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Q59181

- PGK_BORBU

UniProt

Q59181 - PGK_BORBU

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371SubstrateBy similarity
    Binding sitei119 – 1191SubstrateBy similarity
    Binding sitei152 – 1521SubstrateBy similarity
    Binding sitei202 – 2021ATPBy similarity
    Binding sitei293 – 2931ATP; via carbonyl oxygenBy similarity
    Binding sitei324 – 3241ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi350 – 3534ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBBUR224326:G9SO-55-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:pgk
    Ordered Locus Names:BB_0056
    OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    Taxonomic identifieri224326 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001807: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Phosphoglycerate kinasePRO_0000145911Add
    BLAST

    Proteomic databases

    PRIDEiQ59181.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi224326.BB0056.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59181.
    SMRiQ59181. Positions 1-393.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni22 – 243Substrate bindingBy similarity
    Regioni60 – 634Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    KOiK00927.
    OMAiAGHPVGK.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59181-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIKTVKDFS SFAGKRALVR CDFNVPLKEG SISDDTRIRA ALSTIEYLKE    50
    RGARIVLVSH LGRPDGKKNP KYSLKPVANR LSELLGQDVK MLSDCIGSEV 100
    VNSTLQMKDG DVVLLENVRF YAEEEKNDKN FAKKLSENGD VFVNDAFGAA 150
    HRAHASTVGV ADYLPSVGGF LMEKEDKFLG GILKNPERPF VSIIGGSKVS 200
    SKIAVLESLL SKSNVVVIGG GMAYTFLHSE GYSIGKSLLE DEYIGIASSF 250
    LKKAKELGVK VILPLDHIVA DDFNKNSIPE YIDSFNIPEN KIGMDIGANT 300
    LKEIENVVKT AKTIIWNGPL GVFEFDSFSK GTAKVAEMVA SCSGLTVVGG 350
    GDSVAAVNKF NLSDKITHVS TGGGASLEYL EGRILPGIKV LEN 393
    Length:393
    Mass (Da):42,346
    Last modified:December 15, 1998 - v2
    Checksum:iEB437EFD5F7AFFDE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti164 – 1641L → S in AAB53931. (PubMed:8557349)Curated
    Sequence conflicti177 – 1782KF → NS in AAB53931. (PubMed:8557349)Curated
    Sequence conflicti190 – 1901F → S in AAB53931. (PubMed:8557349)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28760 Genomic DNA. Translation: AAB53931.1.
    AE000783 Genomic DNA. Translation: AAC66451.1.
    L32595 Genomic DNA. Translation: AAC41405.1.
    PIRiH70106.
    RefSeqiNP_212190.1. NC_001318.1.

    Genome annotation databases

    EnsemblBacteriaiAAC66451; AAC66451; BB_0056.
    GeneIDi1194892.
    KEGGibbu:BB_0056.
    PATRICi20556717. VBIBorBur75917_0454.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28760 Genomic DNA. Translation: AAB53931.1 .
    AE000783 Genomic DNA. Translation: AAC66451.1 .
    L32595 Genomic DNA. Translation: AAC41405.1 .
    PIRi H70106.
    RefSeqi NP_212190.1. NC_001318.1.

    3D structure databases

    ProteinModelPortali Q59181.
    SMRi Q59181. Positions 1-393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224326.BB0056.

    Proteomic databases

    PRIDEi Q59181.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC66451 ; AAC66451 ; BB_0056 .
    GeneIDi 1194892.
    KEGGi bbu:BB_0056.
    PATRICi 20556717. VBIBorBur75917_0454.

    Phylogenomic databases

    eggNOGi COG0126.
    KOi K00927.
    OMAi AGHPVGK.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci BBUR224326:G9SO-55-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A glyceraldehyde-3-phosphate dehydrogenase homolog in Borrelia burgdorferi and Borrelia hermsii."
      Anda P., Gebbia J.A., Backenson P.B., Coleman J.L., Benach J.L.
      Infect. Immun. 64:262-268(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
    3. "Conservation of gene arrangement and an unusual organization of rRNA genes in the linear chromosomes of the Lyme disease spirochaetes Borrelia burgdorferi, B. garinii and B. afzelii."
      Ojaimi C., Davidson B.E., Saint-Girons I., Old I.G.
      Microbiology 140:2931-2940(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 346-393.
      Strain: 212.

    Entry informationi

    Entry nameiPGK_BORBU
    AccessioniPrimary (citable) accession number: Q59181
    Secondary accession number(s): Q59186
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3