Reviewed, UniProtKB/Swiss-Prot Q59224 (DHPH_BACBA)

Names and origin

Protein names

Recommended name:
    Phenylalanine dehydrogenase
      Short name=PheDH
    EC=1.4.1.20

Gene names

Name:

pdh

Organism

Bacillus badius

Taxonomic identifier

1455 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH.
Pathway	Amino-acid biosynthesis; L-phenylalanine biosynthesis; L-phenylalanine from phenylpyruvate (PDH route): step 1/1.
Sequence similarities	Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro phenylalanine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Phenylalanine dehydrogenase		PRO_0000182806
Regions
	Nucleotide binding	190 – 196	7	NAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59224-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: ABB94657BA6A109A	FASTA	380	41,353
	10 20 30 40 50 60 MSLVEKTSII KDFTLFEKMS EHEQVVFCND PATGLRAIIA IHDTTLGPAL GGCRMQPYNS 70 80 90 100 110 120 VEEALEDALR LSKGMTYKCA ASDVDFGGGK AVIIGDPQKD KSPELFRAFG QFVDSLGGRF 130 140 150 160 170 180 YTGTDMGTNM EDFIHAMKET NCIVGVPEAY GGGGDSSIPT AMGVLYGIKA TNKMLFGKDD 190 200 210 220 230 240 LGGVTYAIQG LGKVGYKVAE GLLEEGAHLF VTDINEQTLE AIQEKAKTTS GSVTVVASDE 250 260 270 280 290 300 IYSQEADVFV PCAFGGVVND ETMKQFKVKA IAGSANNQLL TEDHGRHLAD KGILYAPDYI 310 320 330 340 350 360 VNSGGLIQVA DELYEVNKER VLAKTKHIYD AILEVYQQAE LDQITTMEAA NRMCEQRMAA 370 380 RGRRNSFFTS SVKPKWDIRN

References

[1]	"Nucleotide sequencing of phenylalanine dehydrogenase gene from Bacillus badius IAM 11059." Yamada A., Dairi T., Ohno Y., Huang X., Asano Y. Biosci. Biotechnol. Biochem. 59:1994-1995(1995) [PubMed: 8535000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IAM 11059.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D50261 Genomic DNA. Translation: BAA08816.1.
PIR	JC4328.
3D structure databases
HSSP	HSSP built from PDB template 1C1D based on UniProtKB Q59771.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.4.1.20. 229848.
Family and domain databases
InterPro	IPR006095. Glu/Leu/Phe/Val_DH. IPR006096. Glu/Leu/Phe/Val_DH_C. IPR006097. Glu/Leu/Phe/Val_DH_dimer. IPR016211. Glu/Phe/Leu/Val_DH_bac/arc. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00208. ELFV_dehydrog. 1 hit. PF02812. ELFV_dehydrog_N. 1 hit. [Graphical view]
PIRSF	PIRSF000188. Phe_leu_dh. 1 hit.
PRINTS	PR00082. GLFDHDRGNASE.
PROSITE	PS00074. GLFV_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHPH_BACBA

Accession

Primary (citable) accession number: Q59224

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	September 22, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)