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Q59167

- ACSA2_KOMHA

UniProt

Q59167 - ACSA2_KOMHA

Protein

Cellulose synthase 2

Gene

acsAII

Organism
Komagataeibacter hansenii (Gluconacetobacter hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei187 – 1871Sequence Analysis
    Binding sitei234 – 2341SubstrateSequence Analysis
    Binding sitei236 – 2361SubstrateSequence Analysis
    Active sitei331 – 3311Sequence Analysis

    GO - Molecular functioni

    1. cellulose synthase (UDP-forming) activity Source: UniProtKB-EC
    2. cyclic-di-GMP binding Source: InterPro

    GO - Biological processi

    1. cellulose biosynthetic process Source: UniProtKB-KW
    2. UDP-glucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Cellulose biosynthesis

    Protein family/group databases

    CAZyiGT2. Glycosyltransferase Family 2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cellulose synthase 2
    Including the following 2 domains:
    Cellulose synthase catalytic subunit [UDP-forming] (EC:2.4.1.12)
    Cyclic di-GMP-binding domain
    Alternative name(s):
    Cellulose synthase 2 regulatory domain
    Gene namesi
    Name:acsAII
    OrganismiKomagataeibacter hansenii (Gluconacetobacter hansenii)
    Taxonomic identifieri436 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeKomagataeibacter

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15961596Cellulose synthase 2PRO_0000059261Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ59167.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei421 – 44121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei505 – 52521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei544 – 56421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1553 – 157321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini570 – 669100PilZAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 749749CatalyticAdd
    BLAST
    Regioni145 – 23894Catalytic subdomain AAdd
    BLAST
    Regioni315 – 37561Catalytic subdomain BAdd
    BLAST
    Regioni750 – 1596847Cyclic di-GMP bindingSequence AnalysisAdd
    BLAST

    Domaini

    There are two conserved domains in the globular part of the catalytic subunit: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site.

    Sequence similaritiesi

    In the N-terminal section; belongs to the glycosyltransferase 2 family.Curated
    In the C-terminal section; belongs to the AcsB/BcsB family.Curated
    Contains 1 PilZ domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR003919. Cell_synth_A.
    IPR003920. Cell_synth_B.
    IPR018513. Cell_synthase_bac.
    IPR005150. Cellulose_synth.
    IPR001173. Glyco_trans_2-like.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR009875. PilZ_domain.
    [Graphical view]
    PfamiPF03170. BcsB. 1 hit.
    PF03552. Cellulose_synt. 1 hit.
    PF00535. Glycos_transf_2. 1 hit.
    PF07238. PilZ. 1 hit.
    [Graphical view]
    PRINTSiPR01440. CELLSNTHASEB.
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR03030. CelA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59167-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIYRAILKRL RLEQLARVPA VSAASPFVMM AVGVFLMLMA GGVTISTTSQ     50
    AFVTCGTVGL FLLLKGRKGR GVTCFLMMLS LLVSLRYMVW RLTTTLELHS 100
    PLQAALSLLL VAAELYALLT LCLSYFQMSW PLDRKPLPLP ADTTDWPVVD 150
    VYVPSYNEEL SLVRSTVLGA LAIDWPADKL NVYILDDGRR KSFHAFAMEA 200
    GAGYIIRDQN NHAKAGNLNH ALRVTEGEYV VIFDCDHIPT RGFLKKTIGW 250
    MMADPKLALL QTPHHFYSPD PFQRNLATGQ NVPPEGNMFY GLVQDGNDFW 300
    DATFFCGSCA AIRRSAVLGI GGFATETVTE DAHTALKMQR EGWHTAYLRQ 350
    PLAAGLSTER LMLHIGQRVR WARGMLQIMR LDNPLLGSGL RWQQRLCYLS 400
    AMSHFLFAIP RLVFLASPLA FLFLGQNIIA ASPFAILVYA FPHVFHSIGT 450
    LSRVEGRWRY SFWSEIYETT LALFLVRVTI MTLLNPRKGE FNVTDKGGLL 500
    QSEYFDLNAV YPNVILAVIL ALALVRGIGG MMWEYHDRLA LQSFALNTLW 550
    VAVSLIIVLA SIAVGRETRQ IRHKPRVRAT LPITLIDEHG QHYHAHTSDI 600
    SLGGIAARLS TEHALPTQTR VTMLYHNEKD GIDVRIPAVI LFSKPGQLHL 650
    QWSVDDLDVE RQIVEFMFGR NDAWSNWGDF QPDRPVRSFL MVLRSIGGLF 700
    RRGQRLFRWQ APQEAPLAES EHVEEEKLEK KSLVLKPVRR SARHGATASL 750
    IVLLGLPAAI APSLAQAPSR ATPVATEQGA TPVEPPPVNA PPPPSLPQPP 800
    GTLPTPPQIA PASAGELLPA ATAVSLPTGP ATQQMRERLS ERTGVSPASP 850
    FGDTNTGALP ADPSAPPIDP ADAARVADGE ITRTSTFRDL GLATGPLTLR 900
    GFSPLQGLDV IVPANRVVTR ARITLSGALS PSLLPEASAV SVTLNEQYVG 950
    TIRVDPEHPR FGPITFDIDP LYFTGDNKLN FHFAGEYRRD CNDLYNEVLW 1000
    ARISDFSTVT LTTTRIAPDR KLSYLPAPFY DPNLRTPLRV PVVMPNPDAH 1050
    GMLKASALVA SWFGKLADFR KVSFPVSTTI PASGNAIAIG ENLPIDARGT 1100
    RPTGPTLSEV ENPNDRLGTI LVLTGRNAQE VEVAARVLAF SSDTLGAVGT 1150
    KVVNDVTLQP RHPYDAPAFV PTDRPVRFGE LVAASDLQGG GFAPPVMALP 1200
    FHLPPDLYSW RNRPYPIDLW VRTPGGPVVD LETSRLDVHL NNNYLDSFTL 1250
    KPPSLWAAWS ERLVNQHAGA VEHAAALPPW LLFGQNQLKF SFDARPIDRG 1300
    VCRRTPDDIH MSVDSDSWLD FRRGYHFARL PNLSYFAEAA FPFSRMADLS 1350
    ETTVVVPHHI DAGTAGTFMD LMGFFGATTW YPASGVQVAD INDLSEHPPQ 1400
    GDILILATAG DAPKFEELLT RAPYELTDGH IRVGQHMGLQ GIWYLFQDHD 1450
    HAGLQDGVQA NLNAPIAGAG VLLGAQSPYR SDRSVVALMG DTPSRMHDLV 1500
    MGLRSKEDVP RIQGDLVLRN GDRLTSYRTA PTFTMGSLPW WMWLDWYLGT 1550
    RPLTLYVLGL VGAGLVAAAA VRLLRRRAQH RLEEAARVKD TTDASH 1596
    Length:1,596
    Mass (Da):175,801
    Last modified:November 1, 1996 - v1
    Checksum:iD98A6F6259E1F3CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15957 Genomic DNA. Translation: AAA85264.1.
    PIRiT31338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15957 Genomic DNA. Translation: AAA85264.1 .
    PIRi T31338.

    3D structure databases

    ProteinModelPortali Q59167.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT2. Glycosyltransferase Family 2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR003919. Cell_synth_A.
    IPR003920. Cell_synth_B.
    IPR018513. Cell_synthase_bac.
    IPR005150. Cellulose_synth.
    IPR001173. Glyco_trans_2-like.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR009875. PilZ_domain.
    [Graphical view ]
    Pfami PF03170. BcsB. 1 hit.
    PF03552. Cellulose_synt. 1 hit.
    PF00535. Glycos_transf_2. 1 hit.
    PF07238. PilZ. 1 hit.
    [Graphical view ]
    PRINTSi PR01440. CELLSNTHASEB.
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR03030. CelA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a second cellulose synthase gene (acsAII) in Acetobacter xylinum."
      Saxena I.M., Brown R.M. Jr.
      J. Bacteriol. 177:5276-5283(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 23769 / NCIMB 8246.

    Entry informationi

    Entry nameiACSA2_KOMHA
    AccessioniPrimary (citable) accession number: Q59167
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    It is not essential for cellulose production in this strain.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3