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Protein

Putative biotin ligase

Gene

MJ1619

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)].

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Biotin, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative biotin ligase (EC:6.3.4.15)
Gene namesi
Ordered Locus Names:MJ1619
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649821 – 237Putative biotin ligaseAdd BLAST237

Proteomic databases

PRIDEiQ59014.

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1619.

Structurei

Secondary structure

1237
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi12 – 21Combined sources10
Beta strandi26 – 32Combined sources7
Beta strandi34 – 36Combined sources3
Helixi40 – 42Combined sources3
Beta strandi51 – 59Combined sources9
Helixi65 – 80Combined sources16
Turni81 – 83Combined sources3
Beta strandi88 – 91Combined sources4
Turni92 – 94Combined sources3
Beta strandi95 – 100Combined sources6
Beta strandi103 – 114Combined sources12
Beta strandi116 – 125Combined sources10
Beta strandi127 – 129Combined sources3
Helixi133 – 137Combined sources5
Helixi142 – 146Combined sources5
Helixi152 – 171Combined sources20
Helixi177 – 187Combined sources11
Beta strandi188 – 190Combined sources3
Beta strandi194 – 199Combined sources6
Beta strandi204 – 212Combined sources9
Beta strandi214 – 221Combined sources8
Beta strandi224 – 229Combined sources6
Helixi230 – 232Combined sources3
Beta strandi233 – 236Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EJ9X-ray2.00A1-237[»]
ProteinModelPortaliQ59014.
SMRiQ59014.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ59014.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 191BPL/LPL catalyticPROSITE-ProRule annotationAdd BLAST191

Sequence similaritiesi

Belongs to the biotin--protein ligase family.Curated

Phylogenomic databases

eggNOGiarCOG01940. Archaea.
COG0340. LUCA.
InParanoidiQ59014.
KOiK03524.
OMAiRAAVWKH.
OrthoDBiPOG093Z0HWP.
PhylomeDBiQ59014.

Family and domain databases

CDDicd16442. BPL. 1 hit.
InterProiView protein in InterPro
IPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LPL_catalytic.
PANTHERiPTHR12835:SF5. PTHR12835:SF5. 1 hit.
PfamiView protein in Pfam
PF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
PROSITEiView protein in PROSITE
PS51733. BPL_LPL_CATALYTIC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIIHLSEID STNDYAKELA KEGKRNFIVL ADKQNNGKGR WGRVWYSDEG
60 70 80 90 100
GLYFSMVLDS KLYNPKVINL LVPICIIEVL KNYVDKELGL KFPNDIMVKV
110 120 130 140 150
NDNYKKLGGI LTELTDDYMI IGIGINVNNQ IRNEIREIAI SLKEITGKEL
160 170 180 190 200
DKVEILSNFL KTFESYLEKL KNKEIDDYEI LKKYKKYSIT IGKQVKILLS
210 220 230
NNEIITGKVY DIDFDGIVLG TEKGIERIPS GICIHVR
Length:237
Mass (Da):27,185
Last modified:November 1, 1996 - v1
Checksum:i602506218437B1F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99640.1.
PIRiB64502.
RefSeqiWP_010871144.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99640; AAB99640; MJ_1619.
GeneIDi1452528.
KEGGimja:MJ_1619.

Similar proteinsi

Entry informationi

Entry nameiBPL_METJA
AccessioniPrimary (citable) accession number: Q59014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families