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Protein

Glutaconate CoA-transferase subunit A

Gene

gctA

Organism
Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate.

Catalytic activityi

Acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA.

Pathwayi: L-glutamate degradation via hydroxyglutarate pathway

This protein is involved in step 3 of the subpathway that synthesizes crotonoyl-CoA from L-glutamate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Glutaconate CoA-transferase subunit A (gctA), Glutaconate CoA-transferase subunit B (gctB)
  4. (R)-2-hydroxyglutaryl-CoA dehydratase subunit beta (hgdB), (R)-2-hydroxyglutaryl-CoA dehydratase subunit alpha (hgdA)
  5. Glutaconyl-CoA decarboxylase subunit gamma (gcdC), Glutaconyl-CoA decarboxylase subunit beta (gcdB), Glutaconyl-CoA decarboxylase subunit delta (gcdD), Glutaconyl-CoA decarboxylase subunit alpha (gcdA)
This subpathway is part of the pathway L-glutamate degradation via hydroxyglutarate pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes crotonoyl-CoA from L-glutamate, the pathway L-glutamate degradation via hydroxyglutarate pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-1028.
BRENDAi2.8.3.12. 85.
SABIO-RKQ59111.
UniPathwayiUPA00533; UER00686.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaconate CoA-transferase subunit A (EC:2.8.3.12)
Alternative name(s):
GCT large subunit
Gene namesi
Name:gctA
Ordered Locus Names:Acfer_1819
OrganismiAcidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
Taxonomic identifieri591001 [NCBI]
Taxonomic lineageiBacteriaFirmicutesNegativicutesAcidaminococcalesAcidaminococcaceaeAcidaminococcus
Proteomesi
  • UP000001902 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001579272 – 320Glutaconate CoA-transferase subunit AAdd BLAST319

Interactioni

Subunit structurei

Heterooctamer of four A and four B subunits.

Protein-protein interaction databases

DIPiDIP-6200N.
IntActiQ59111. 1 interactor.
STRINGi591001.Acfer_1819.

Structurei

Secondary structure

1320
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 14Combined sources8
Beta strandi20 – 23Combined sources4
Helixi33 – 41Combined sources9
Beta strandi47 – 50Combined sources4
Beta strandi52 – 54Combined sources3
Helixi56 – 63Combined sources8
Beta strandi67 – 75Combined sources9
Turni78 – 80Combined sources3
Beta strandi81 – 83Combined sources3
Helixi85 – 93Combined sources9
Beta strandi96 – 100Combined sources5
Helixi103 – 115Combined sources13
Beta strandi118 – 123Combined sources6
Helixi129 – 132Combined sources4
Helixi138 – 142Combined sources5
Beta strandi153 – 157Combined sources5
Beta strandi160 – 169Combined sources10
Beta strandi174 – 183Combined sources10
Helixi198 – 204Combined sources7
Beta strandi205 – 215Combined sources11
Helixi218 – 222Combined sources5
Helixi225 – 227Combined sources3
Helixi232 – 234Combined sources3
Beta strandi237 – 240Combined sources4
Turni242 – 247Combined sources6
Beta strandi248 – 250Combined sources3
Turni251 – 253Combined sources3
Helixi258 – 267Combined sources10
Helixi271 – 281Combined sources11
Turni282 – 284Combined sources3
Helixi288 – 295Combined sources8
Helixi297 – 301Combined sources5
Turni307 – 309Combined sources3
Helixi315 – 317Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1POIX-ray2.50A/C2-318[»]
ProteinModelPortaliQ59111.
SMRiQ59111.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ59111.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DMN. Bacteria.
COG1788. LUCA.
HOGENOMiHOG000011749.
KOiK01039.
OMAiCVLPTWA.
OrthoDBiPOG091H08PU.

Family and domain databases

InterProiIPR004165. CoA_trans_fam_I.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVMTLKDA IAKYVHSGDH IALGGFTTDR KPYAAVFEIL RQGITDLTGL
60 70 80 90 100
GGAAGGDWDM LIGNGRVKAY INCYTANSGV TNVSRRFRKW FEAGKLTMED
110 120 130 140 150
YSQDVIYMMW HAAALGLPFL PVTLMQGSGL TDEWGISKEV RKTLDKVPDD
160 170 180 190 200
KFKYIDNPFK PGEKVVAVPV PQVDVAIIHA QQASPDGTVR IWGGKFQDVD
210 220 230 240 250
IAEAAKYTIV TCEEIISDEE IRRDPTKNDI PGMCVDAVVL APYGAHPSQC
260 270 280 290 300
YGLYDYDNPF LKVYDKVSKT QEDFDAFCKE WVFDLKDHDE YLNKLGATRL
310 320
INLKVVPGLG YHIDMTKEDK
Length:320
Mass (Da):35,722
Last modified:January 23, 2007 - v3
Checksum:iC51B214FE17FEB46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81440 Genomic DNA. Translation: CAA57199.1.
CP001859 Genomic DNA. Translation: ADB48173.1.
PIRiS51051.
RefSeqiWP_012939156.1. NC_013740.1.

Genome annotation databases

EnsemblBacteriaiADB48173; ADB48173; Acfer_1819.
KEGGiafn:Acfer_1819.
PATRICi31910229. VBIAciFer109666_1810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81440 Genomic DNA. Translation: CAA57199.1.
CP001859 Genomic DNA. Translation: ADB48173.1.
PIRiS51051.
RefSeqiWP_012939156.1. NC_013740.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1POIX-ray2.50A/C2-318[»]
ProteinModelPortaliQ59111.
SMRiQ59111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6200N.
IntActiQ59111. 1 interactor.
STRINGi591001.Acfer_1819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB48173; ADB48173; Acfer_1819.
KEGGiafn:Acfer_1819.
PATRICi31910229. VBIAciFer109666_1810.

Phylogenomic databases

eggNOGiENOG4105DMN. Bacteria.
COG1788. LUCA.
HOGENOMiHOG000011749.
KOiK01039.
OMAiCVLPTWA.
OrthoDBiPOG091H08PU.

Enzyme and pathway databases

UniPathwayiUPA00533; UER00686.
BioCyciMetaCyc:MONOMER-1028.
BRENDAi2.8.3.12. 85.
SABIO-RKQ59111.

Miscellaneous databases

EvolutionaryTraceiQ59111.

Family and domain databases

InterProiIPR004165. CoA_trans_fam_I.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCTA_ACIFV
AccessioniPrimary (citable) accession number: Q59111
Secondary accession number(s): D2RM71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.