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Q59049

- HPRT_METJA

UniProt

Q59049 - HPRT_METJA

Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

    Catalytic activityi

    IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
    GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
    2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. IMP salvage Source: UniProtKB-UniPathway
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    UniPathwayiUPA00591; UER00648.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
    Short name:
    HGPRTaseUniRule annotation
    Gene namesi
    Name:hptUniRule annotation
    Ordered Locus Names:MJ1655
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183Hypoxanthine/guanine phosphoribosyltransferasePRO_0000149496Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243232.MJ1655.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59049.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0503.
    KOiK00759.
    OMAiIATDIPY.
    PhylomeDBiQ59049.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01467. Hypx_phosphoribosyltr.
    InterProiIPR026597. HGPRTase-like.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59049-1 [UniParc]FASTAAdd to Basket

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    MLLEETLKSC PIVKRGEYHY FIHPISDGVP VVEPKLLREV ATRIIKIGDF    50
    EGATKLVTAE AMGIPLVTTL SLYTDIPYVI MRKREYKLPG EIPVFQSTGY 100
    SKGQLYLNGI EKGDKVVIID DVISTGGTMI AIIDALKRAG AEIKDIICVI 150
    ERGEGKKIVE EKTGYKIKTL VKIDVVDGKV VIL 183
    Length:183
    Mass (Da):20,218
    Last modified:November 1, 1997 - v1
    Checksum:iA20172DC74A941FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99676.1.
    PIRiE64506.
    RefSeqiNP_248665.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB99676; AAB99676; MJ_1655.
    GeneIDi1452564.
    KEGGimja:MJ_1655.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99676.1 .
    PIRi E64506.
    RefSeqi NP_248665.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q59049.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ1655.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB99676 ; AAB99676 ; MJ_1655 .
    GeneIDi 1452564.
    KEGGi mja:MJ_1655.

    Phylogenomic databases

    eggNOGi COG0503.
    KOi K00759.
    OMAi IATDIPY.
    PhylomeDBi Q59049.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00648 .

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01467. Hypx_phosphoribosyltr.
    InterProi IPR026597. HGPRTase-like.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

    Entry informationi

    Entry nameiHPRT_METJA
    AccessioniPrimary (citable) accession number: Q59049
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3