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Q59011

- IMDH_METJA

UniProt

Q59011 - IMDH_METJA

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Protein

Inosine-5'-monophosphate dehydrogenase

Gene

guaB

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei247 – 2471NADUniRule annotation
Metal bindingi301 – 3011Potassium; via carbonyl oxygenUniRule annotation
Metal bindingi303 – 3031Potassium; via carbonyl oxygenUniRule annotation
Binding sitei304 – 3041IMPUniRule annotation
Active sitei306 – 3061Thioimidate intermediateUniRule annotation
Metal bindingi306 – 3061Potassium; via carbonyl oxygenUniRule annotation
Binding sitei423 – 4231IMPUniRule annotation
Metal bindingi477 – 4771Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
Metal bindingi478 – 4781Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
Metal bindingi479 – 4791Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi299 – 3013NADUniRule annotation

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)
Short name:
IMP dehydrogenaseUniRule annotation
Short name:
IMPDUniRule annotation
Short name:
IMPDHUniRule annotation
Gene namesi
Name:guaBUniRule annotation
Ordered Locus Names:MJ1616
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Inosine-5'-monophosphate dehydrogenasePRO_0000093719Add
BLAST

Proteomic databases

PRIDEiQ59011.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi243232.MJ1616.

Structurei

3D structure databases

ProteinModelPortaliQ59011.
SMRiQ59011. Positions 2-493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 15257CBS 1UniRule annotationAdd
BLAST
Domaini156 – 21257CBS 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni339 – 3413IMP bindingUniRule annotation
Regioni362 – 3632IMP bindingUniRule annotation
Regioni386 – 3905IMP bindingUniRule annotation

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.UniRule annotation
Contains 2 CBS domains.UniRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG0517.
InParanoidiQ59011.
KOiK00088.
OMAiHGHSKNI.
PhylomeDBiQ59011.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59011-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLKKLIEAK KAYTFDDVLL VPNASWVEPK DTDVSTDLAG LKLNIPIVSA
60 70 80 90 100
AMDTVTEKEM AIALARLGGL GVIHRNMSIE EQVHQVQAVK KADEVVIKDV
110 120 130 140 150
ITVSPDDTVG EAINVMETYS ISGLPVVDNE DKLVGIITHR DVKAIEDKTK
160 170 180 190 200
KVKDVMTKDV VCAKEDVEEE EALELMYANR VERLPIVDDE NRLIGIITLR
210 220 230 240 250
DILKRRKYPQ AARDKKGRLL VAAACGPHDF ERAKALIEAE VDAIAIDCAH
260 270 280 290 300
AHNMRVVENV KKFKEMLEGT DIKLIVGNIA TKEAAEDLIK AGADVLKVGI
310 320 330 340 350
GPGSICTTRV VAGVGVPQLT AVAEVADVAK EHNVPIIADG GIRYSGDIAK
360 370 380 390 400
AIAAGADAVM LGSLLAGTDE APGQLMVING RKYKQYRGMG SLGAMTGGVG
410 420 430 440 450
AGADRYFQAP AKSHMKHVKL VPEGVEGAVP YKGPVSEVVF QLIGGLRASM
460 470 480 490
GYCGAKNLKE MQEKARFVII TPSGQVESHP HDIIITNEAP NYPLGK
Length:496
Mass (Da):53,317
Last modified:November 1, 1997 - v1
Checksum:iC3E03FDDF3898396
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99638.1.
PIRiG64501.
RefSeqiNP_248626.1. NC_000909.1.
WP_010871141.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99638; AAB99638; MJ_1616.
GeneIDi1452525.
KEGGimja:MJ_1616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99638.1 .
PIRi G64501.
RefSeqi NP_248626.1. NC_000909.1.
WP_010871141.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q59011.
SMRi Q59011. Positions 2-493.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1616.

Proteomic databases

PRIDEi Q59011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99638 ; AAB99638 ; MJ_1616 .
GeneIDi 1452525.
KEGGi mja:MJ_1616.

Phylogenomic databases

eggNOGi COG0517.
InParanoidi Q59011.
KOi K00088.
OMAi HGHSKNI.
PhylomeDBi Q59011.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiIMDH_METJA
AccessioniPrimary (citable) accession number: Q59011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3