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Reviewed, UniProtKB/Swiss-Prot Q59097 (ODP1_RALEH)

Last modified November 4, 2008. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein namesRecommended name:
    Pyruvate dehydrogenase E1 component
    EC=1.2.4.1
Gene names
Name: pdhA
Ordered Locus Names: H16_A1374
OrganismRalstonia eutropha (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)) [Complete proteome] [HAMAP]
Taxonomic identifier381666 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus

Protein attributes

Sequence length895 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Homodimer By similarity.

Ontologies

Keywords

   Biological processGlycolysis
   LigandPyruvate
Thiamine pyrophosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionpyruvate dehydrogenase (acetyl-transferring) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 895895Pyruvate dehydrogenase E1 component
PRO_0000162238

Sequences

Sequence LengthMass (Da)Tools
Q59097-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 522A9A3C43454051

FASTA895100,365
        10         20         30         40         50         60 
MSAVPEQILG ASSANDADPQ ETHEWLDALQ GVLAAEGPAR AAFLIDKQIE YARVNGVTQP 

        70         80         90        100        110        120 
FHAETQYINT IPVEQQARIP GDQDIEHRIR SYTRWNAMAM VLRANKHTNV GGHISSFASA 

       130        140        150        160        170        180 
ATLYDVGYNH FWRAPSEAGG GDLVFVQGHS APGVYSRAFL LGRLTQDQLD NFRQEVDGKG 

       190        200        210        220        230        240 
ISSYPHPWLM PDFWQFPTVS MGLGPIMAIY QARFMKYLDS RGLAKAGDRK VWAFLGDGET 

       250        260        270        280        290        300 
DEPESLGAIG MAGREKLDNL VFVINCNLQR LDGPVRGNGK IIQELESEFR GAGWNVIKVV 

       310        320        330        340        350        360 
WGSKWDSLLA RDTKGLLMKR MMECVDGEYQ TMKAKDGAYV REHFFNTPEL KAMVADWSDD 

       370        380        390        400        410        420 
DIWRLNRGGH DPHKIYAAYK AASEHKGQPT LILAKTIKGY GMGDAGQAMN VAHQQKKMPV 

       430        440        450        460        470        480 
DAIRKFRDQF NLPVADDQLE EVPYITFPEG SKELEYMRQA RQNLGGYLPA RRQKAEALPV 

       490        500        510        520        530        540 
PQLSAFDALL KATGEGREVS TTMAFVRILN TLLKDKQIGK HVVPIVPDES RTFGMEGLFR 

       550        560        570        580        590        600 
QVGIWNQEGQ KYVPEDHDQL MFYKESQTGQ VLQEGINEAG AMCDWIAAAT SYSTHGVQMI 

       610        620        630        640        650        660 
PFYIYYSMFG IQRIGDLCWA AADMRSRGFL LGGTAGRTTL NGEGLQHEDG HSHVFHAAIP 

       670        680        690        700        710        720 
NCISYDPTFQ YELAVVMQDG LRRMYAEQED VYYYLTVMNE NYEHPEMPAG VEQDIVKGMY 

       730        740        750        760        770        780 
QFRKGVENSN APRVQLLGSG TIFREVIAAA DLLKKDWGVE SDLWGCPSFT ELAREGHDVE 

       790        800        810        820        830        840 
RFNLLHPTET PRESHVAKSL KSARGPVIAS TDYVRAFAEQ IRPFVPRRYV VLGTDGFGRS 

       850        860        870        880        890 
DTREKLRHFF EVDRYWVTLA ALKALADEGA IGRDKVAEAI KKYNLDPNKP NPMSV 

« Hide

References

« Hide 'large scale' references
[1]"Biochemical and molecular characterization of the Alcaligenes eutrophus pyruvate dehydrogenase complex and identification of a new type of dihydrolipoamide dehydrogenase."
Hein S., Steinbuechel A.
J. Bacteriol. 176:4394-4408(1994) [PubMed: 8021225] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia eutropha H16."
Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I., Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.
Nat. Biotechnol. 24:1257-1262(2006) [PubMed: 16964242] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

U09865 Genomic DNA. Translation: AAA21598.1.
AM260479 Genomic DNA. Translation: CAJ92510.1.
PIRA55514.
RefSeqYP_725878.1.

3D structure databases

HSSPHSSP built from PDB template 1L8A based on UniProtKB P06958.
ModBaseSearch...

Genome annotation databases

GeneID4250135.
GenomeReviewsGene locus H16_A1374 in contig AM260479_GR.
KEGGreh:H16_A1374.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ59097.

Family and domain databases

InterProIPR004660. 2-oxoA_DHase_E1.
IPR005474. Transketo_N.
IPR015941. Transketolase_C-like.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
PfamPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
TIGRFAMsTIGR00759. aceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODP1_RALEH
AccessionPrimary (citable) accession number: Q59097
Secondary accession number(s): Q0KBW1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 4, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information