Q59190 (URK_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uridine kinase
EC=2.7.1.48

Alternative name(s):
Cytidine monophosphokinase
Uridine monophosphokinase

Gene names

Name:	udk
Ordered Locus Names:	BB_0015

Organism

Borrelia burgdorferi (Lyme disease spirochete)

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + uridine = ADP + UMP. HAMAP MF_00551 ATP + cytidine = ADP + CMP. HAMAP MF_00551
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP MF_00551 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP MF_00551
Subunit structure	Monomer.
Subcellular location	Cytoplasm By similarity HAMAP MF_00551.
Sequence similarities	Belongs to the uridine kinase family.
Sequence caution	The sequence AAC66392.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 206	205	Uridine kinase HAMAP MF_00551		PRO_0000164465
Regions
	Nucleotide binding	9 – 16	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59190 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 2BB6A0075CB823E1	FASTA	206	23,874
	10 20 30 40 50 60 MAKIIGISGG SGSGKTTVVS KISEFIPEFV LISQDNYYKS VGDYEHEFSK VNFDHPDAFD 70 80 90 100 110 120 NNLFYEHLKN LKKNSPIDMP LYDFINHKRQ LKTVLVVPTP VVIVEGIMIF VEERVRNLID 130 140 150 160 170 180 LKIYIDTPND IRFIRRLRRD ISKRGRTVES VIDQYLNTTR WGYYRFIEPT KEYADLIIPE 190 200 GGHNDKALYV LSTFLKSLSK EGLDFT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Borrelia burgdorferi uridine kinase: an enzyme of the pyrimidine salvage pathway for endogenous use of nucleotides." Boursaux-Eude C., Margarita D., Gilles A.M., Barzu O., Saint-Girons I. FEMS Microbiol. Lett. 151:257-261(1997) [PubMed: 9228761] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-5. Strain: HB19.
[2]	"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97449 Genomic DNA. Translation: CAA66081.1. AE000783 Genomic DNA. Translation: AAC66392.1. Different initiation.
PIR	G70101.
RefSeq	NP_212149.1. NC_001318.1.
3D structure databases
ProteinModelPortal	Q59190.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000008420; EBBORP00000007750; EBBORG00000008419.
GeneID	1194851.
GenomeReviews	Gene locus BB_0015 in contig AE000783_GR.
KEGG	bbu:BB0015.
NMPDR	fig|224326.1.peg.399.
PATRIC	20556633. VBIBorBur75917_0413.
TIGR	BB_0015.
Phylogenomic databases
GeneTree	EBGT00050000007051.
HOGENOM	HBG527126.
OMA	NQFVEPT.
PhylomeDB	Q59190.
ProtClustDB	PRK05480.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0015-MONOMER.
Family and domain databases
HAMAP	MF_00551. Uridine_kinase. [Tree]
InterPro	IPR006083. PRK/URK. IPR000764. Uridine_kinase. [Graphical view]
KO	K00876.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. Udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URK_BORBU

Accession

Primary (citable) accession number: Q59190

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 82 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program