Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sulfite reductase, dissimilatory-type subunit beta

Gene

dsrB

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of sulfite to sulfide. This is the terminal oxidation reaction in sulfate respiration.1 Publication

Catalytic activityi

Hydrogen sulfide + a [DsrC protein]-disulfide + 2 acceptor + 3 H2O = sulfite + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+.2 Publications
A [DsrC protein]-S-sulfanyl-L-cysteine + 3 acceptor + 3 H2O = sulfite + a [DsrC protein]-disulfide + 3 reduced acceptor + 2 H+.2 Publications

Cofactori

Protein has several cofactor binding sites:

Temperature dependencei

Highly thermostable. Inactive towards methylviologen below 55 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi140Iron-sulfur (4Fe-4S) 1Combined sources2 Publications1
Metal bindingi177Iron-sulfur (4Fe-4S) 1Combined sources2 Publications1
Metal bindingi178Iron-sulfur (4Fe-4S) 1Combined sources2 Publications1
Metal bindingi182Iron (siroheme axial ligand)2 Publications1
Metal bindingi182Iron-sulfur (4Fe-4S) 1Combined sources2 Publications1
Metal bindingi220Iron-sulfur (4Fe-4S) 2Combined sources2 Publications1
Metal bindingi241Iron-sulfur (4Fe-4S) 2Combined sources2 Publications1
Metal bindingi244Iron-sulfur (4Fe-4S) 2Combined sources2 Publications1
Metal bindingi247Iron-sulfur (4Fe-4S) 2Combined sources2 Publications1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Heme, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-12501
BRENDAi1.8.99.3 414

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite reductase, dissimilatory-type subunit beta (EC:1.8.99.52 Publications)
Alternative name(s):
Hydrogensulfite reductase subunit beta
Gene namesi
Name:dsrB
Ordered Locus Names:AF_0424
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

  • Membrane
  • Note: Although the protein complex is found in the soluble fraction it may be membrane-associated in vivo.

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000800271 – 366Sulfite reductase, dissimilatory-type subunit betaAdd BLAST366

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.2 Publications

Protein-protein interaction databases

STRINGi224325.AF0424

Structurei

Secondary structure

1366
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 18Combined sources4
Helixi21 – 26Combined sources6
Beta strandi30 – 37Combined sources8
Beta strandi40 – 45Combined sources6
Beta strandi50 – 56Combined sources7
Beta strandi60 – 63Combined sources4
Helixi64 – 77Combined sources14
Beta strandi81 – 84Combined sources4
Beta strandi90 – 95Combined sources6
Helixi97 – 99Combined sources3
Helixi100 – 111Combined sources12
Turni121 – 124Combined sources4
Helixi136 – 139Combined sources4
Helixi148 – 157Combined sources10
Helixi159 – 163Combined sources5
Beta strandi167 – 169Combined sources3
Beta strandi173 – 178Combined sources6
Beta strandi182 – 184Combined sources3
Helixi185 – 187Combined sources3
Beta strandi188 – 195Combined sources8
Helixi204 – 210Combined sources7
Helixi213 – 218Combined sources6
Beta strandi225 – 228Combined sources4
Turni229 – 232Combined sources4
Beta strandi233 – 236Combined sources4
Helixi238 – 240Combined sources3
Helixi246 – 250Combined sources5
Turni259 – 261Combined sources3
Beta strandi263 – 268Combined sources6
Beta strandi275 – 277Combined sources3
Beta strandi283 – 290Combined sources8
Turni293 – 295Combined sources3
Helixi297 – 313Combined sources17
Helixi320 – 327Combined sources8
Helixi329 – 336Combined sources8
Helixi342 – 344Combined sources3
Beta strandi350 – 352Combined sources3
Helixi353 – 357Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MM5X-ray1.80B/E1-366[»]
3MM6X-ray1.90B/E1-366[»]
3MM7X-ray1.90B/E1-366[»]
3MM8X-ray2.28B/E1-366[»]
3MM9X-ray2.10B/E1-366[»]
3MMAX-ray2.30B/E1-366[»]
3MMBX-ray2.30B/E1-366[»]
3MMCX-ray2.04B/E1-366[»]
ProteinModelPortaliQ59110
SMRiQ59110
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ59110

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 2624Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Phylogenomic databases

eggNOGiarCOG02059 Archaea
COG2221 LUCA
KOiK11181
OMAiINTCTAF
OrthoDBiPOG093Z0395

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR011808 DsrB
IPR005117 NiRdtase/SiRdtase_haem-b_fer
IPR036136 Nit/Sulf_reduc_fer_like_dom_sf
IPR006067 NO2/SO3_Rdtase_4Fe4S_dom
PfamiView protein in Pfam
PF00037 Fer4, 1 hit
PF01077 NIR_SIR, 1 hit
PF03460 NIR_SIR_ferr, 1 hit
SUPFAMiSSF55124 SSF55124, 1 hit
TIGRFAMsiTIGR02066 dsrB, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q59110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVEGVKTDF GPPYFRDLLH PVIAKNYGKW KYHEVVKPGV IKRVAESGDV
60 70 80 90 100
IYVVRFGTPR LLSIYTVREL CDIADKYSDG YLRWTSRNNV EFFVTDESKI
110 120 130 140 150
DDLINEVQER VGFPCGGTWD AVKGEYGLSN IVHTQGWIHC HTPAIDASGI
160 170 180 190 200
VKAVMDELYE YFTDHKLPAM CRISLACCAN MCGAVHASDI AIVGIHRTPP
210 220 230 240 250
IPNDEAIRKT CEIPSTVAAC PTGALKPDMK NKTIKVDVEK CMYCGNCYTM
260 270 280 290 300
CPGMPLFDPE NDGAAIMVGG KLSEARRMPE LSKVVVPWVP NEPPRWPTLV
310 320 330 340 350
KYVKQILEAW AANANKHERL IEWVDRIGWE RFFELTGLEF TQHLIDDYRI
360
TPYFYSEFRA STQFKW
Length:366
Mass (Da):41,570
Last modified:November 1, 1996 - v1
Checksum:iBA8E4C59216459DA
GO

Sequence cautioni

The sequence AAB90811 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95624 Genomic DNA Translation: AAB17214.1
AE000782 Genomic DNA Translation: AAB90811.1 Different initiation.
PIRiH69302
RefSeqiWP_048064231.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB90811; AAB90811; AF_0424
GeneIDi24793962
KEGGiafu:AF_0424

Similar proteinsi

Entry informationi

Entry nameiDSRB_ARCFU
AccessioniPrimary (citable) accession number: Q59110
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health