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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1

Gene

apgM1

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.2 Publications

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.2 Publications

Cofactori

Mg2+1 Publication

Enzyme regulationi

Inhibited to approximately 20% by EDTA.1 Publication

pH dependencei

Optimum pH is 8.0.1 Publication

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.1 Publication
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (apgM2), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (apgM1)
  4. Enolase (eno)
  5. Pyruvate kinase (MJ0108)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-4905.
BRENDAi5.4.2.12. 3260.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (EC:5.4.2.12)
Short name:
BPG-independent PGAM 1
Short name:
Phosphoglyceromutase 1
Short name:
aPGAM 1
Alternative name(s):
aPGAM-Mj1
Gene namesi
Name:apgM1
Ordered Locus Names:MJ1612
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001381341 – 4112,3-bisphosphoglycerate-independent phosphoglycerate mutase 1Add BLAST411

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi243232.MJ_1612.

Structurei

3D structure databases

ProteinModelPortaliQ59007.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01696. Archaea.
COG3635. LUCA.
InParanoidiQ59007.
KOiK15635.
OMAiKDHSADP.
PhylomeDBiQ59007.

Family and domain databases

Gene3Di3.40.720.10. 2 hits.
HAMAPiMF_01402_A. ApgM_A. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR023665. ApgAM_prokaryotes.
IPR006124. Metalloenzyme.
IPR004456. Pglycerate_mutase_ApgM.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
PF10143. PhosphMutase. 1 hit.
[Graphical view]
PIRSFiPIRSF006392. IPGAM_arch. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR00306. apgM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59007-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKGKCVIFI IDGLGDRPNE KGLTPLKEAK TPTMDKIAKE GICGLMNAID
60 70 80 90 100
IGIRPGSDTA HLAILGYNPY EVYTGRGPLE AFGVGLDLKE GDIAFRCNFA
110 120 130 140 150
TVDENFVVLD RRAGRISPEE AEELEKEIDG LEIDGVKVIF KSSKGYRGAL
160 170 180 190 200
VLRGEGLSCR VSDGDPHEEG VKVSEIKPLD DSEEAKRTAE ILNKLLKIVY
210 220 230 240 250
EKLNNHPINE ERRKKGLPPA NIILPRGAGV VPKIEKFSEK YNMKGACICG
260 270 280 290 300
TGLIKGMAKM IGLDVIEVEG ATGTPKTNFM GKAKALVEAL KEYDFVLVNV
310 320 330 340 350
KGADEASHDG NYELKKEVLE KIDEMLAYVF EHINKDEVYF VLTGDHSTPI
360 370 380 390 400
EMKDHSADPI PIVIWGKSVR VDDVTEFNEF ACAKGALHWI KGEHVMKILL
410
DLTGRNEKFG A
Length:411
Mass (Da):45,226
Last modified:November 1, 1996 - v1
Checksum:i47A986FD09BA1099
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99632.1.
PIRiC64501.
RefSeqiWP_010871137.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99632; AAB99632; MJ_1612.
GeneIDi1452521.
KEGGimja:MJ_1612.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99632.1.
PIRiC64501.
RefSeqiWP_010871137.1. NC_000909.1.

3D structure databases

ProteinModelPortaliQ59007.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1612.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99632; AAB99632; MJ_1612.
GeneIDi1452521.
KEGGimja:MJ_1612.

Phylogenomic databases

eggNOGiarCOG01696. Archaea.
COG3635. LUCA.
InParanoidiQ59007.
KOiK15635.
OMAiKDHSADP.
PhylomeDBiQ59007.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciMetaCyc:MONOMER-4905.
BRENDAi5.4.2.12. 3260.

Family and domain databases

Gene3Di3.40.720.10. 2 hits.
HAMAPiMF_01402_A. ApgM_A. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR023665. ApgAM_prokaryotes.
IPR006124. Metalloenzyme.
IPR004456. Pglycerate_mutase_ApgM.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
PF10143. PhosphMutase. 1 hit.
[Graphical view]
PIRSFiPIRSF006392. IPGAM_arch. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR00306. apgM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPGM1_METJA
AccessioniPrimary (citable) accession number: Q59007
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.