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Protein

Phenylalanine dehydrogenase

Gene

pdh

Organism
Bacillus badius
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible, NAD-dependent deamination of L-phenylalanine to phenyl pyruvate, ammonia and NADH.By similarity

Catalytic activityi

L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH.By similarity

Pathwayi: L-phenylalanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-phenylalanine from phenylpyruvate (PDH route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Phenylalanine dehydrogenase (pdh)
This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-phenylalanine from phenylpyruvate (PDH route), the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541NADBy similarity
Binding sitei78 – 781SubstrateBy similarity
Active sitei90 – 901Proton donor/acceptorBy similarity
Binding sitei125 – 1251NADBy similarity
Binding sitei156 – 1561NADBy similarity
Binding sitei160 – 1601NADBy similarity
Binding sitei276 – 2761SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi190 – 1967NADBy similarity
Nucleotide bindingi213 – 2142NADBy similarity
Nucleotide bindingi253 – 2542NADBy similarity
Nucleotide bindingi274 – 2763NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

SABIO-RKQ59224.
UniPathwayiUPA00121; UER00346.

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine dehydrogenase1 Publication (EC:1.4.1.20By similarity)
Short name:
PheDH1 Publication
Gene namesi
Name:pdh1 Publication
OrganismiBacillus badius
Taxonomic identifieri1455 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 380379Phenylalanine dehydrogenasePRO_0000182806Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ59224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR016211. Glu/Phe/Leu/Val_DH_bac/arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11606:SF3. PTHR11606:SF3. 1 hit.
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000188. Phe_leu_dh. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVEKTSII KDFTLFEKMS EHEQVVFCND PATGLRAIIA IHDTTLGPAL
60 70 80 90 100
GGCRMQPYNS VEEALEDALR LSKGMTYKCA ASDVDFGGGK AVIIGDPQKD
110 120 130 140 150
KSPELFRAFG QFVDSLGGRF YTGTDMGTNM EDFIHAMKET NCIVGVPEAY
160 170 180 190 200
GGGGDSSIPT AMGVLYGIKA TNKMLFGKDD LGGVTYAIQG LGKVGYKVAE
210 220 230 240 250
GLLEEGAHLF VTDINEQTLE AIQEKAKTTS GSVTVVASDE IYSQEADVFV
260 270 280 290 300
PCAFGGVVND ETMKQFKVKA IAGSANNQLL TEDHGRHLAD KGILYAPDYI
310 320 330 340 350
VNSGGLIQVA DELYEVNKER VLAKTKHIYD AILEVYQQAE LDQITTMEAA
360 370 380
NRMCEQRMAA RGRRNSFFTS SVKPKWDIRN
Length:380
Mass (Da):41,353
Last modified:November 1, 1996 - v1
Checksum:iABB94657BA6A109A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50261 Genomic DNA. Translation: BAA08816.1.
PIRiJC4328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50261 Genomic DNA. Translation: BAA08816.1.
PIRiJC4328.

3D structure databases

ProteinModelPortaliQ59224.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00121; UER00346.
SABIO-RKQ59224.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR016211. Glu/Phe/Leu/Val_DH_bac/arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11606:SF3. PTHR11606:SF3. 1 hit.
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000188. Phe_leu_dh. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHPH_BACBA
AccessioniPrimary (citable) accession number: Q59224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.