Q59087 (3DHQ_ACIAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catabolic 3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Gene names

Name:	quiB
Ordered Locus Names:	ACIAD1713

Organism

Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP]

Taxonomic identifier

62977 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the catabolic dehydration of dehydroquinate to dehydroshikimate. HAMAP MF_00214
Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2. HAMAP MF_00214
Induction	By protocatechuate. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.
Sequence caution	The sequence AAC37158.1 differs from that shown. Reason: Erroneous initiation. The sequence CAG68555.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Quinate metabolism
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	quinate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Catabolic 3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000138842
Sites
	Active site	163	1	Proton acceptor By similarity
	Active site	190	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59087 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: 98646DC5E88BF6D3	FASTA	272	29,899
	10 20 30 40 50 60 MSLPILSTTY AAENTVPASK STYVVKNLNI GDLPVKTLVP ITAKTREQAL AQAKVIAENK 70 80 90 100 110 120 DADIAEFRID LLEFASDTKK VIALGQELNQ ILKDKPLLAT IRTSNEGGKL KVTDQEYEKI 130 140 150 160 170 180 YSEYLKKPFM QLLDIEMFRD QAAVAKLTKL AHQKKVLVVM SNHDFDKTPS EQEIVSRLLK 190 200 210 220 230 240 QDQMGADILK IAVMPKSKQD VFTLMNATLK VSEQSTKPLL TMSMGRLGTI SRIATANMGG 250 260 270 SLSFGMIGEA SAPGQIDVTA LKQFLKTVQP TP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Unusual ancestry of dehydratases associated with quinate catabolism in Acinetobacter calcoaceticus." Elsemore D.A., Ornston L.N. J. Bacteriol. 177:5971-5978(1995) [PubMed: 7592351] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[2]	"Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ADP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L05770 Genomic DNA. Translation: AAC37158.1. Different initiation. CR543861 Genomic DNA. Translation: CAG68555.1. Different initiation.
RefSeq	YP_046377.1. NC_005966.1.
3D structure databases
ProteinModelPortal	Q59087.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59087.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2879575.
GenomeReviews	Gene locus ACIAD1713 in contig CR543861_GR.
KEGG	aci:ACIAD1713.
NMPDR	fig|62977.3.peg.1639.
PATRIC	20741196. VBIAciSp98416_1544.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0710.
HOGENOM	HBG732926.
PhylomeDB	Q59087.
ProtClustDB	PRK02412.
Enzyme and pathway databases
BioCyc	ASP62977:ACIAD1713-MONOMER. MetaCyc:MONOMER-33.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR018508. 3-dehydroquinate_DH_AS. IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

3DHQ_ACIAD

Accession

Primary (citable) accession number: Q59087
Secondary accession number(s): Q6FBK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program