Q59121 (PLD_ARCHD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholipase D
EC=3.1.4.4

Alternative name(s):
Choline phosphatase
PLD-A

Gene names

Name:	pld
Ordered Locus Names:	Arch_1099

Organism

Arcanobacterium haemolyticum (strain ATCC 9345 / DSM 20595 / NBRC 15585 / NCTC 8452 / 11018) [Complete proteome] [HAMAP]

Taxonomic identifier

644284 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Actinomycineae › Actinomycetaceae › Arcanobacterium

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has sphingomyelinase and hemolytic activity. Thought to act as a virulence factor.
Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate.
Sequence caution	The sequence AAA21882.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence ADH92813.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Lipid degradation Virulence
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	By similarity
	Chain	27 – 309	283	Phospholipase D		PRO_0000022065
Sites
	Active site	46	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59121 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: C34AC5B947A21725	FASTA	309	34,663
	10 20 30 40 50 60 MKTRKKIALA LSLLTGFMLP IGSAAAAPLA QEQPTTGNRP VYAIAHRVLT KQSVDDAIKI 70 80 90 100 110 120 GANALEIDFT AWRRGWWADH DGLPTSAGDT AEDILKYIAQ KRREGNNITF VWFDIKNPDY 130 140 150 160 170 180 CKDQNSVCSI TKLRDLARQT IEQEGVRALF GFYKTVGGVG WNTIANNLND KEAVALSGRK 190 200 210 220 230 240 DDIMKDFKQY ENKIKPQQRV ADNGYYNLSY GFGGCYRDEN QTCDQLRLAG EERKKGNLGK 250 260 270 280 290 300 TFGWTVSTGQ EYLAADLLNK AEVDGMIFGF KTTYFYDHAD TRNAFAGIKN WVDAHQGTHH MATNKDIPW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Arcanobacterium haemolyticum phospholipase D is genetically and functionally similar to Corynebacterium pseudotuberculosis phospholipase D." Cuevas W.A., Songer J.G. Infect. Immun. 61:4310-4316(1993) [PubMed: 8406819] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of Arcanobacterium haemolyticum type strain (11018)." Yasawong M., Teshima H., Lapidus A., Nolan M., Lucas S., Glavina Del Rio T., Tice H., Cheng J.F., Bruce D., Detter C., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K., Mikhailova N. , Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Rohde M., Sikorski J., Pukall R., Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P. Stand. Genomic Sci. 3:126-135(2010) [PubMed: 21304742] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 9345 / DSM 20595 / NBRC 15585 / NCTC 8452 / 11018.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L16583 Genomic DNA. Translation: AAA21882.1. Different initiation. CP002045 Genomic DNA. Translation: ADH92813.1. Different initiation.
PIR	I39484.
RefSeq	YP_003697432.1. NC_014218.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9261689.
GenomeReviews	Gene locus Arch_1099 in contig CP002045_GR.
KEGG	ahe:Arch_1099.
PATRIC	38111177. VBIArcHae78728_1077.
Organism-specific databases
CMR	Search...
Family and domain databases
InterPro	IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR016674. PLipase_D_bac/fun. [Graphical view]
Gene3D	G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
PIRSF	PIRSF016632. Phospholipase_actinobac/fun. 1 hit.
SUPFAM	SSF51695. PLC-like_Pdiesterase_TIM-brl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLD_ARCHD

Accession

Primary (citable) accession number: Q59121
Secondary accession number(s): D7BPG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program