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Protein

Putative biotin ligase

Gene

MJ1619

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)].

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Biotin, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative biotin ligase (EC:6.3.4.15)
Gene namesi
Ordered Locus Names:MJ1619
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Putative biotin ligasePRO_0000064982Add
BLAST

Proteomic databases

PRIDEiQ59014.

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1619.

Structurei

Secondary structure

1
237
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76Combined sources
Helixi12 – 2110Combined sources
Beta strandi26 – 327Combined sources
Beta strandi34 – 363Combined sources
Helixi40 – 423Combined sources
Beta strandi51 – 599Combined sources
Helixi65 – 8016Combined sources
Turni81 – 833Combined sources
Beta strandi88 – 914Combined sources
Turni92 – 943Combined sources
Beta strandi95 – 1006Combined sources
Beta strandi103 – 11412Combined sources
Beta strandi116 – 12510Combined sources
Beta strandi127 – 1293Combined sources
Helixi133 – 1375Combined sources
Helixi142 – 1465Combined sources
Helixi152 – 17120Combined sources
Helixi177 – 18711Combined sources
Beta strandi188 – 1903Combined sources
Beta strandi194 – 1996Combined sources
Beta strandi204 – 2129Combined sources
Beta strandi214 – 2218Combined sources
Beta strandi224 – 2296Combined sources
Helixi230 – 2323Combined sources
Beta strandi233 – 2364Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EJ9X-ray2.00A1-237[»]
ProteinModelPortaliQ59014.
SMRiQ59014. Positions 1-237.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ59014.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 191191BPL/LPL catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the biotin--protein ligase family.Curated
Contains 1 BPL/LPL catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG01940. Archaea.
COG0340. LUCA.
InParanoidiQ59014.
KOiK03524.
OMAiRLDRSWF.
PhylomeDBiQ59014.

Family and domain databases

InterProiIPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LPL_catalytic.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIIHLSEID STNDYAKELA KEGKRNFIVL ADKQNNGKGR WGRVWYSDEG
60 70 80 90 100
GLYFSMVLDS KLYNPKVINL LVPICIIEVL KNYVDKELGL KFPNDIMVKV
110 120 130 140 150
NDNYKKLGGI LTELTDDYMI IGIGINVNNQ IRNEIREIAI SLKEITGKEL
160 170 180 190 200
DKVEILSNFL KTFESYLEKL KNKEIDDYEI LKKYKKYSIT IGKQVKILLS
210 220 230
NNEIITGKVY DIDFDGIVLG TEKGIERIPS GICIHVR
Length:237
Mass (Da):27,185
Last modified:November 1, 1996 - v1
Checksum:i602506218437B1F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99640.1.
PIRiB64502.

Genome annotation databases

EnsemblBacteriaiAAB99640; AAB99640; MJ_1619.
KEGGimja:MJ_1619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99640.1.
PIRiB64502.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EJ9X-ray2.00A1-237[»]
ProteinModelPortaliQ59014.
SMRiQ59014. Positions 1-237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1619.

Proteomic databases

PRIDEiQ59014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99640; AAB99640; MJ_1619.
KEGGimja:MJ_1619.

Phylogenomic databases

eggNOGiarCOG01940. Archaea.
COG0340. LUCA.
InParanoidiQ59014.
KOiK03524.
OMAiRLDRSWF.
PhylomeDBiQ59014.

Miscellaneous databases

EvolutionaryTraceiQ59014.

Family and domain databases

InterProiIPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LPL_catalytic.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBPL_METJA
AccessioniPrimary (citable) accession number: Q59014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.