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Q59097

- ODP1_CUPNH

UniProt

Q59097 - ODP1_CUPNH

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Protein

Pyruvate dehydrogenase E1 component

Gene

pdhA

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate.By similarity

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-1371-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:pdhA
Ordered Locus Names:H16_A1374
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 895895Pyruvate dehydrogenase E1 componentPRO_0000162238Add
BLAST

Proteomic databases

PRIDEiQ59097.

Interactioni

Subunit structurei

Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

Protein-protein interaction databases

STRINGi381666.H16_A1374.

Structurei

3D structure databases

ProteinModelPortaliQ59097.
SMRiQ59097. Positions 65-892.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2609.
HOGENOMiHOG000115215.
KOiK00163.
OMAiANMIPNC.
OrthoDBiEOG6BW4TW.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59097-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAVPEQILG ASSANDADPQ ETHEWLDALQ GVLAAEGPAR AAFLIDKQIE
60 70 80 90 100
YARVNGVTQP FHAETQYINT IPVEQQARIP GDQDIEHRIR SYTRWNAMAM
110 120 130 140 150
VLRANKHTNV GGHISSFASA ATLYDVGYNH FWRAPSEAGG GDLVFVQGHS
160 170 180 190 200
APGVYSRAFL LGRLTQDQLD NFRQEVDGKG ISSYPHPWLM PDFWQFPTVS
210 220 230 240 250
MGLGPIMAIY QARFMKYLDS RGLAKAGDRK VWAFLGDGET DEPESLGAIG
260 270 280 290 300
MAGREKLDNL VFVINCNLQR LDGPVRGNGK IIQELESEFR GAGWNVIKVV
310 320 330 340 350
WGSKWDSLLA RDTKGLLMKR MMECVDGEYQ TMKAKDGAYV REHFFNTPEL
360 370 380 390 400
KAMVADWSDD DIWRLNRGGH DPHKIYAAYK AASEHKGQPT LILAKTIKGY
410 420 430 440 450
GMGDAGQAMN VAHQQKKMPV DAIRKFRDQF NLPVADDQLE EVPYITFPEG
460 470 480 490 500
SKELEYMRQA RQNLGGYLPA RRQKAEALPV PQLSAFDALL KATGEGREVS
510 520 530 540 550
TTMAFVRILN TLLKDKQIGK HVVPIVPDES RTFGMEGLFR QVGIWNQEGQ
560 570 580 590 600
KYVPEDHDQL MFYKESQTGQ VLQEGINEAG AMCDWIAAAT SYSTHGVQMI
610 620 630 640 650
PFYIYYSMFG IQRIGDLCWA AADMRSRGFL LGGTAGRTTL NGEGLQHEDG
660 670 680 690 700
HSHVFHAAIP NCISYDPTFQ YELAVVMQDG LRRMYAEQED VYYYLTVMNE
710 720 730 740 750
NYEHPEMPAG VEQDIVKGMY QFRKGVENSN APRVQLLGSG TIFREVIAAA
760 770 780 790 800
DLLKKDWGVE SDLWGCPSFT ELAREGHDVE RFNLLHPTET PRESHVAKSL
810 820 830 840 850
KSARGPVIAS TDYVRAFAEQ IRPFVPRRYV VLGTDGFGRS DTREKLRHFF
860 870 880 890
EVDRYWVTLA ALKALADEGA IGRDKVAEAI KKYNLDPNKP NPMSV
Length:895
Mass (Da):100,365
Last modified:November 1, 1996 - v1
Checksum:i522A9A3C43454051
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09865 Genomic DNA. Translation: AAA21598.1.
AM260479 Genomic DNA. Translation: CAJ92510.1.
PIRiA55514.
RefSeqiWP_011615027.1. NC_008313.1.
YP_725878.1. NC_008313.1.

Genome annotation databases

EnsemblBacteriaiCAJ92510; CAJ92510; H16_A1374.
GeneIDi4250135.
KEGGireh:H16_A1374.
PATRICi35232211. VBIRalEut6770_1763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09865 Genomic DNA. Translation: AAA21598.1 .
AM260479 Genomic DNA. Translation: CAJ92510.1 .
PIRi A55514.
RefSeqi WP_011615027.1. NC_008313.1.
YP_725878.1. NC_008313.1.

3D structure databases

ProteinModelPortali Q59097.
SMRi Q59097. Positions 65-892.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.H16_A1374.

Proteomic databases

PRIDEi Q59097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ92510 ; CAJ92510 ; H16_A1374 .
GeneIDi 4250135.
KEGGi reh:H16_A1374.
PATRICi 35232211. VBIRalEut6770_1763.

Phylogenomic databases

eggNOGi COG2609.
HOGENOMi HOG000115215.
KOi K00163.
OMAi ANMIPNC.
OrthoDBi EOG6BW4TW.

Enzyme and pathway databases

BioCyci CNEC381666:GJUJ-1371-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF00456. Transketolase_N. 2 hits.
[Graphical view ]
PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00759. aceE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Biochemical and molecular characterization of the Alcaligenes eutrophus pyruvate dehydrogenase complex and identification of a new type of dihydrolipoamide dehydrogenase."
    Hein S., Steinbuechel A.
    J. Bacteriol. 176:4394-4408(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiODP1_CUPNH
AccessioniPrimary (citable) accession number: Q59097
Secondary accession number(s): Q0KBW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3