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Q59185

- LON1_BORBU

UniProt

Q59185 - LON1_BORBU

Protein

Lon protease 1

Gene

lon1

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

    Catalytic activityi

    Hydrolysis of proteins in presence of ATP.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei714 – 7141UniRule annotation
    Active sitei757 – 7571UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi389 – 3968ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. ATP-dependent peptidase activity Source: UniProtKB-HAMAP
    3. sequence-specific DNA binding Source: UniProtKB-HAMAP
    4. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular response to stress Source: UniProtKB-HAMAP
    2. misfolded or incompletely synthesized protein catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBBUR224326:G9SO-253-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lon protease 1UniRule annotation (EC:3.4.21.53UniRule annotation)
    Alternative name(s):
    ATP-dependent protease La 1UniRule annotation
    Gene namesi
    Name:lon1UniRule annotation
    Ordered Locus Names:BB_0253
    OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    Taxonomic identifieri224326 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001807: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 806806Lon protease 1PRO_0000076118Add
    BLAST

    Proteomic databases

    PRIDEiQ59185.

    Expressioni

    Inductioni

    By heat shock.UniRule annotation

    Interactioni

    Subunit structurei

    Homohexamer. Organized in a ring with a central cavity.UniRule annotation

    Protein-protein interaction databases

    STRINGi224326.BB0253.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 231201LonUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S16 family.UniRule annotation
    Contains 1 Lon domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0466.
    KOiK01338.
    OMAiDSLKFQS.
    OrthoDBiEOG6XHC23.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_01973. lon_bact.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR027543. Lon_bac.
    IPR004815. Lon_bac/euk-typ.
    IPR027065. Lon_Prtase.
    IPR027417. P-loop_NTPase.
    IPR008269. Pept_S16_C.
    IPR003111. Pept_S16_N.
    IPR008268. Peptidase_S16_AS.
    IPR015947. PUA-like_domain.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR10046. PTHR10046. 1 hit.
    PfamiPF00004. AAA. 1 hit.
    PF02190. LON. 1 hit.
    PF05362. Lon_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001174. Lon_proteas. 1 hit.
    SMARTiSM00382. AAA. 1 hit.
    SM00464. LON. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsiTIGR00763. lon. 1 hit.
    PROSITEiPS01046. LON_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59185-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDESKKARSG DKKKEKAVAG ILPHSNKPAR VPLIAVPSHP VFPGMFIPIV    50
    LISDSDMKAI DYAMKGNGII ALFVLNDKFL EKNNNNAQQK LIIDYSKDIY 100
    SVGVTGKIIK KINLPDGGYN IFVSTFDRIK FVKVVLNDKF PIIEIDYLKQ 150
    IPVRKDDIQS KAVYGSILLR TKEIFAHRKM PEVQLNMVNI EDKGKLCDIV 200
    ASTISSSKND HQIVLETLNV KDRLKKVLEL IYEELNLIEI QNKIAKGIQE 250
    RLEKQQKEFF LKEQLKAIKA ELGIGDKKSS DLEKLKTKLK ALELKGEPLE 300
    VVEKELEKFS LLETSSAEYI VVRNYLELIT ELPWRDFKIN FDKLDLQKSK 350
    KILDKTHYGM NEVKDRIIEY ISVLKLRKTQ KGAIILLVGP PGVGKTSIGA 400
    AIAKVLRTKF FRFSVGGMRD ESEIKGHRRT YVGALPGKII QGLRITKTNS 450
    PVFLIDEVDK ISASSYGDPF SVLLEVLDPE QNVRFRDHYL DLPFDISNVF 500
    FILTANSVET IPRPLLNRME IIEISGYIDN EKIEIARKYL IPKVLSENGV 550
    DKDSLKFQSS SLVQIAQEYA RDNGVRNFEK YLNKIVRKVA RKLIENTEVK 600
    SYQISNDNLE EYVGVPVFRK ESMPNAMYSG MVMGLAWTNY GGSTLMIETV 650
    KTESKVGGIK LTGRLGDVMK ESANIAYTYV NSIKGDLSIS KSFFEKNIIH 700
    LHIPEGATPK DGPSAGITIA SAFISLALNK VVRPHLAMTG ELSLTGNVMM 750
    IGGLKEKIIA AKRSGVEHII VPKANRVDLE EIPTNIKSGI NFYLVDNMRE 800
    VIKLLF 806
    Length:806
    Mass (Da):90,710
    Last modified:November 1, 1997 - v1
    Checksum:i71F488D719B1424E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77216 Genomic DNA. Translation: AAB72011.1.
    AE000783 Genomic DNA. Translation: AAB91493.1.
    PIRiE70131.
    RefSeqiNP_212387.1. NC_001318.1.
    WP_002656104.1. NC_001318.1.

    Genome annotation databases

    EnsemblBacteriaiAAB91493; AAB91493; BB_0253.
    GeneIDi1195090.
    KEGGibbu:BB_0253.
    PATRICi20557124. VBIBorBur75917_0652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77216 Genomic DNA. Translation: AAB72011.1 .
    AE000783 Genomic DNA. Translation: AAB91493.1 .
    PIRi E70131.
    RefSeqi NP_212387.1. NC_001318.1.
    WP_002656104.1. NC_001318.1.

    3D structure databases

    ProteinModelPortali Q59185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224326.BB0253.

    Proteomic databases

    PRIDEi Q59185.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB91493 ; AAB91493 ; BB_0253 .
    GeneIDi 1195090.
    KEGGi bbu:BB_0253.
    PATRICi 20557124. VBIBorBur75917_0652.

    Phylogenomic databases

    eggNOGi COG0466.
    KOi K01338.
    OMAi DSLKFQS.
    OrthoDBi EOG6XHC23.

    Enzyme and pathway databases

    BioCyci BBUR224326:G9SO-253-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_01973. lon_bact.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR027543. Lon_bac.
    IPR004815. Lon_bac/euk-typ.
    IPR027065. Lon_Prtase.
    IPR027417. P-loop_NTPase.
    IPR008269. Pept_S16_C.
    IPR003111. Pept_S16_N.
    IPR008268. Peptidase_S16_AS.
    IPR015947. PUA-like_domain.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR10046. PTHR10046. 1 hit.
    Pfami PF00004. AAA. 1 hit.
    PF02190. LON. 1 hit.
    PF05362. Lon_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001174. Lon_proteas. 1 hit.
    SMARTi SM00382. AAA. 1 hit.
    SM00464. LON. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsi TIGR00763. lon. 1 hit.
    PROSITEi PS01046. LON_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the Borrelia burgdorferi lon gene."
      Cloud J.L., Marconi R.T., Eggers C.H., Garon C.F., Tilly K., Samuels D.S.
      Gene 194:137-141(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

    Entry informationi

    Entry nameiLON1_BORBU
    AccessioniPrimary (citable) accession number: Q59185
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3