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Protein

3-oxoadipate enol-lactonase 1

Gene

pcaD

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

3-oxoadipate enol-lactone + H2O = 3-oxoadipate.

Pathwayi: beta-ketoadipate pathway

This protein is involved in step 1 of the subpathway that synthesizes 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate.
Proteins known to be involved in this subpathway in this organism are:
  1. 3-oxoadipate enol-lactonase 1 (pcaD), 3-oxoadipate enol-lactonase 2 (catD)
This subpathway is part of the pathway beta-ketoadipate pathway, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3-oxoadipate from 5-oxo-4,5-dihydro-2-furylacetate, the pathway beta-ketoadipate pathway and in Aromatic compound metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Enzyme and pathway databases

BioCyciASP62977:GJVV-1620-MONOMER.
RETL1328306-WGS:GSTH-5907-MONOMER.
UniPathwayiUPA00157; UER00261.

Protein family/group databases

ESTHERiacica-elh1. Carboxymethylbutenolide_lactonase.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoadipate enol-lactonase 1 (EC:3.1.1.24)
Alternative name(s):
3-oxoadipate enol-lactonase I
Beta-ketoadipate enol-lactone hydrolase I
Enol-lactone hydrolase I
Gene namesi
Name:pcaD
Ordered Locus Names:ACIAD1708
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2662663-oxoadipate enol-lactonase 1PRO_0000086955Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi62977.ACIAD1708.

Structurei

3D structure databases

ProteinModelPortaliQ59093.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105F2Z. Bacteria.
COG0596. LUCA.
HOGENOMiHOG000028072.
KOiK01055.
OMAiFRIWDEV.
OrthoDBiPOG091H05R7.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR026968. PcaD/CatD.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR02427. protocat_pcaD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEIHSIMIT NRQGKTLSVQ INGPENAPAI VFSNSLGTDH GMWQPQVAAL
60 70 80 90 100
KSQYRVVTYD TRGHGQSDVI ENTTLQNLGE DVLDILDALN IEKAHFCGIS
110 120 130 140 150
MGGLTALWLG IYQAARFYSI TVANSAAKIW TEDGWNARAE AVEANGLADL
160 170 180 190 200
VASTHTRWFS DKFDYKNDNL AQKTIQSLAD TPAQGYANAC RALAKADVRE
210 220 230 240 250
KLASISIPTL IIAGSADPVT TITDGEFMQQ HIQCNQFEVI DASHLSNIEQ
260
PEKFIQIFSG FVKSIQ
Length:266
Mass (Da):29,120
Last modified:August 1, 1998 - v2
Checksum:i0719C33CE56C6E77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05770 Genomic DNA. Translation: AAC37150.1.
CR543861 Genomic DNA. Translation: CAG68550.1.
RefSeqiWP_004926626.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG68550; CAG68550; ACIAD1708.
GeneIDi25684310.
KEGGiaci:ACIAD1708.
PATRICi20741186. VBIAciSp98416_1539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05770 Genomic DNA. Translation: AAC37150.1.
CR543861 Genomic DNA. Translation: CAG68550.1.
RefSeqiWP_004926626.1. NC_005966.1.

3D structure databases

ProteinModelPortaliQ59093.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62977.ACIAD1708.

Protein family/group databases

ESTHERiacica-elh1. Carboxymethylbutenolide_lactonase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG68550; CAG68550; ACIAD1708.
GeneIDi25684310.
KEGGiaci:ACIAD1708.
PATRICi20741186. VBIAciSp98416_1539.

Phylogenomic databases

eggNOGiENOG4105F2Z. Bacteria.
COG0596. LUCA.
HOGENOMiHOG000028072.
KOiK01055.
OMAiFRIWDEV.
OrthoDBiPOG091H05R7.

Enzyme and pathway databases

UniPathwayiUPA00157; UER00261.
BioCyciASP62977:GJVV-1620-MONOMER.
RETL1328306-WGS:GSTH-5907-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR026968. PcaD/CatD.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR02427. protocat_pcaD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiELH1_ACIAD
AccessioniPrimary (citable) accession number: Q59093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This species can form two 3-oxoadipate enol-lactonases in response to different inducers. The one shown is called enol-lactone hydrolase I by the authors.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.