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Q59191 (RPOB_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase subunit beta
Short name=RNAP subunit beta
EC=2.7.7.6
Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta
Gene names
Name:rpoB
Ordered Locus Names:BB_0389
OrganismBorrelia burgdorferi (Lyme disease spirochete)
Taxonomic identifier139 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length1155 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01321

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01321

Subunit structure

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentDNA-directed RNA polymerase
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionDNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

ribonucleoside binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11551155DNA-directed RNA polymerase subunit beta HAMAP MF_01321
PRO_0000047866

Experimental info

Sequence conflict39 – 402KS → EKV in AAC37118. Ref.1
Sequence conflict781D → V in AAC37118. Ref.1
Sequence conflict1291G → A in AAC37118. Ref.1
Sequence conflict180 – 1845DYLYV → IIFIE in AAC37118. Ref.1
Sequence conflict191 – 1933RIL → EYV in AAC37118. Ref.1
Sequence conflict3061G → A in AAC37118. Ref.1
Sequence conflict3161M → S in AAC37118. Ref.1
Sequence conflict566 – 5672KC → NV in AAC37118. Ref.1
Sequence conflict573 – 5742AA → RR in AAC37118. Ref.1
Sequence conflict580 – 5812KY → ND in AAC37118. Ref.1
Sequence conflict869 – 89123VPHGT…DVGNL → FLMVLKVLLLMFKGLPKRIL VS in AAC37118. Ref.1
Sequence conflict898 – 9036ILKVYV → NLSSLA in AAC37118. Ref.1
Sequence conflict1078 – 10858AAHTLQEL → RRTPSRT in AAC37118. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q59191 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 1295040746D73173

FASTA1,155129,624
        10         20         30         40         50         60 
MIKRVHLGQG RADEILDLPN LIEIQLNSYE KFLQLDKLKS KKPLLNEGLE SVFRNIFPIK 

        70         80         90        100        110        120 
SGNGDVALEY ERYYIENDAL NFTEKECKRK GQSYEAVLKV RLNLQFLTTG EIRQKDVYMG 

       130        140        150        160        170        180 
TIPLMTERGT FIINGAERVV VSQIHRSPGV VFYKEKDLYS ARIIPYRGSW LEFEIDSKKD 

       190        200        210        220        230        240 
YLYVKIDRKK RILITLFLRA LGFDTREKII ETFYNIKKIK VEDGTKRDLP GQYLAKSINI 

       250        260        270        280        290        300 
RENMYYRAGD KITLQDVEDF LQNGVNEIEL VDFDGYNDIS GKRFVSSNVI LNCLEKEDAF 

       310        320        330        340        350        360 
FALKDGSKEL PKESVMLAVY GSLFPGEPIS IDNAENDLKT IFFSERRYDL GRVGRYKLSK 

       370        380        390        400        410        420 
KFGFDDLTTS VLTMDDIVNT ISHLLRIYEG HDILDDIDHL GNRRVRSVGE LLTNIYKGAM 

       430        440        450        460        470        480 
SRVEKIAKDR MSNKEVFNLK PQELISVKPI VSAVKEFFAT SQLSQFMDQV NPLAELTHKR 

       490        500        510        520        530        540 
RLNALGPGGL SRDRAGFEVR DVHYTHYGRM CPIETPEGPN IGLIVSLATY SRVNDYGFLE 

       550        560        570        580        590        600 
TPYRKVVNGV VTDQLEYLSA IDEEKKCIAQ ANAAFNSNGK YLEDLVSVRI SGDYTTTSPT 

       610        620        630        640        650        660 
NIDYMDVSPR QLISVSSALI PFLEHNDANR ALMGSNMQRQ AVPLLFPKPP IVGTGMESVV 

       670        680        690        700        710        720 
AKDSGVVVKA KRSGEVILAT SSKIVVKPFE AENAKDLDEY HIVKYERTNQ DTCFNQSVLV 

       730        740        750        760        770        780 
KEGQKVERGE IIADGPATRY GELALGNNLL LGVIPWNGFN YEDAILISDR IVKEDLYTSI 

       790        800        810        820        830        840 
HIKEFSIEVR ETKLGPEKVT GDIPNVSEKI LNKLDENGII RIGTYVKPGD ILVGKVTPKS 

       850        860        870        880        890        900 
EGDITPEFRL LTSIFGEKAK DVKNNSLKVP HGTEGTVIDV QRITKEDVGN LSPGVEEILK 

       910        920        930        940        950        960 
VYVAKKRKLK EGDKMAGRHG NKGVVAKILP VEDMPYLADG TPLDICLNPL GVPSRMNIGQ 

       970        980        990       1000       1010       1020 
LMESQLGLAG KYLGESYNVP VFESATNEQI QEKLKTAGFN PTSKEILYDG YTGEPFENEV 

      1030       1040       1050       1060       1070       1080 
MVGVIYMLKL HHLVDDKMHA RSTGPYSLVS QQPLGGKAQF GGQRLGEMEV WALEAYGAAH 

      1090       1100       1110       1120       1130       1140 
TLQELLTVKS DDMSGRVKIY ENIVKGVPTN VSGIPESFNV LMQELRGLGL DLSIYDDAGN 

      1150 
QVPLTEKEEE LINKS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L48488 Genomic DNA. Translation: AAC37118.1.
AE000783 Genomic DNA. Translation: AAB91501.1.
PIRD70148.
RefSeqNP_212523.1. NC_001318.1.

3D structure databases

ProteinModelPortalQ59191.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000009122; EBBORP00000008452; EBBORG00000009121.
GeneID1195226.
GenomeReviewsGene locus BB_0389 in contig AE000783_GR.
KEGGbbu:BB0389.
NMPDRfig|224326.1.peg.773.
PATRIC20557388. VBIBorBur75917_0784.
TIGRBB_0389.

Phylogenomic databases

GeneTreeEBGT00050000007339.
HOGENOMHBG285547.
OMAVDARDTK.
PhylomeDBQ59191.
ProtClustDBPRK00405.

Enzyme and pathway databases

BioCycBBUR224326:BB_0389-MONOMER.

Family and domain databases

HAMAPMF_01321. RNApol_bact_RpoB.
[Tree]
InterProIPR010243. DNA-dir_RNA_pol_bsu_bac-type.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
Gene3DG3DSA:2.30.150.10. G3DSA:2.30.150.10. 1 hit.
G3DSA:2.40.270.10. G3DSA:2.40.270.10. 2 hits.
G3DSA:2.40.50.150. Ribosomal_L2. 1 hit.
KOK03043.
PANTHERPTHR20856:SF3. PTHR20856:SF3. 1 hit.
PTHR20856. RNA_pol_I_sub2. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsTIGR02013. RpoB. 1 hit.
PROSITEPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPOB_BORBU
AccessionPrimary (citable) accession number: Q59191
Secondary accession number(s): O51350
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: January 25, 2012
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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