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Q59185 (LON1_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lon protease 1

EC=3.4.21.53
Alternative name(s):
ATP-dependent protease La 1
Gene names
Name:lon1
Ordered Locus Names:BB_0253
OrganismBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]
Taxonomic identifier224326 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length806 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner By similarity. HAMAP-Rule MF_01973

Catalytic activity

Hydrolysis of proteins in presence of ATP. HAMAP-Rule MF_01973

Subunit structure

Homohexamer. Organized in a ring with a central cavity By similarity.

Subcellular location

Cytoplasm HAMAP-Rule MF_01973.

Induction

By heat shock By similarity. HAMAP-Rule MF_01973

Sequence similarities

Belongs to the peptidase S16 family.

Contains 1 Lon domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 806806Lon protease 1 HAMAP-Rule MF_01973
PRO_0000076118

Regions

Domain31 – 231201Lon
Nucleotide binding389 – 3968ATP By similarity

Sites

Active site7141 By similarity
Active site7571 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q59185 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 71F488D719B1424E

FASTA80690,710
        10         20         30         40         50         60 
MDESKKARSG DKKKEKAVAG ILPHSNKPAR VPLIAVPSHP VFPGMFIPIV LISDSDMKAI 

        70         80         90        100        110        120 
DYAMKGNGII ALFVLNDKFL EKNNNNAQQK LIIDYSKDIY SVGVTGKIIK KINLPDGGYN 

       130        140        150        160        170        180 
IFVSTFDRIK FVKVVLNDKF PIIEIDYLKQ IPVRKDDIQS KAVYGSILLR TKEIFAHRKM 

       190        200        210        220        230        240 
PEVQLNMVNI EDKGKLCDIV ASTISSSKND HQIVLETLNV KDRLKKVLEL IYEELNLIEI 

       250        260        270        280        290        300 
QNKIAKGIQE RLEKQQKEFF LKEQLKAIKA ELGIGDKKSS DLEKLKTKLK ALELKGEPLE 

       310        320        330        340        350        360 
VVEKELEKFS LLETSSAEYI VVRNYLELIT ELPWRDFKIN FDKLDLQKSK KILDKTHYGM 

       370        380        390        400        410        420 
NEVKDRIIEY ISVLKLRKTQ KGAIILLVGP PGVGKTSIGA AIAKVLRTKF FRFSVGGMRD 

       430        440        450        460        470        480 
ESEIKGHRRT YVGALPGKII QGLRITKTNS PVFLIDEVDK ISASSYGDPF SVLLEVLDPE 

       490        500        510        520        530        540 
QNVRFRDHYL DLPFDISNVF FILTANSVET IPRPLLNRME IIEISGYIDN EKIEIARKYL 

       550        560        570        580        590        600 
IPKVLSENGV DKDSLKFQSS SLVQIAQEYA RDNGVRNFEK YLNKIVRKVA RKLIENTEVK 

       610        620        630        640        650        660 
SYQISNDNLE EYVGVPVFRK ESMPNAMYSG MVMGLAWTNY GGSTLMIETV KTESKVGGIK 

       670        680        690        700        710        720 
LTGRLGDVMK ESANIAYTYV NSIKGDLSIS KSFFEKNIIH LHIPEGATPK DGPSAGITIA 

       730        740        750        760        770        780 
SAFISLALNK VVRPHLAMTG ELSLTGNVMM IGGLKEKIIA AKRSGVEHII VPKANRVDLE 

       790        800 
EIPTNIKSGI NFYLVDNMRE VIKLLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77216 Genomic DNA. Translation: AAB72011.1.
AE000783 Genomic DNA. Translation: AAB91493.1.
PIRE70131.
RefSeqNP_212387.1. NC_001318.1.

3D structure databases

ProteinModelPortalQ59185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224326.BB0253.

Proteomic databases

PRIDEQ59185.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB91493; AAB91493; BB_0253.
GeneID1195090.
KEGGbbu:BB_0253.
PATRIC20557124. VBIBorBur75917_0652.

Phylogenomic databases

eggNOGCOG0466.
KOK01338.
OMAILDKTHY.
OrthoDBEOG6XHC23.
ProtClustDBCLSK544900.

Enzyme and pathway databases

BioCycBBUR224326:G9SO-253-MONOMER.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_01973. lon_bact.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR10046. PTHR10046. 1 hit.
PfamPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFPIRSF001174. Lon_proteas. 1 hit.
SMARTSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsTIGR00763. lon. 1 hit.
PROSITEPS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLON1_BORBU
AccessionPrimary (citable) accession number: Q59185
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries