SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q59167

- ACSA2_KOMHA

UniProt

Q59167 - ACSA2_KOMHA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cellulose synthase 2

Gene
acsAII
Organism
Komagataeibacter hansenii (Gluconacetobacter hansenii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei187 – 1871 Reviewed prediction
Binding sitei234 – 2341Substrate Reviewed prediction
Binding sitei236 – 2361Substrate Reviewed prediction
Active sitei331 – 3311 Reviewed prediction

GO - Molecular functioni

  1. cellulose synthase (UDP-forming) activity Source: UniProtKB-EC
  2. cyclic-di-GMP binding Source: InterPro

GO - Biological processi

  1. cellulose biosynthetic process Source: UniProtKB-KW
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cellulose biosynthesis

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Cellulose synthase 2
Including the following 2 domains:
Cellulose synthase catalytic subunit [UDP-forming] (EC:2.4.1.12)
Cyclic di-GMP-binding domain
Alternative name(s):
Cellulose synthase 2 regulatory domain
Gene namesi
Name:acsAII
OrganismiKomagataeibacter hansenii (Gluconacetobacter hansenii)
Taxonomic identifieri436 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeKomagataeibacter

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Reviewed predictionAdd
BLAST
Transmembranei106 – 12621Helical; Reviewed predictionAdd
BLAST
Transmembranei396 – 41621Helical; Reviewed predictionAdd
BLAST
Transmembranei421 – 44121Helical; Reviewed predictionAdd
BLAST
Transmembranei505 – 52521Helical; Reviewed predictionAdd
BLAST
Transmembranei544 – 56421Helical; Reviewed predictionAdd
BLAST
Transmembranei1553 – 157321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15961596Cellulose synthase 2PRO_0000059261Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ59167.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini570 – 669100PilZAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 749749CatalyticAdd
BLAST
Regioni145 – 23894Catalytic subdomain AAdd
BLAST
Regioni315 – 37561Catalytic subdomain BAdd
BLAST
Regioni750 – 1596847Cyclic di-GMP binding Reviewed predictionAdd
BLAST

Domaini

There are two conserved domains in the globular part of the catalytic subunit: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site.

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 2 family.
In the C-terminal section; belongs to the AcsB/BcsB family.
Contains 1 PilZ domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003919. Cell_synth_A.
IPR003920. Cell_synth_B.
IPR018513. Cell_synthase_bac.
IPR005150. Cellulose_synth.
IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR009875. PilZ_domain.
[Graphical view]
PfamiPF03170. BcsB. 1 hit.
PF03552. Cellulose_synt. 1 hit.
PF00535. Glycos_transf_2. 1 hit.
PF07238. PilZ. 1 hit.
[Graphical view]
PRINTSiPR01440. CELLSNTHASEB.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03030. CelA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59167-1 [UniParc]FASTAAdd to Basket

« Hide

MIYRAILKRL RLEQLARVPA VSAASPFVMM AVGVFLMLMA GGVTISTTSQ     50
AFVTCGTVGL FLLLKGRKGR GVTCFLMMLS LLVSLRYMVW RLTTTLELHS 100
PLQAALSLLL VAAELYALLT LCLSYFQMSW PLDRKPLPLP ADTTDWPVVD 150
VYVPSYNEEL SLVRSTVLGA LAIDWPADKL NVYILDDGRR KSFHAFAMEA 200
GAGYIIRDQN NHAKAGNLNH ALRVTEGEYV VIFDCDHIPT RGFLKKTIGW 250
MMADPKLALL QTPHHFYSPD PFQRNLATGQ NVPPEGNMFY GLVQDGNDFW 300
DATFFCGSCA AIRRSAVLGI GGFATETVTE DAHTALKMQR EGWHTAYLRQ 350
PLAAGLSTER LMLHIGQRVR WARGMLQIMR LDNPLLGSGL RWQQRLCYLS 400
AMSHFLFAIP RLVFLASPLA FLFLGQNIIA ASPFAILVYA FPHVFHSIGT 450
LSRVEGRWRY SFWSEIYETT LALFLVRVTI MTLLNPRKGE FNVTDKGGLL 500
QSEYFDLNAV YPNVILAVIL ALALVRGIGG MMWEYHDRLA LQSFALNTLW 550
VAVSLIIVLA SIAVGRETRQ IRHKPRVRAT LPITLIDEHG QHYHAHTSDI 600
SLGGIAARLS TEHALPTQTR VTMLYHNEKD GIDVRIPAVI LFSKPGQLHL 650
QWSVDDLDVE RQIVEFMFGR NDAWSNWGDF QPDRPVRSFL MVLRSIGGLF 700
RRGQRLFRWQ APQEAPLAES EHVEEEKLEK KSLVLKPVRR SARHGATASL 750
IVLLGLPAAI APSLAQAPSR ATPVATEQGA TPVEPPPVNA PPPPSLPQPP 800
GTLPTPPQIA PASAGELLPA ATAVSLPTGP ATQQMRERLS ERTGVSPASP 850
FGDTNTGALP ADPSAPPIDP ADAARVADGE ITRTSTFRDL GLATGPLTLR 900
GFSPLQGLDV IVPANRVVTR ARITLSGALS PSLLPEASAV SVTLNEQYVG 950
TIRVDPEHPR FGPITFDIDP LYFTGDNKLN FHFAGEYRRD CNDLYNEVLW 1000
ARISDFSTVT LTTTRIAPDR KLSYLPAPFY DPNLRTPLRV PVVMPNPDAH 1050
GMLKASALVA SWFGKLADFR KVSFPVSTTI PASGNAIAIG ENLPIDARGT 1100
RPTGPTLSEV ENPNDRLGTI LVLTGRNAQE VEVAARVLAF SSDTLGAVGT 1150
KVVNDVTLQP RHPYDAPAFV PTDRPVRFGE LVAASDLQGG GFAPPVMALP 1200
FHLPPDLYSW RNRPYPIDLW VRTPGGPVVD LETSRLDVHL NNNYLDSFTL 1250
KPPSLWAAWS ERLVNQHAGA VEHAAALPPW LLFGQNQLKF SFDARPIDRG 1300
VCRRTPDDIH MSVDSDSWLD FRRGYHFARL PNLSYFAEAA FPFSRMADLS 1350
ETTVVVPHHI DAGTAGTFMD LMGFFGATTW YPASGVQVAD INDLSEHPPQ 1400
GDILILATAG DAPKFEELLT RAPYELTDGH IRVGQHMGLQ GIWYLFQDHD 1450
HAGLQDGVQA NLNAPIAGAG VLLGAQSPYR SDRSVVALMG DTPSRMHDLV 1500
MGLRSKEDVP RIQGDLVLRN GDRLTSYRTA PTFTMGSLPW WMWLDWYLGT 1550
RPLTLYVLGL VGAGLVAAAA VRLLRRRAQH RLEEAARVKD TTDASH 1596
Length:1,596
Mass (Da):175,801
Last modified:November 1, 1996 - v1
Checksum:iD98A6F6259E1F3CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15957 Genomic DNA. Translation: AAA85264.1.
PIRiT31338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15957 Genomic DNA. Translation: AAA85264.1 .
PIRi T31338.

3D structure databases

ProteinModelPortali Q59167.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT2. Glycosyltransferase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR003919. Cell_synth_A.
IPR003920. Cell_synth_B.
IPR018513. Cell_synthase_bac.
IPR005150. Cellulose_synth.
IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR009875. PilZ_domain.
[Graphical view ]
Pfami PF03170. BcsB. 1 hit.
PF03552. Cellulose_synt. 1 hit.
PF00535. Glycos_transf_2. 1 hit.
PF07238. PilZ. 1 hit.
[Graphical view ]
PRINTSi PR01440. CELLSNTHASEB.
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR03030. CelA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of a second cellulose synthase gene (acsAII) in Acetobacter xylinum."
    Saxena I.M., Brown R.M. Jr.
    J. Bacteriol. 177:5276-5283(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 23769 / NCIMB 8246.

Entry informationi

Entry nameiACSA2_KOMHA
AccessioniPrimary (citable) accession number: Q59167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

It is not essential for cellulose production in this strain.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi