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Q59185

- LON1_BORBU

UniProt

Q59185 - LON1_BORBU

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Protein

Lon protease 1

Gene
lon1, BB_0253
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei714 – 7141 By similarity
Active sitei757 – 7571 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi389 – 3968ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. ATP-dependent peptidase activity Source: UniProtKB-HAMAP
  3. sequence-specific DNA binding Source: UniProtKB-HAMAP
  4. serine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular response to stress Source: UniProtKB-HAMAP
  2. misfolded or incompletely synthesized protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-253-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease 1 (EC:3.4.21.53)
Alternative name(s):
ATP-dependent protease La 1
Gene namesi
Name:lon1
Ordered Locus Names:BB_0253
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Lon protease 1UniRule annotationPRO_0000076118Add
BLAST

Proteomic databases

PRIDEiQ59185.

Expressioni

Inductioni

By heat shock By similarity.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity By similarity.

Protein-protein interaction databases

STRINGi224326.BB0253.

Structurei

3D structure databases

ProteinModelPortaliQ59185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 231201LonAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S16 family.
Contains 1 Lon domain.

Phylogenomic databases

eggNOGiCOG0466.
KOiK01338.
OMAiDSLKFQS.
OrthoDBiEOG6XHC23.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59185-1 [UniParc]FASTAAdd to Basket

« Hide

MDESKKARSG DKKKEKAVAG ILPHSNKPAR VPLIAVPSHP VFPGMFIPIV    50
LISDSDMKAI DYAMKGNGII ALFVLNDKFL EKNNNNAQQK LIIDYSKDIY 100
SVGVTGKIIK KINLPDGGYN IFVSTFDRIK FVKVVLNDKF PIIEIDYLKQ 150
IPVRKDDIQS KAVYGSILLR TKEIFAHRKM PEVQLNMVNI EDKGKLCDIV 200
ASTISSSKND HQIVLETLNV KDRLKKVLEL IYEELNLIEI QNKIAKGIQE 250
RLEKQQKEFF LKEQLKAIKA ELGIGDKKSS DLEKLKTKLK ALELKGEPLE 300
VVEKELEKFS LLETSSAEYI VVRNYLELIT ELPWRDFKIN FDKLDLQKSK 350
KILDKTHYGM NEVKDRIIEY ISVLKLRKTQ KGAIILLVGP PGVGKTSIGA 400
AIAKVLRTKF FRFSVGGMRD ESEIKGHRRT YVGALPGKII QGLRITKTNS 450
PVFLIDEVDK ISASSYGDPF SVLLEVLDPE QNVRFRDHYL DLPFDISNVF 500
FILTANSVET IPRPLLNRME IIEISGYIDN EKIEIARKYL IPKVLSENGV 550
DKDSLKFQSS SLVQIAQEYA RDNGVRNFEK YLNKIVRKVA RKLIENTEVK 600
SYQISNDNLE EYVGVPVFRK ESMPNAMYSG MVMGLAWTNY GGSTLMIETV 650
KTESKVGGIK LTGRLGDVMK ESANIAYTYV NSIKGDLSIS KSFFEKNIIH 700
LHIPEGATPK DGPSAGITIA SAFISLALNK VVRPHLAMTG ELSLTGNVMM 750
IGGLKEKIIA AKRSGVEHII VPKANRVDLE EIPTNIKSGI NFYLVDNMRE 800
VIKLLF 806
Length:806
Mass (Da):90,710
Last modified:November 1, 1997 - v1
Checksum:i71F488D719B1424E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77216 Genomic DNA. Translation: AAB72011.1.
AE000783 Genomic DNA. Translation: AAB91493.1.
PIRiE70131.
RefSeqiNP_212387.1. NC_001318.1.
WP_002656104.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAB91493; AAB91493; BB_0253.
GeneIDi1195090.
KEGGibbu:BB_0253.
PATRICi20557124. VBIBorBur75917_0652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77216 Genomic DNA. Translation: AAB72011.1 .
AE000783 Genomic DNA. Translation: AAB91493.1 .
PIRi E70131.
RefSeqi NP_212387.1. NC_001318.1.
WP_002656104.1. NC_001318.1.

3D structure databases

ProteinModelPortali Q59185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224326.BB0253.

Proteomic databases

PRIDEi Q59185.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB91493 ; AAB91493 ; BB_0253 .
GeneIDi 1195090.
KEGGi bbu:BB_0253.
PATRICi 20557124. VBIBorBur75917_0652.

Phylogenomic databases

eggNOGi COG0466.
KOi K01338.
OMAi DSLKFQS.
OrthoDBi EOG6XHC23.

Enzyme and pathway databases

BioCyci BBUR224326:G9SO-253-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01973. lon_bact.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
PANTHERi PTHR10046. PTHR10046. 1 hit.
Pfami PF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF001174. Lon_proteas. 1 hit.
SMARTi SM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsi TIGR00763. lon. 1 hit.
PROSITEi PS01046. LON_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of the Borrelia burgdorferi lon gene."
    Cloud J.L., Marconi R.T., Eggers C.H., Garon C.F., Tilly K., Samuels D.S.
    Gene 194:137-141(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiLON1_BORBU
AccessioniPrimary (citable) accession number: Q59185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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