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Protein

3-oxoadipate CoA-transferase subunit B

Gene

pcaJ

more
Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA.

Pathwayi: beta-ketoadipate pathway

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA and succinyl-CoA from 3-oxoadipate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-oxoadipate CoA-transferase subunit A (pcaI), 3-oxoadipate CoA-transferase subunit B (pcaJ)
  2. Beta-ketoadipyl-CoA thiolase (catF), Beta-ketoadipyl-CoA thiolase (pcaF)
This subpathway is part of the pathway beta-ketoadipate pathway, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA and succinyl-CoA from 3-oxoadipate, the pathway beta-ketoadipate pathway and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Enzyme and pathway databases

BioCyciASP62977:GJVV-1376-MONOMER.
ASP62977:GJVV-1617-MONOMER.
UniPathwayiUPA00157; UER00262.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoadipate CoA-transferase subunit B (EC:2.8.3.6)
Alternative name(s):
Beta-ketoadipate:succinyl-CoA transferase subunit B
Gene namesi
Name:pcaJ
Ordered Locus Names:ACIAD1705
AND
Name:catJ
Ordered Locus Names:ACIAD1449
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2172173-oxoadipate CoA-transferase subunit BPRO_0000157917Add
BLAST

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

STRINGi62977.ACIAD1705.

Structurei

3D structure databases

ProteinModelPortaliQ59091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QNJ. Bacteria.
COG2057. LUCA.
HOGENOMiHOG000221245.
KOiK01032.
OMAiANWRVGS.
OrthoDBiPOG091H0D0N.

Family and domain databases

InterProiIPR012791. 3-oxoacid_CoA-transf_B.
IPR004165. CoA_trans_fam_I.
IPR004164. CoA_transf_AS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02428. pcaJ_scoB_fam. 1 hit.
PROSITEiPS01274. COA_TRANSF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYHKLTRDQ IAQRVAQDIP EGSYVNLGIG LPTKIASYLP ADKDVFLHSE
60 70 80 90 100
NGLLAFGPPP AAGEEDPELI NAGKEYVTML EGGCFFHHGD SFAMMRGGHL
110 120 130 140 150
DICVLGAFQI AANGDLANWH TGAPDAIPSV GGAMDLAVGA KKVFVTTDHV
160 170 180 190 200
TKKGEPKIVA ELTYPATGQK CVDRIYTDLC IIDVVPEGLK VIEKVEGLSF
210
EELQRLTGAT LIDATQG
Length:217
Mass (Da):23,165
Last modified:August 31, 2004 - v2
Checksum:i7630238C4DC39D16
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391L → LM in AAC37147 (PubMed:8063101).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05770 Genomic DNA. Translation: AAC37147.1.
AF009224 Genomic DNA. Translation: AAC46433.1.
CR543861 Genomic DNA. Translation: CAG68312.1.
CR543861 Genomic DNA. Translation: CAG68547.1.
PIRiB44570.
RefSeqiWP_004925445.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG68312; CAG68312; ACIAD1449.
CAG68547; CAG68547; ACIAD1705.
GeneIDi25684307.
KEGGiaci:ACIAD1449.
aci:ACIAD1705.
PATRICi20740708. VBIAciSp98416_1306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05770 Genomic DNA. Translation: AAC37147.1.
AF009224 Genomic DNA. Translation: AAC46433.1.
CR543861 Genomic DNA. Translation: CAG68312.1.
CR543861 Genomic DNA. Translation: CAG68547.1.
PIRiB44570.
RefSeqiWP_004925445.1. NC_005966.1.

3D structure databases

ProteinModelPortaliQ59091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62977.ACIAD1705.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG68312; CAG68312; ACIAD1449.
CAG68547; CAG68547; ACIAD1705.
GeneIDi25684307.
KEGGiaci:ACIAD1449.
aci:ACIAD1705.
PATRICi20740708. VBIAciSp98416_1306.

Phylogenomic databases

eggNOGiENOG4107QNJ. Bacteria.
COG2057. LUCA.
HOGENOMiHOG000221245.
KOiK01032.
OMAiANWRVGS.
OrthoDBiPOG091H0D0N.

Enzyme and pathway databases

UniPathwayiUPA00157; UER00262.
BioCyciASP62977:GJVV-1376-MONOMER.
ASP62977:GJVV-1617-MONOMER.

Family and domain databases

InterProiIPR012791. 3-oxoacid_CoA-transf_B.
IPR004165. CoA_trans_fam_I.
IPR004164. CoA_transf_AS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02428. pcaJ_scoB_fam. 1 hit.
PROSITEiPS01274. COA_TRANSF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCAJ_ACIAD
AccessioniPrimary (citable) accession number: Q59091
Secondary accession number(s): Q43934
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 31, 2004
Last modified: September 7, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.