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Protein
Submitted name:

Dihydrofolate reductase

Gene

DHFR

Organism
Plasmid R483
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydrofolate reductaseImported (EC:1.5.1.3Imported)
Gene namesi
Name:DHFRImported
Encoded oniPlasmid R483Imported
OrganismiPlasmid R483Imported
Taxonomic identifieri2489 [NCBI]
Taxonomic lineageiother sequencesplasmids

Interactioni

Protein-protein interaction databases

DIPiDIP-17001N.

Chemistry

BindingDBiQ59137.

Structurei

3D structure databases

ProteinModelPortaliQ59137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 151151DHFR (dihydrofolate reductase)InterPro annotationAdd
BLAST

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamiPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAISKNGVI GNGPDIPWSA KGEQLLFKAI TYNQWLLVGR KTFESMGALP
60 70 80 90 100
NRKYAVVTRS SFTSDNENVL IFPSIKDALT NLKKITDHVI VSGGGEIYKS
110 120 130 140 150
LIDQVDTLHI STIDIEPEGD VYFPEIPSNF RPVFTQDFAS NINYSYQIWQ

KG
Length:152
Mass (Da):17,002
Last modified:November 1, 1996 - v1
Checksum:i30620040595C6456
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00052 Genomic DNA. Translation: AAA26081.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00052 Genomic DNA. Translation: AAA26081.1.

3D structure databases

ProteinModelPortaliQ59137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-17001N.

Chemistry

BindingDBiQ59137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamiPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of the type I trimethoprim-resistant dihydrofolate reductase specified by the Escherichia coli R-plasmid R483: comparison with procaryotic and eucaryotic dihydrofolate reductases."
    Simonsen C.C., Chen E.Y., Levinson A.D.
    J. Bacteriol. 155:1001-1008(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Plasmid: R483

Entry informationi

Entry nameiQ59137_9ZZZZ
AccessioniPrimary (citable) accession number: Q59137
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.