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Q59119 (CYAA_AERHY) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenylate cyclase
EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene names
Name:cya
OrganismAeromonas hydrophila
Taxonomic identifier644 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Aeromonas

Protein attributes

Sequence length843 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Enzyme regulation

The regulatory domain is involved in the regulation of cyclase activity by the carbon source.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the adenylyl cyclase class-1 family.

Ontologies

Keywords
   Biological processcAMP biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLyase
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylate cyclase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 843843Adenylate cyclase
PRO_0000195668

Regions

Region1 – 537537Catalytic
Region543 – 843301Regulatory

Sequences

Sequence LengthMass (Da)Tools
Q59119 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 8DE267A02ABE8C77

FASTA84396,853
        10         20         30         40         50         60 
MLVKLDTLVA RYDELNRLKT QRALGLMSRY GQQVFQLLPV MLHFNHPLLP GYVAGDVPHG 

        70         80         90        100        110        120 
IWSFTANEAQ QAFIQDLCQN ANCQNGLTTH DKSIQGLYSM GSTSSIGQCC HSDLDIWVCH 

       130        140        150        160        170        180 
VAGLSQERLE LLDLKCQQLS KWAEQRGVDL NFFLIPEDKF RQRNDAQMQG ESCGSAQHLL 

       190        200        210        220        230        240 
LLDEFYRSAM LIAGKRLLWY LVPAEYDDRY DEYVNGLFAH GKLSQDDWLD LGGFDRIPAE 

       250        260        270        280        290        300 
EYFGSALWQL YKGIDSPYKA VLKSVLMEAY SHEYPNTRLL SVTSRDWFQH NEGMHYRLDN 

       310        320        330        340        350        360 
YCLMLDKVTN YLKSIGDMQR LDLVRRCFYL KVCDGLSHPK EDHSPAWRRE QMTQLVAYWG 

       370        380        390        400        410        420 
WSPERLHHLD HRQEWKVEDV KVAHAELLEA LMQSYRNLIQ FARRNNISES INPEDIGILS 

       430        440        450        460        470        480 
RKLYAAFESL PGKVQRINLT IAPDLSEPDL SLVQVPHGRL NRAGWYLYKH SLEPADIIGR 

       490        500        510        520        530        540 
APLEYNGYIS KLVSWAYFNG LLTPQSRVHL FNQGSDLHID NLHQFCRDLS GTFPVKYPRA 

       550        560        570        580        590        600 
TNLALSRPCE IRQLSIFLNL ETDPTSHWVG QVIEFDANAA DVFSFGRNLE CLVGSVDLVY 

       610        620        630        640        650        660 
RNSWSEIRTL HFQGDEAVVD ALTTILGKMH QDAAAPEMIE VFCYSQHFRS LVRTRFQQLV 

       670        680        690        700        710        720 
AECIELRLAR DKQQLVKTLA LGKEKYGIFF ERRGVSVKKL ENAIDFYRHI SHNKLDHLPL 

       730        740        750        760        770        780 
RLDKTHSQHL PGIVDSYASE GLVQFFFDTR DAGTNIYILD EANRVEIYQH FAGNKDELVQ 

       790        800        810        820        830        840 
GVNRFYTSSH ERFSDAGQFS NFNLPPYYEI VQVNGELEVI PYRSQGPLRD GAGQARELGS 


ATG

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References

[1]"Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
Biochimie 78:277-287(1996) [PubMed: 8874804] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 218.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X95881 Genomic DNA. Translation: CAA65130.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYAA_AERHY
AccessionPrimary (citable) accession number: Q59119
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 19, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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