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Q59110 (DSRB_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sulfite reductase, dissimilatory-type subunit beta
EC=1.8.99.3
Alternative name(s):
Hydrogensulfite reductase subunit beta
Gene names
Name:dsrB
Ordered Locus Names:AF_0424
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus ›

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the reduction of sulfite to sulfide. This is the terminal oxidation reaction in sulfate respiration.

Catalytic activity

(O3S.S.SO3)2- + acceptor + 2 H2O + OH- = 3 HSO3- + reduced acceptor.

Cofactor

Binds 1 4Fe-4S cluster per subunit.

Binds 2 sirohemes per subunit.

Subunit structure

Heterotetramer of two alpha and two beta subunits.

Subcellular location

Membrane. Note: Although the protein complex is found in the soluble fraction it may be membrane-associated in vivo.

Sequence similarities

Contains 1 4Fe-4S ferredoxin-type domain.

Biophysicochemical properties

Temperature dependence:

Highly thermostable. Inactive towards methylviologen below 55 degrees Celsius.

Sequence caution

The sequence AAB90811.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Sulfite reductase, dissimilatory-type subunit beta
PRO_0000080027

Regions

Domain232 – 262314Fe-4S ferredoxin-type

Sites

Metal binding1401Iron (heme axial ligand) Potential
Metal binding1781Iron (heme axial ligand) Potential
Metal binding1821Iron (heme axial ligand) Potential
Metal binding2201Iron-sulfur (4Fe-4S) Potential
Metal binding2411Iron-sulfur (4Fe-4S) Potential
Metal binding2441Iron-sulfur (4Fe-4S) Potential
Metal binding2471Iron-sulfur (4Fe-4S) Potential

Secondary structure

1 ...................................................................... 366
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q59110 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BA8E4C59216459DA

FASTA36641,570
        10         20         30         40         50         60 
MVVEGVKTDF GPPYFRDLLH PVIAKNYGKW KYHEVVKPGV IKRVAESGDV IYVVRFGTPR 

        70         80         90        100        110        120 
LLSIYTVREL CDIADKYSDG YLRWTSRNNV EFFVTDESKI DDLINEVQER VGFPCGGTWD 

       130        140        150        160        170        180 
AVKGEYGLSN IVHTQGWIHC HTPAIDASGI VKAVMDELYE YFTDHKLPAM CRISLACCAN 

       190        200        210        220        230        240 
MCGAVHASDI AIVGIHRTPP IPNDEAIRKT CEIPSTVAAC PTGALKPDMK NKTIKVDVEK 

       250        260        270        280        290        300 
CMYCGNCYTM CPGMPLFDPE NDGAAIMVGG KLSEARRMPE LSKVVVPWVP NEPPRWPTLV 

       310        320        330        340        350        360 
KYVKQILEAW AANANKHERL IEWVDRIGWE RFFELTGLEF TQHLIDDYRI TPYFYSEFRA 


STQFKW

« Hide

References

« Hide 'large scale' references
[1]"Dissimilatory sulphite reductase from Archaeoglobus fulgidus: physico-chemical properties of the enzyme and cloning, sequencing and analysis of the reductase genes."
Dahl C., Kredich N.M., Deutzmann R., Trueper H.G.
J. Gen. Microbiol. 139:1817-1828(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 332-359.
Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
[2]"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. expand/collapse author list , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M95624 Genomic DNA. Translation: AAB17214.1.
AE000782 Genomic DNA. Translation: AAB90811.1. Different initiation.
PIRH69302.
RefSeqNP_069260.1. NC_000917.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3MM5X-ray1.80B/E1-366[»]
3MM6X-ray1.90B/E1-366[»]
3MM7X-ray1.90B/E1-366[»]
3MM8X-ray2.28B/E1-366[»]
3MM9X-ray2.10B/E1-366[»]
3MMAX-ray2.30B/E1-366[»]
3MMBX-ray2.30B/E1-366[»]
3MMCX-ray2.04B/E1-366[»]
ProteinModelPortalQ59110.
SMRQ59110. Positions 4-366.
ModBaseSearch...

Protein-protein interaction databases

STRING224325.AF0424.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB90811; AAB90811; AF_0424.
GeneID1483640.
KEGGafu:AF0424.

Phylogenomic databases

eggNOGCOG2221.
KOK11181.
OMAWLHCDIP.
ProtClustDBCLSK862601.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-435-MONOMER.
MetaCyc:MONOMER-12501.

Family and domain databases

InterProIPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR011808. DsrB.
IPR005117. NiRdtase/SiRdtase_haem-b_fer.
IPR006067. NO2/SO3_Rdtase_4Fe4S_dom.
[Graphical view]
PfamPF00037. Fer4. 1 hit.
PF01077. NIR_SIR. 1 hit.
PF03460. NIR_SIR_ferr. 1 hit.
[Graphical view]
SUPFAMSSF55124. NiR_SiRalpha_1/3. 1 hit.
TIGRFAMsTIGR02066. dsrB. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ59110.

Entry information

Entry nameDSRB_ARCFU
AccessionPrimary (citable) accession number: Q59110
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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