Q59296 (CATA_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catalase
EC=1.11.1.6

Gene names

Name:	katA
Ordered Locus Names:	Cj1385

Organism

Campylobacter jejuni

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H2O2 = O2 + 2 H2O.
Cofactor	Heme group.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Catalase		PRO_0000084983
Sites
	Active site	52	1	By similarity
	Active site	124	1	By similarity
	Metal binding	334	1	Iron (heme axial ligand) By similarity
Experimental info
	Sequence conflict	23	1	T → A in CAL35497. Ref.2
	Sequence conflict	82	1	I → V in CAL35497. Ref.2
	Sequence conflict	177	1	R → S in CAL35497. Ref.2
	Sequence conflict	283	1	L → F in CAL35497. Ref.2
	Sequence conflict	440	1	T → A in CAL35497. Ref.2
	Sequence conflict	455	1	E → K in CAL35497. Ref.2
	Sequence conflict	472 – 507	36	FPIVS…YEPEA → LEK in CAL35497. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q59296 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B1320894668E867E	FASTA	507	58,416
	10 20 30 40 50 60 MKKLTNDFGN IIADNQNSLS AGTKGPLLMQ DYLLLEKLAH QNRERIPERT VHAKGSGAYG 70 80 90 100 110 120 EIKITADLSA YTKAKIFQKG EITPLFLRFS TVAGEAGAAD AERDVRGFAI KFYTKEGNWD 130 140 150 160 170 180 LVGNNTPTFF IRDAYKFPDF IHTQKRDPRT HLRSNNAAWD FWSLCPESLH QVTILMRDRG 190 200 210 220 230 240 IPASYRHMHG FGSHTYSFIN DKNERFWVKF HFKTQQGIKN LTNQEAAELI AKDRESHQRD 250 260 270 280 290 300 LYNAIENKDF PKWKVQVQIL AEKDIEKLGF NPFDLTKIWP HSLVPLMDIG EMILNKNPQN 310 320 330 340 350 360 YFNEVEQAAF SPSNIVPGIG FSPDKMLQAR IFSYPDAQRY RIGTNYHLLP VNRAKSEVNT 370 380 390 400 410 420 YNVAGAMNFD SYKNDAAYYE PNSYDNSPKE DKSYLEPDLV LEGVAQRYAP LDNDFYTQPR 430 440 450 460 470 480 ALFNLMNDDQ KTQLFHNIAT SMEGVDEKII TRALEHFEKI SPDYAKGIKK AFPIVSRIRA 490 500 WRNHGHRCFL CEIVIRSQFH TTYEPEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of katA from Campylobacter jejuni and generation of a catalase-deficient mutant of Campylobacter coli by interspecific allelic exchange." Grant K.A., Park S.F. Microbiology 141:1369-1376(1995) [PubMed: 7670638] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 33560 / CIP 702 / DSM 4688 / NCTC 11351.
[2]	"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85130 Genomic DNA. Translation: CAA59444.1. AL111168 Genomic DNA. Translation: CAL35497.1.
PIR	F81283. I40767.
RefSeq	YP_002344773.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q59296.
SMR	Q59296. Positions 2-474.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q59296. 39 interactions.
Protein family/group databases
PeroxiBase	5383. CjejKat01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	905678.
GenomeReviews	Gene locus Cj1385 in contig AL111168_GR.
KEGG	cje:Cj1385.
PATRIC	20059735. VBICamJej33762_1366.
Phylogenomic databases
HOGENOM	HBG339355.
ProtClustDB	CLSK879231.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ1385-MONOMER.
Family and domain databases
InterPro	IPR018028. Catalase. IPR020835. Catalase-like_dom. IPR024711. Catalase_clade1/3. IPR011614. Catalase_core. IPR002226. Catalase_haem_BS. IPR010582. Catalase_immune_responsive. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
KO	K03781.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PIRSF	PIRSF038928. Catalase_clade1-3. 1 hit.
PRINTS	PR00067. CATALASE.
SMART	SM01060. Catalase. 1 hit. [Graphical view]
SUPFAM	SSF56634. Catalase_N. 1 hit.
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. False negative. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_CAMJE

Accession

Primary (citable) accession number: Q59296
Secondary accession number(s): Q0P8M4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program