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Protein

Lon protease 1

Gene

lon1

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei714UniRule annotation1
Active sitei757UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi389 – 396ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.4.21.53 902

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease 1UniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease La 1UniRule annotation
Gene namesi
Name:lon1UniRule annotation
Ordered Locus Names:BB_0253
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000001807 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761181 – 806Lon protease 1Add BLAST806

Proteomic databases

PRIDEiQ59185

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi224326.BB_0253

Structurei

3D structure databases

ProteinModelPortaliQ59185
SMRiQ59185
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 233Lon N-terminalPROSITE-ProRule annotationAdd BLAST203
Domaini626 – 806Lon proteolyticPROSITE-ProRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6P Bacteria
COG0466 LUCA
KOiK01338
OMAiGTILCFY

Family and domain databases

Gene3Di3.30.230.10, 1 hit
HAMAPiMF_01973 lon_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027543 Lon_bac
IPR004815 Lon_bac/euk-typ
IPR008269 Lon_proteolytic
IPR027065 Lon_Prtase
IPR003111 Lon_substr-bd
IPR027417 P-loop_NTPase
IPR008268 Peptidase_S16_AS
IPR015947 PUA-like_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR43718 PTHR43718, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF05362 Lon_C, 1 hit
PF02190 LON_substr_bdg, 1 hit
PIRSFiPIRSF001174 Lon_proteas, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00464 LON, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00763 lon, 1 hit
PROSITEiView protein in PROSITE
PS51787 LON_N, 1 hit
PS51786 LON_PROTEOLYTIC, 1 hit
PS01046 LON_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q59185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDESKKARSG DKKKEKAVAG ILPHSNKPAR VPLIAVPSHP VFPGMFIPIV
60 70 80 90 100
LISDSDMKAI DYAMKGNGII ALFVLNDKFL EKNNNNAQQK LIIDYSKDIY
110 120 130 140 150
SVGVTGKIIK KINLPDGGYN IFVSTFDRIK FVKVVLNDKF PIIEIDYLKQ
160 170 180 190 200
IPVRKDDIQS KAVYGSILLR TKEIFAHRKM PEVQLNMVNI EDKGKLCDIV
210 220 230 240 250
ASTISSSKND HQIVLETLNV KDRLKKVLEL IYEELNLIEI QNKIAKGIQE
260 270 280 290 300
RLEKQQKEFF LKEQLKAIKA ELGIGDKKSS DLEKLKTKLK ALELKGEPLE
310 320 330 340 350
VVEKELEKFS LLETSSAEYI VVRNYLELIT ELPWRDFKIN FDKLDLQKSK
360 370 380 390 400
KILDKTHYGM NEVKDRIIEY ISVLKLRKTQ KGAIILLVGP PGVGKTSIGA
410 420 430 440 450
AIAKVLRTKF FRFSVGGMRD ESEIKGHRRT YVGALPGKII QGLRITKTNS
460 470 480 490 500
PVFLIDEVDK ISASSYGDPF SVLLEVLDPE QNVRFRDHYL DLPFDISNVF
510 520 530 540 550
FILTANSVET IPRPLLNRME IIEISGYIDN EKIEIARKYL IPKVLSENGV
560 570 580 590 600
DKDSLKFQSS SLVQIAQEYA RDNGVRNFEK YLNKIVRKVA RKLIENTEVK
610 620 630 640 650
SYQISNDNLE EYVGVPVFRK ESMPNAMYSG MVMGLAWTNY GGSTLMIETV
660 670 680 690 700
KTESKVGGIK LTGRLGDVMK ESANIAYTYV NSIKGDLSIS KSFFEKNIIH
710 720 730 740 750
LHIPEGATPK DGPSAGITIA SAFISLALNK VVRPHLAMTG ELSLTGNVMM
760 770 780 790 800
IGGLKEKIIA AKRSGVEHII VPKANRVDLE EIPTNIKSGI NFYLVDNMRE

VIKLLF
Length:806
Mass (Da):90,710
Last modified:November 1, 1997 - v1
Checksum:i71F488D719B1424E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77216 Genomic DNA Translation: AAB72011.1
AE000783 Genomic DNA Translation: AAB91493.1
PIRiE70131
RefSeqiNP_212387.1, NC_001318.1
WP_002656104.1, NC_001318.1

Genome annotation databases

EnsemblBacteriaiAAB91493; AAB91493; BB_0253
GeneIDi1195090
KEGGibbu:BB_0253
PATRICifig|224326.49.peg.652

Similar proteinsi

Entry informationi

Entry nameiLON1_BORBU
AccessioniPrimary (citable) accession number: Q59185
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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