Q59188 (PLSC_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-acyl-sn-glycerol-3-phosphate acyltransferase
Short name=1-AGP acyltransferase
Short name=1-AGPAT
EC=2.3.1.51

Alternative name(s):
Lysophosphatidic acid acyltransferase
Short name=LPAAT

Gene names

Name:	plsC
Ordered Locus Names:	BB_0037

Organism

Borrelia burgdorferi (Lyme disease spirochete)

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	1-acyl-sn-glycerol-3-phosphate acyltransferase		PRO_0000208167
Regions
	Motif	88 – 93	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	Q59188 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: A730BED7058AD999	FASTA	250	28,581
	10 20 30 40 50 60 MIIVFMKILR SIITYFNVLL FFLILIFFLF PFYLVCKIFL IERYVVRLSF IMMRACIKIS 70 80 90 100 110 120 LWLAGIKIIV TGSENIPKKS NVIIMGNHIA AMDPLIFIYT FACPFVILAK HSLLRIPFVN 130 140 150 160 170 180 IVLIVMGVIF VNRRSIRSAA AAEVKAIKVM REGRSIGIFP EGTRNRGGDT RVFKKGSIKM 190 200 210 220 230 240 ALKTGTSILP VTLYNTNNFF IKNIIFNSGL SVYIHVHPLI DVLKLSEYEK ENLTSIIRDQ 250 IVKKLETIKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[2]	"Conservation of gene arrangement and an unusual organization of rRNA genes in the linear chromosomes of the Lyme disease spirochaetes Borrelia burgdorferi, B. garinii and B. afzelii." Ojaimi C., Davidson B.E., Saint-Girons I., Old I.G. Microbiology 140:2931-2940(1994) [PubMed: 7812434] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 116-250. Strain: 212.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000783 Genomic DNA. Translation: AAC66417.1. L32861 Genomic DNA. Translation: AAC41407.1.
PIR	E70104.
RefSeq	NP_212171.1. NC_001318.1.
3D structure databases
ProteinModelPortal	Q59188.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000008608; EBBORP00000007938; EBBORG00000008607.
GeneID	1194873.
GenomeReviews	Gene locus BB_0037 in contig AE000783_GR.
KEGG	bbu:BB0037.
NMPDR	fig|224326.1.peg.421.
PATRIC	20556679. VBIBorBur75917_0436.
TIGR	BB_0037.
Phylogenomic databases
GeneTree	EBGT00050000006883.
HOGENOM	HBG354607.
OMA	LERYVIR.
PhylomeDB	Q59188.
ProtClustDB	CLSK507308.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0037-MONOMER.
Family and domain databases
InterPro	IPR002123. Acyltransferase. IPR004552. AGP_acyltrans. [Graphical view]
KO	K00655.
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00530. AGP_acyltrn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLSC_BORBU

Accession

Primary (citable) accession number: Q59188

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	January 25, 2012
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program