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Q59179

- TPIS_BUCAP

UniProt

Q59179 - TPIS_BUCAP

Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91SubstrateUniRule annotation
    Binding sitei11 – 111SubstrateUniRule annotation
    Active sitei96 – 961ElectrophileUniRule annotation
    Active sitei168 – 1681Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. triose-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP
    3. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis, Pentose shunt

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-311-MONOMER.
    UniPathwayiUPA00109; UER00189.
    UPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
    Short name:
    TIMUniRule annotation
    Alternative name(s):
    Triose-phosphate isomeraseUniRule annotation
    Gene namesi
    Name:tpiAUniRule annotation
    Synonyms:tpi
    Ordered Locus Names:BUsg_297
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Triosephosphate isomerasePRO_0000090196Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198804.BUsg297.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the triosephosphate isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0149.
    KOiK01803.
    OMAiPAIYLDQ.
    OrthoDBiEOG66QM23.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00147_B. TIM_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR022896. TrioseP_Isoase_bac/euk.
    IPR000652. Triosephosphate_isomerase.
    IPR020861. Triosephosphate_isomerase_AS.
    [Graphical view]
    PANTHERiPTHR21139. PTHR21139. 1 hit.
    PfamiPF00121. TIM. 1 hit.
    [Graphical view]
    SUPFAMiSSF51351. SSF51351. 1 hit.
    TIGRFAMsiTIGR00419. tim. 1 hit.
    PROSITEiPS00171. TIM_1. 1 hit.
    PS51440. TIM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59179-1 [UniParc]FASTAAdd to Basket

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    MKKKIIAANW KLNGSIKTIS YFLTFLKSQI SSFLKNNIII IAPPTVFLER    50
    VYKDINSINI HLAAQNIDVN LTGAFTGENS ALMMKDIGVK YIIIGHSERR 100
    LLHNENNEII AKKFCLVKNL NLVPILCIGE TEAEKKSNKT EKILKEQLNS 150
    IFNSFGEKAF RNAVIAYEPI WSIGTGVSAD PKNVQLIHKF IKNYIKKYDI 200
    VSAENLIVQY GGSVTSLNAG NFLKQPDIDG LLIGSASLKH EEFLKIIKIS 250
    DSFL 254
    Length:254
    Mass (Da):28,458
    Last modified:November 1, 1997 - v1
    Checksum:iDFA12B60F9E68E10
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43549 Genomic DNA. Translation: AAC05431.1.
    AE013218 Genomic DNA. Translation: AAM67852.1.
    RefSeqiNP_660641.1. NC_004061.1.
    WP_011053819.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67852; AAM67852; BUsg_297.
    GeneIDi1005501.
    KEGGibas:BUsg297.
    PATRICi21247403. VBIBucAph100086_0311.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43549 Genomic DNA. Translation: AAC05431.1 .
    AE013218 Genomic DNA. Translation: AAM67852.1 .
    RefSeqi NP_660641.1. NC_004061.1.
    WP_011053819.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q59179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg297.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67852 ; AAM67852 ; BUsg_297 .
    GeneIDi 1005501.
    KEGGi bas:BUsg297.
    PATRICi 21247403. VBIBucAph100086_0311.

    Phylogenomic databases

    eggNOGi COG0149.
    KOi K01803.
    OMAi PAIYLDQ.
    OrthoDBi EOG66QM23.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00189 .
    UPA00138 .
    BioCyci BAPH198804:GHMG-311-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00147_B. TIM_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR022896. TrioseP_Isoase_bac/euk.
    IPR000652. Triosephosphate_isomerase.
    IPR020861. Triosephosphate_isomerase_AS.
    [Graphical view ]
    PANTHERi PTHR21139. PTHR21139. 1 hit.
    Pfami PF00121. TIM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51351. SSF51351. 1 hit.
    TIGRFAMsi TIGR00419. tim. 1 hit.
    PROSITEi PS00171. TIM_1. 1 hit.
    PS51440. TIM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a DNA fragment from Buchnera aphidicola (Aphid endosymbiont) containing the genes aspS-trxB-serS-serC-aroA-rpsA-himD-tpiA."
      Thao M.L., Baumann P.
      Curr. Microbiol. 35:68-69(1997)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiTPIS_BUCAP
    AccessioniPrimary (citable) accession number: Q59179
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3