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Protein

Lon protease 1

Gene

lon1

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei714 – 7141UniRule annotation
Active sitei757 – 7571UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi389 – 3968ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. ATP-dependent peptidase activity Source: UniProtKB-HAMAP
  3. sequence-specific DNA binding Source: UniProtKB-HAMAP
  4. serine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular response to stress Source: UniProtKB-HAMAP
  2. misfolded or incompletely synthesized protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-253-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease 1UniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease La 1UniRule annotation
Gene namesi
Name:lon1UniRule annotation
Ordered Locus Names:BB_0253
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Lon protease 1PRO_0000076118Add
BLAST

Proteomic databases

PRIDEiQ59185.

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi224326.BB0253.

Structurei

3D structure databases

ProteinModelPortaliQ59185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 231201LonUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation
Contains 1 Lon domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0466.
KOiK01338.
OMAiGSTLMIE.
OrthoDBiEOG6XHC23.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDESKKARSG DKKKEKAVAG ILPHSNKPAR VPLIAVPSHP VFPGMFIPIV
60 70 80 90 100
LISDSDMKAI DYAMKGNGII ALFVLNDKFL EKNNNNAQQK LIIDYSKDIY
110 120 130 140 150
SVGVTGKIIK KINLPDGGYN IFVSTFDRIK FVKVVLNDKF PIIEIDYLKQ
160 170 180 190 200
IPVRKDDIQS KAVYGSILLR TKEIFAHRKM PEVQLNMVNI EDKGKLCDIV
210 220 230 240 250
ASTISSSKND HQIVLETLNV KDRLKKVLEL IYEELNLIEI QNKIAKGIQE
260 270 280 290 300
RLEKQQKEFF LKEQLKAIKA ELGIGDKKSS DLEKLKTKLK ALELKGEPLE
310 320 330 340 350
VVEKELEKFS LLETSSAEYI VVRNYLELIT ELPWRDFKIN FDKLDLQKSK
360 370 380 390 400
KILDKTHYGM NEVKDRIIEY ISVLKLRKTQ KGAIILLVGP PGVGKTSIGA
410 420 430 440 450
AIAKVLRTKF FRFSVGGMRD ESEIKGHRRT YVGALPGKII QGLRITKTNS
460 470 480 490 500
PVFLIDEVDK ISASSYGDPF SVLLEVLDPE QNVRFRDHYL DLPFDISNVF
510 520 530 540 550
FILTANSVET IPRPLLNRME IIEISGYIDN EKIEIARKYL IPKVLSENGV
560 570 580 590 600
DKDSLKFQSS SLVQIAQEYA RDNGVRNFEK YLNKIVRKVA RKLIENTEVK
610 620 630 640 650
SYQISNDNLE EYVGVPVFRK ESMPNAMYSG MVMGLAWTNY GGSTLMIETV
660 670 680 690 700
KTESKVGGIK LTGRLGDVMK ESANIAYTYV NSIKGDLSIS KSFFEKNIIH
710 720 730 740 750
LHIPEGATPK DGPSAGITIA SAFISLALNK VVRPHLAMTG ELSLTGNVMM
760 770 780 790 800
IGGLKEKIIA AKRSGVEHII VPKANRVDLE EIPTNIKSGI NFYLVDNMRE

VIKLLF
Length:806
Mass (Da):90,710
Last modified:November 1, 1997 - v1
Checksum:i71F488D719B1424E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77216 Genomic DNA. Translation: AAB72011.1.
AE000783 Genomic DNA. Translation: AAB91493.1.
PIRiE70131.
RefSeqiNP_212387.1. NC_001318.1.
WP_002656104.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAB91493; AAB91493; BB_0253.
GeneIDi1195090.
KEGGibbu:BB_0253.
PATRICi20557124. VBIBorBur75917_0652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77216 Genomic DNA. Translation: AAB72011.1.
AE000783 Genomic DNA. Translation: AAB91493.1.
PIRiE70131.
RefSeqiNP_212387.1. NC_001318.1.
WP_002656104.1. NC_001318.1.

3D structure databases

ProteinModelPortaliQ59185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB0253.

Proteomic databases

PRIDEiQ59185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB91493; AAB91493; BB_0253.
GeneIDi1195090.
KEGGibbu:BB_0253.
PATRICi20557124. VBIBorBur75917_0652.

Phylogenomic databases

eggNOGiCOG0466.
KOiK01338.
OMAiGSTLMIE.
OrthoDBiEOG6XHC23.

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-253-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of the Borrelia burgdorferi lon gene."
    Cloud J.L., Marconi R.T., Eggers C.H., Garon C.F., Tilly K., Samuels D.S.
    Gene 194:137-141(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiLON1_BORBU
AccessioniPrimary (citable) accession number: Q59185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.