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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-2293-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
Ordered Locus Names:H16_A2325
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9509502-oxoglutarate dehydrogenase E1 componentPRO_0000162160Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi381666.H16_A2325.

Structurei

3D structure databases

ProteinModelPortaliQ59106.
SMRiQ59106. Positions 88-941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQQYQSNSY LFGGNAPYVE ELYEAYLQNP ASVPDNWRAY FDAMQNVPAV
60 70 80 90 100
DGSNGRDIPH APIVASFAER AKQGPIRTIV ASADSDMGRK RVAATQLIAA
110 120 130 140 150
YRNIGSHWAD LDPLKRQERP PLPDLDPAFY GFSEADLDIV FNASNTYFGK
160 170 180 190 200
ESMSLRELLN NLRETYCGTI GFEFMYVSDQ AQKRWWQERL ETTRSKPVFT
210 220 230 240 250
LEKKKHILDR LTAAEGLERF LHTKYVGQKR FSLEGGESFI AAMDELIQHA
260 270 280 290 300
GSKGVQEIVI GMAHRGRLNV LVNTLGKMPA DLFAEFEGKH VDDLPAGDVK
310 320 330 340 350
YHKGFSSDVS TEGGPVHLSL AFNPSHLEIV NPVVEGSAKA RQERRGEVGH
360 370 380 390 400
KEVLPVQVHG DAAFAGQGVV METLNLAQTR GYGTGGSMHI VINNQIGFTT
410 420 430 440 450
SDPRDARSTL YCTDVVKMIE APVLHVNGDD PEAVVYAMQL AVDFRMEFKK
460 470 480 490 500
DVVVDIICFR KLGHNEQDTP AVTQPLMYKK IAQHPGTRKL YADKLAAQNL
510 520 530 540 550
VPAEFGDEKV KAYRAAMDAG KHTADPVLSN FKNKFAVDWM PFLNRKWTDA
560 570 580 590 600
ADTAVPVTEL KRLAERITTT PETLKLHPLV EKVVKDRANM GRGDQPLDWG
610 620 630 640 650
MGEHLAFASL VSSGYPVRIT GQDAGRGTFT HRHAVLHDQA RERWDAGSYV
660 670 680 690 700
PLQNVSENQA PFTVIDSVLS EEAVLGFEYG YSAAEPNALV IWEAQFGDFV
710 720 730 740 750
NGAQVVIDQF ISSGEVKWGR ASGLTLMLPH GYEGQGPEHS SARIERFLQL
760 770 780 790 800
CADHNMQVCQ PTTPAQIFHL LRRQMIRLFR KPLVIMTPKS LLRNKDAVSP
810 820 830 840 850
LSDLAKGHFE TVIPDHEELN ASKVKRVIMC SGKVYYDLVN TRKEREANDT
860 870 880 890 900
AVIRLEQLYP FPHKAVAAEL KKYPNATEIV WCQDEPQNQG AWFFVQHYIM
910 920 930 940 950
ENMTDGQKLG YAGRPASASP AVGYYAKHNE QQKALLEAAF AKLKGFVLTK
Length:950
Mass (Da):105,996
Last modified:January 23, 2007 - v2
Checksum:i531BC77561D2ECCF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti621 – 6211G → A in CAA62980 (PubMed:8867378).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91877 Genomic DNA. Translation: CAA62980.1.
AM260479 Genomic DNA. Translation: CAJ93421.1.
PIRiT44422.
RefSeqiWP_010809464.1. NC_008313.1.
YP_726789.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ93421; CAJ93421; H16_A2325.
GeneIDi4249723.
KEGGireh:H16_A2325.
PATRICi35234169. VBIRalEut6770_2731.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91877 Genomic DNA. Translation: CAA62980.1.
AM260479 Genomic DNA. Translation: CAJ93421.1.
PIRiT44422.
RefSeqiWP_010809464.1. NC_008313.1.
YP_726789.1. NC_008313.1.

3D structure databases

ProteinModelPortaliQ59106.
SMRiQ59106. Positions 88-941.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381666.H16_A2325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ93421; CAJ93421; H16_A2325.
GeneIDi4249723.
KEGGireh:H16_A2325.
PATRICi35234169. VBIRalEut6770_2731.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-2293-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the Alcaligenes eutrophus 2-oxoglutarate dehydrogenase complex."
    Hein S., Steinbuechel A.
    FEMS Microbiol. Lett. 136:231-238(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiODO1_CUPNH
AccessioniPrimary (citable) accession number: Q59106
Secondary accession number(s): Q0K9A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 27, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.