472 – 507FPIVS…YEPEA → LEK in CAL35497 (PubMed:10688204).CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85130 Genomic DNA. Translation: CAA59444.1.
AL111168 Genomic DNA. Translation: CAL35497.1.
PIRiF81283.
I40767.
RefSeqiYP_002344773.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL35497; CAL35497; Cj1385.
GeneIDi905678.
KEGGicje:Cj1385.
PATRICi20059735. VBICamJej33762_1366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85130 Genomic DNA. Translation: CAA59444.1.
AL111168 Genomic DNA. Translation: CAL35497.1.
PIRiF81283.
I40767.
RefSeqiYP_002344773.1. NC_002163.1.

3D structure databases

ProteinModelPortaliQ59296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ59296. 37 interactors.
STRINGi192222.Cj1385.

Protein family/group databases

PeroxiBasei5383. CjejKat01.

Proteomic databases

PaxDbiQ59296.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL35497; CAL35497; Cj1385.
GeneIDi905678.
KEGGicje:Cj1385.
PATRICi20059735. VBICamJej33762_1366.

Phylogenomic databases

eggNOGiENOG4105CH6. Bacteria.
COG0753. LUCA.
HOGENOMiHOG000087852.
KOiK03781.

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-1308-MONOMER.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATA_CAMJE
AccessioniPrimary (citable) accession number: Q59296
Secondary accession number(s): Q0P8M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.