Reviewed,
UniProtKB/Swiss-Prot Q59024 (DP2L_METJA)
Last modified
July 22, 2008.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: DNA polymerase II large subunit Short name=Pol II EC=2.7.7.7 | ||||
| Gene names |
| ||||
| Organism | Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 2190 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus |
Protein attributes
| Sequence length | 1139 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. |
| Catalytic activity | Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates. |
| Subunit structure | Heterodimer of a large subunit and a small subunit. |
| Sequence similarities | Belongs to the archaeal DNA polymerase II family. |
Ontologies
Keywords | |
|---|---|
| Biological process | DNA replication |
| Ligand | DNA-binding |
| Molecular function | DNA-directed DNA polymerase Exonuclease Hydrolase Nuclease Nucleotidyltransferase Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
Gene Ontology (GO) | |
| Biological process | DNA catabolic process, exonucleolytic Inferred from electronic annotation. Source: HAMAP DNA-dependent DNA replicationInferred from electronic annotation. Source: HAMAP |
| Molecular function | 3'-5' exonuclease activity Inferred from electronic annotation. Source: HAMAP DNA bindingInferred from electronic annotation. Source: HAMAP DNA-directed DNA polymerase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 1139 | 1139 | DNA polymerase II large subunit | PRO_0000152575 | |||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. Venter J.C.Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440. |
| [2] | "A novel DNA polymerase family found in Archaea." Ishino Y., Komori K., Cann I.K.O., Koga Y. J. Bacteriol. 180:2232-2236(1998) [PubMed: 9555910] [Abstract] Cited for: CHARACTERIZATION. |
Cross-references
Sequence databases | |
|---|---|
| L77117 Genomic DNA. Translation: AAB99651.1. | |
| PIR | D64503. |
| RefSeq | NP_248640.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1452539. |
| GenomeReviews | Gene locus MJ1630 in contig L77117_GR. |
| KEGG | mja:MJ1630. |
| NMPDR | fig|243232.1.peg.1677. |
| TIGR | MJ1630. |
Phylogenomic databases | |
| HOGENOM | Q59024. |
Enzyme and pathway databases | |
| BioCyc | MJAN243232:MJ_1630-MON. |
Family and domain databases | |
| HAMAP | MF_00324. [Tree] |
| InterPro | IPR004475. PolC_DP2. IPR016033. PolC_DP2_N. [Graphical view] |
| Pfam | PF03833. PolC_DP2. 1 hit. [Graphical view] |
| PIRSF | PIRSF016275. PolC_DP2. 1 hit. |
| TIGRFAMs | TIGR00354. polC. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | DP2L_METJA | ||||||||
| Accession | Primary (citable) accession number: Q59024 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Methanococcus jannaschii Methanococcus jannaschii: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


