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Q59167

- ACSA2_KOMHA

UniProt

Q59167 - ACSA2_KOMHA

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Protein

Cellulose synthase 2

Gene

acsAII

Organism
Komagataeibacter hansenii (Gluconacetobacter hansenii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei187 – 1871Sequence Analysis
Binding sitei234 – 2341SubstrateSequence Analysis
Binding sitei236 – 2361SubstrateSequence Analysis
Active sitei331 – 3311Sequence Analysis

GO - Molecular functioni

  1. cellulose synthase (UDP-forming) activity Source: UniProtKB-EC
  2. cyclic-di-GMP binding Source: InterPro

GO - Biological processi

  1. cellulose biosynthetic process Source: UniProtKB-KW
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cellulose biosynthesis

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Cellulose synthase 2
Including the following 2 domains:
Cellulose synthase catalytic subunit [UDP-forming] (EC:2.4.1.12)
Cyclic di-GMP-binding domain
Alternative name(s):
Cellulose synthase 2 regulatory domain
Gene namesi
Name:acsAII
OrganismiKomagataeibacter hansenii (Gluconacetobacter hansenii)
Taxonomic identifieri436 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeKomagataeibacter

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence AnalysisAdd
BLAST
Transmembranei421 – 44121HelicalSequence AnalysisAdd
BLAST
Transmembranei505 – 52521HelicalSequence AnalysisAdd
BLAST
Transmembranei544 – 56421HelicalSequence AnalysisAdd
BLAST
Transmembranei1553 – 157321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15961596Cellulose synthase 2PRO_0000059261Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ59167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini570 – 669100PilZAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 749749CatalyticAdd
BLAST
Regioni145 – 23894Catalytic subdomain AAdd
BLAST
Regioni315 – 37561Catalytic subdomain BAdd
BLAST
Regioni750 – 1596847Cyclic di-GMP bindingSequence AnalysisAdd
BLAST

Domaini

There are two conserved domains in the globular part of the catalytic subunit: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site.

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 2 family.Curated
In the C-terminal section; belongs to the AcsB/BcsB family.Curated
Contains 1 PilZ domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003919. Cell_synth_A.
IPR003920. Cell_synth_B.
IPR018513. Cell_synthase_bac.
IPR005150. Cellulose_synth.
IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR009875. PilZ_domain.
[Graphical view]
PfamiPF03170. BcsB. 1 hit.
PF03552. Cellulose_synt. 1 hit.
PF00535. Glycos_transf_2. 1 hit.
PF07238. PilZ. 1 hit.
[Graphical view]
PRINTSiPR01440. CELLSNTHASEB.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03030. CelA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59167-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIYRAILKRL RLEQLARVPA VSAASPFVMM AVGVFLMLMA GGVTISTTSQ
60 70 80 90 100
AFVTCGTVGL FLLLKGRKGR GVTCFLMMLS LLVSLRYMVW RLTTTLELHS
110 120 130 140 150
PLQAALSLLL VAAELYALLT LCLSYFQMSW PLDRKPLPLP ADTTDWPVVD
160 170 180 190 200
VYVPSYNEEL SLVRSTVLGA LAIDWPADKL NVYILDDGRR KSFHAFAMEA
210 220 230 240 250
GAGYIIRDQN NHAKAGNLNH ALRVTEGEYV VIFDCDHIPT RGFLKKTIGW
260 270 280 290 300
MMADPKLALL QTPHHFYSPD PFQRNLATGQ NVPPEGNMFY GLVQDGNDFW
310 320 330 340 350
DATFFCGSCA AIRRSAVLGI GGFATETVTE DAHTALKMQR EGWHTAYLRQ
360 370 380 390 400
PLAAGLSTER LMLHIGQRVR WARGMLQIMR LDNPLLGSGL RWQQRLCYLS
410 420 430 440 450
AMSHFLFAIP RLVFLASPLA FLFLGQNIIA ASPFAILVYA FPHVFHSIGT
460 470 480 490 500
LSRVEGRWRY SFWSEIYETT LALFLVRVTI MTLLNPRKGE FNVTDKGGLL
510 520 530 540 550
QSEYFDLNAV YPNVILAVIL ALALVRGIGG MMWEYHDRLA LQSFALNTLW
560 570 580 590 600
VAVSLIIVLA SIAVGRETRQ IRHKPRVRAT LPITLIDEHG QHYHAHTSDI
610 620 630 640 650
SLGGIAARLS TEHALPTQTR VTMLYHNEKD GIDVRIPAVI LFSKPGQLHL
660 670 680 690 700
QWSVDDLDVE RQIVEFMFGR NDAWSNWGDF QPDRPVRSFL MVLRSIGGLF
710 720 730 740 750
RRGQRLFRWQ APQEAPLAES EHVEEEKLEK KSLVLKPVRR SARHGATASL
760 770 780 790 800
IVLLGLPAAI APSLAQAPSR ATPVATEQGA TPVEPPPVNA PPPPSLPQPP
810 820 830 840 850
GTLPTPPQIA PASAGELLPA ATAVSLPTGP ATQQMRERLS ERTGVSPASP
860 870 880 890 900
FGDTNTGALP ADPSAPPIDP ADAARVADGE ITRTSTFRDL GLATGPLTLR
910 920 930 940 950
GFSPLQGLDV IVPANRVVTR ARITLSGALS PSLLPEASAV SVTLNEQYVG
960 970 980 990 1000
TIRVDPEHPR FGPITFDIDP LYFTGDNKLN FHFAGEYRRD CNDLYNEVLW
1010 1020 1030 1040 1050
ARISDFSTVT LTTTRIAPDR KLSYLPAPFY DPNLRTPLRV PVVMPNPDAH
1060 1070 1080 1090 1100
GMLKASALVA SWFGKLADFR KVSFPVSTTI PASGNAIAIG ENLPIDARGT
1110 1120 1130 1140 1150
RPTGPTLSEV ENPNDRLGTI LVLTGRNAQE VEVAARVLAF SSDTLGAVGT
1160 1170 1180 1190 1200
KVVNDVTLQP RHPYDAPAFV PTDRPVRFGE LVAASDLQGG GFAPPVMALP
1210 1220 1230 1240 1250
FHLPPDLYSW RNRPYPIDLW VRTPGGPVVD LETSRLDVHL NNNYLDSFTL
1260 1270 1280 1290 1300
KPPSLWAAWS ERLVNQHAGA VEHAAALPPW LLFGQNQLKF SFDARPIDRG
1310 1320 1330 1340 1350
VCRRTPDDIH MSVDSDSWLD FRRGYHFARL PNLSYFAEAA FPFSRMADLS
1360 1370 1380 1390 1400
ETTVVVPHHI DAGTAGTFMD LMGFFGATTW YPASGVQVAD INDLSEHPPQ
1410 1420 1430 1440 1450
GDILILATAG DAPKFEELLT RAPYELTDGH IRVGQHMGLQ GIWYLFQDHD
1460 1470 1480 1490 1500
HAGLQDGVQA NLNAPIAGAG VLLGAQSPYR SDRSVVALMG DTPSRMHDLV
1510 1520 1530 1540 1550
MGLRSKEDVP RIQGDLVLRN GDRLTSYRTA PTFTMGSLPW WMWLDWYLGT
1560 1570 1580 1590
RPLTLYVLGL VGAGLVAAAA VRLLRRRAQH RLEEAARVKD TTDASH
Length:1,596
Mass (Da):175,801
Last modified:November 1, 1996 - v1
Checksum:iD98A6F6259E1F3CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15957 Genomic DNA. Translation: AAA85264.1.
PIRiT31338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15957 Genomic DNA. Translation: AAA85264.1 .
PIRi T31338.

3D structure databases

ProteinModelPortali Q59167.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT2. Glycosyltransferase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR003919. Cell_synth_A.
IPR003920. Cell_synth_B.
IPR018513. Cell_synthase_bac.
IPR005150. Cellulose_synth.
IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR009875. PilZ_domain.
[Graphical view ]
Pfami PF03170. BcsB. 1 hit.
PF03552. Cellulose_synt. 1 hit.
PF00535. Glycos_transf_2. 1 hit.
PF07238. PilZ. 1 hit.
[Graphical view ]
PRINTSi PR01440. CELLSNTHASEB.
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR03030. CelA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of a second cellulose synthase gene (acsAII) in Acetobacter xylinum."
    Saxena I.M., Brown R.M. Jr.
    J. Bacteriol. 177:5276-5283(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 23769 / NCIMB 8246.

Entry informationi

Entry nameiACSA2_KOMHA
AccessioniPrimary (citable) accession number: Q59167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

It is not essential for cellulose production in this strain.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3