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Protein

ATP synthase subunit c

Gene

atpE2

Organism
Acetobacterium woodii
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

F1F0 ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F1 containing the extramembraneous catalytic core and F0 containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation.UniRule annotation
Key component of the F0 channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F1 delta and epsilon subunits.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei62Reversibly protonated during proton transportUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesisUniRule annotation, Hydrogen ion transport, Ion transport, Transport
LigandLipid-bindingUniRule annotation

Protein family/group databases

TCDBi3.A.2.1.5. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
3.A.2.1.8. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit cUniRule annotation
Alternative name(s):
ATP synthase F(0) sector subunit cUniRule annotation
F-type ATPase subunit cUniRule annotation
Short name:
F-ATPase subunit cUniRule annotation
Lipid-binding proteinUniRule annotation
Gene namesi
Name:atpE2Imported
Synonyms:atpEUniRule annotation, atpE3Imported
OrganismiAcetobacterium woodiiImported
Taxonomic identifieri33952 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeAcetobacterium

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 33HelicalUniRule annotationAdd BLAST28
Transmembranei54 – 78HelicalUniRule annotationAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, CF(0)UniRule annotation, Membrane

Interactioni

Subunit structurei

F-type ATPases have 2 components, F1 - the catalytic core - and F0 - the membrane proton channel. F1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. F0 has three main subunits: a1, b2 and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F1 is attached to F0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.SAAS annotation

Protein-protein interaction databases

STRINGi931626.Awo_c02180.

Structurei

3D structure databases

ProteinModelPortaliQ59166.
SMRiQ59166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 75ATP-synt_CInterPro annotationAdd BLAST63

Sequence similaritiesi

Belongs to the ATPase C chain family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105VH4. Bacteria.
COG0636. LUCA.

Family and domain databases

Gene3Di1.20.20.10. 1 hit.
HAMAPiMF_01396. ATP_synth_c_bact. 1 hit.
InterProiView protein in InterPro
IPR005953. ATP_synth_csu_bac/chlpt.
IPR000454. ATP_synth_F0_csu.
IPR020537. ATP_synth_F0_csu_DDCD_BS.
IPR002379. ATPase_proteolipid_c-like_dom.
PANTHERiPTHR10031. PTHR10031. 1 hit.
PfamiView protein in Pfam
PF00137. ATP-synt_C. 1 hit.
PRINTSiPR00124. ATPASEC.
SUPFAMiSSF81333. SSF81333. 1 hit.
TIGRFAMsiTIGR01260. ATP_synt_c. 1 hit.
PROSITEiView protein in PROSITE
PS00605. ATPASE_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGLDFIKAC SAIGAGIAMI AGVGPGIGQG FAAGKGAEAV GRQPEAQSDI
60 70 80
IRTMLLGAAV AETTGIYGLI VALILLFANP FF
Length:82
Mass (Da):8,182
Last modified:November 1, 1999 - v2
Checksum:i1B103E6B5640A840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10505 Genomic DNA. Translation: AAC45088.2.
U10505 Genomic DNA. Translation: AAF01475.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10505 Genomic DNA. Translation: AAC45088.2.
U10505 Genomic DNA. Translation: AAF01475.1.

3D structure databases

ProteinModelPortaliQ59166.
SMRiQ59166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi931626.Awo_c02180.

Protein family/group databases

TCDBi3.A.2.1.5. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
3.A.2.1.8. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105VH4. Bacteria.
COG0636. LUCA.

Family and domain databases

Gene3Di1.20.20.10. 1 hit.
HAMAPiMF_01396. ATP_synth_c_bact. 1 hit.
InterProiView protein in InterPro
IPR005953. ATP_synth_csu_bac/chlpt.
IPR000454. ATP_synth_F0_csu.
IPR020537. ATP_synth_F0_csu_DDCD_BS.
IPR002379. ATPase_proteolipid_c-like_dom.
PANTHERiPTHR10031. PTHR10031. 1 hit.
PfamiView protein in Pfam
PF00137. ATP-synt_C. 1 hit.
PRINTSiPR00124. ATPASEC.
SUPFAMiSSF81333. SSF81333. 1 hit.
TIGRFAMsiTIGR01260. ATP_synt_c. 1 hit.
PROSITEiView protein in PROSITE
PS00605. ATPASE_C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59166_ACEWO
AccessioniPrimary (citable) accession number: Q59166
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1999
Last modified: May 10, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.