Reviewed, UniProtKB/Swiss-Prot Q59178 (AROA_BUCAP)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	BUsg_301

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_0000088236

Sequences

	Sequence		Length	Mass (Da)
	Q59178-1 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: 90683C362EAA92D3	FASTA	428	47,030
	10 20 30 40 50 60 MQKFLELKPV SYINGTIYLP GSKSISNRVL LLSAMANGIT CLTNLLDSQD TQYMLNALRK 70 80 90 100 110 120 IGIKFFLSNN NTTCHVHGIG KAFHLSHPIS LFLGNAGTAM RPLLAALSLY ENNVVLSGDD 130 140 150 160 170 180 RMHERPIAHL VDALKQGGAT LEYKKGIGYP PVLTKGGFKG GSIMLDGSIS SQFLTSLLMV 190 200 210 220 230 240 APLALQNTNI FIKGNLVSKP YIDITLNLMK SFGVNIVNDC YKSFYIKGNQ KYESPGNYLV 250 260 270 280 290 300 EGDASSASYF LAAAAIKGGS VKVVGVGKKS VQGDIKFADV LEKMGAIIDW GDSFIVCRHN 310 320 330 340 350 360 KLEKIDLDMN HIPDAAMTIA IVALFAKGTS IIKNIYNWRV KETDRLSAMS KELKKVGAII 370 380 390 400 410 420 KEGRDCLSIT PPNFFKFAEI DTYNDHRMAM CFSLICLSGI SVRILNPNCI SKTFPSYFEN FLKISRFD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ribosomal protein S1 (RpsA) of Buchnera aphidicola, the endosymbiont of aphids: characterization of the gene and detection of the product." Clark M.A., Baumann L., Baumann P., Rouhbakhsh D. Curr. Microbiol. 32:89-94(1996) [PubMed: 8574133] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L43549 Genomic DNA. Translation: AAC05428.1. AE013218 Genomic DNA. Translation: AAM67855.1.
RefSeq	NP_660644.1.
3D structure databases
HSSP	HSSP built from PDB template 1G6S based on UniProtKB P07638.
ModBase	Search...
Genome annotation databases
GeneID	1005505.
GenomeReviews	Gene locus BUsg_301 in contig AE013218_GR.
KEGG	bas:BUsg301.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q59178.
OMA	EIDTYND.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG301-MON.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BUCAP

Accession

Primary (citable) accession number: Q59178

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 15, 1998
Last modified:	November 3, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)