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Q59011

- IMDH_METJA

UniProt

Q59011 - IMDH_METJA

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Protein
Inosine-5'-monophosphate dehydrogenase
Gene
guaB, MJ1616
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei247 – 2471NAD By similarity
Metal bindingi301 – 3011Potassium; via carbonyl oxygen By similarity
Metal bindingi303 – 3031Potassium; via carbonyl oxygen By similarity
Binding sitei304 – 3041IMP By similarity
Active sitei306 – 3061Thioimidate intermediate By similarity
Metal bindingi306 – 3061Potassium; via carbonyl oxygen By similarity
Binding sitei423 – 4231IMP By similarity
Metal bindingi477 – 4771Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi478 – 4781Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi479 – 4791Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi299 – 3013NAD By similarity

GO - Molecular functioni

  1. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  2. adenyl nucleotide binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
Ordered Locus Names:MJ1616
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Inosine-5'-monophosphate dehydrogenaseUniRule annotation
PRO_0000093719Add
BLAST

Proteomic databases

PRIDEiQ59011.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243232.MJ1616.

Structurei

3D structure databases

ProteinModelPortaliQ59011.
SMRiQ59011. Positions 2-493.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 15257CBS 1
Add
BLAST
Domaini156 – 21257CBS 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni339 – 3413IMP binding By similarity
Regioni362 – 3632IMP binding By similarity
Regioni386 – 3905IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG0517.
KOiK00088.
OMAiHGHSKNI.
PhylomeDBiQ59011.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59011-1 [UniParc]FASTAAdd to Basket

« Hide

MFLKKLIEAK KAYTFDDVLL VPNASWVEPK DTDVSTDLAG LKLNIPIVSA    50
AMDTVTEKEM AIALARLGGL GVIHRNMSIE EQVHQVQAVK KADEVVIKDV 100
ITVSPDDTVG EAINVMETYS ISGLPVVDNE DKLVGIITHR DVKAIEDKTK 150
KVKDVMTKDV VCAKEDVEEE EALELMYANR VERLPIVDDE NRLIGIITLR 200
DILKRRKYPQ AARDKKGRLL VAAACGPHDF ERAKALIEAE VDAIAIDCAH 250
AHNMRVVENV KKFKEMLEGT DIKLIVGNIA TKEAAEDLIK AGADVLKVGI 300
GPGSICTTRV VAGVGVPQLT AVAEVADVAK EHNVPIIADG GIRYSGDIAK 350
AIAAGADAVM LGSLLAGTDE APGQLMVING RKYKQYRGMG SLGAMTGGVG 400
AGADRYFQAP AKSHMKHVKL VPEGVEGAVP YKGPVSEVVF QLIGGLRASM 450
GYCGAKNLKE MQEKARFVII TPSGQVESHP HDIIITNEAP NYPLGK 496
Length:496
Mass (Da):53,317
Last modified:November 1, 1997 - v1
Checksum:iC3E03FDDF3898396
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99638.1.
PIRiG64501.
RefSeqiNP_248626.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99638; AAB99638; MJ_1616.
GeneIDi1452525.
KEGGimja:MJ_1616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99638.1 .
PIRi G64501.
RefSeqi NP_248626.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q59011.
SMRi Q59011. Positions 2-493.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243232.MJ1616.

Proteomic databases

PRIDEi Q59011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99638 ; AAB99638 ; MJ_1616 .
GeneIDi 1452525.
KEGGi mja:MJ_1616.

Phylogenomic databases

eggNOGi COG0517.
KOi K00088.
OMAi HGHSKNI.
PhylomeDBi Q59011.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiIMDH_METJA
AccessioniPrimary (citable) accession number: Q59011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi