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Protein

Adhesion G-protein coupled receptor F3

Gene

ADGRF3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.035.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor F3
Alternative name(s):
G-protein coupled receptor 113
G-protein coupled receptor PGR23
Gene namesi
Name:ADGRF3
Synonyms:Gm1041, Gpr113, Pcr113, Pgr23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2685887. Adgrf3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 694ExtracellularCuratedAdd BLAST674
Transmembranei695 – 715Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini716 – 730CytoplasmicCuratedAdd BLAST15
Transmembranei731 – 751Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini752 – 757ExtracellularCurated6
Transmembranei758 – 778Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini779 – 799CytoplasmicCuratedAdd BLAST21
Transmembranei800 – 820Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini821 – 850ExtracellularCuratedAdd BLAST30
Transmembranei851 – 871Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini872 – 892CytoplasmicCuratedAdd BLAST21
Transmembranei893 – 913Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini914 – 916ExtracellularCurated3
Transmembranei917 – 937Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini938 – 991CytoplasmicCuratedAdd BLAST54

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000030530521 – 991Adhesion G-protein coupled receptor F3Add BLAST971

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1
Glycosylationi484N-linked (GlcNAc...)Sequence analysis1
Glycosylationi571N-linked (GlcNAc...)Sequence analysis1
Glycosylationi589N-linked (GlcNAc...)Sequence analysis1
Glycosylationi630N-linked (GlcNAc...)Sequence analysis1
Glycosylationi660N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ58Y75.
PRIDEiQ58Y75.

PTM databases

PhosphoSitePlusiQ58Y75.

Expressioni

Tissue specificityi

Expression is restricted to testis and circumvallate papillae.1 Publication

Gene expression databases

BgeeiENSMUSG00000067642.
CleanExiMM_GPR113.
ExpressionAtlasiQ58Y75. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110422.

Structurei

3D structure databases

ProteinModelPortaliQ58Y75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini632 – 683GPSPROSITE-ProRule annotationAdd BLAST52

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128272.
HOGENOMiHOG000112763.
HOVERGENiHBG051770.
InParanoidiQ58Y75.
KOiK08456.
OMAiWNVTKAG.
OrthoDBiEOG091G022O.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58Y75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLALSQLL LAVTLPLLEL EPTFVPTAQS ELSPYGGKSG QQLNQYSGEG
60 70 80 90 100
ESVLVSSYVH LEFSSTAWPQ ELSKNFTLPT ALAVLPPKTL TGLGLTTECR
110 120 130 140 150
ANHSGTSLCT CHPGYQWNAT LCSLYPHCWG RRSERDSCMC RSFHGPVTGY
160 170 180 190 200
CQLLPPVPAN LILDSQLQMH GNTLNLILLK KEEATNLRWF LRHSKNHTPI
210 220 230 240 250
SLWPGTNVLQ TSSEGQSGLR VARMSRHWAG EYESIFEAQG FRWRLRQLVK
260 270 280 290 300
VPLQEEEVVR LPDALSISCT ASTGFQLSCC IPLTTDYTAT WSPGEDSQAS
310 320 330 340 350
LQKMSDSQCF VLAVPHCPAT NTTYTCTLQS QNLPPLVAPV SITIIQDGDT
360 370 380 390 400
TCPEDFSVVS WNVTKAGFVA QAPCPVNKKG VVKRLCGTDG IWRPVQNTCT
410 420 430 440 450
EAKILTLCLK AKLLEGQGKP YEEVPWILSE LQEQVGVAST PSDLWEMLHT
460 470 480 490 500
VTLLAKVVAE TSTELTGSAL KDLLTTTDKI LDANISALWT LAQAQEPSMG
510 520 530 540 550
SDFLKAVETL VHSLRPQQHP FSFSSANVLL QSQLLRHSSP PGYQMSFSTW
560 570 580 590 600
PLLQARIPWH SLAPLVHSGT NVSITSLVLQ KLDYRLPSNY TQGLWNTPYT
610 620 630 640 650
TPGLILVVSI TADGQAFTQA EVIMDYEDMN GTLHCVFWDH RVFQGQGGWS
660 670 680 690 700
DEGCEVHAAN ASITQCICQH LTAFSILMSQ HTVPENPTLD LLSQVGTGAS
710 720 730 740 750
VLALLVCLAI YGLVWRVVVR NKVAFFRHTT LFNMVICLLV ADTCFLGSPF
760 770 780 790 800
LPSGYHSLIC LVTAFLCHFF YLATFFWMLA QALVLAHQLL FVFHQLSKHV
810 820 830 840 850
VLSLMVMLGY LCPLGFAGVT LGLYLPQRKY LWEGKCFLNG GGVMLYSFSE
860 870 880 890 900
PVLAIVGVNG LVLVIAVLKL LRPSLSEGPT VEKRQALVGV LKALLILTPI
910 920 930 940 950
FGLTWGLGVA TLFDGSIVSH YAFSILNSLQ GVFILVFGCL TDKKVLEALR
960 970 980 990
KRLRGSRSSN SAISMVTNET YTSEHSKERS EPASYEERMT D
Length:991
Mass (Da):108,975
Last modified:October 3, 2012 - v2
Checksum:i42D708F49225A4F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201S → G in AAW23327 (PubMed:15780750).Curated1
Sequence conflicti455A → T in AAW23327 (PubMed:15780750).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY701869 mRNA. Translation: AAW23327.1.
AC158757 Genomic DNA. No translation available.
AY255593 mRNA. Translation: AAO85105.1.
CCDSiCCDS51450.1.
RefSeqiNP_001014416.2. NM_001014394.2.
UniGeneiMm.291148.

Genome annotation databases

EnsembliENSMUST00000088117; ENSMUSP00000085440; ENSMUSG00000067642.
GeneIDi381628.
KEGGimmu:381628.
UCSCiuc008wvg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY701869 mRNA. Translation: AAW23327.1.
AC158757 Genomic DNA. No translation available.
AY255593 mRNA. Translation: AAO85105.1.
CCDSiCCDS51450.1.
RefSeqiNP_001014416.2. NM_001014394.2.
UniGeneiMm.291148.

3D structure databases

ProteinModelPortaliQ58Y75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110422.

Protein family/group databases

MEROPSiP02.035.
GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ58Y75.

Proteomic databases

PaxDbiQ58Y75.
PRIDEiQ58Y75.

Protocols and materials databases

DNASUi381628.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088117; ENSMUSP00000085440; ENSMUSG00000067642.
GeneIDi381628.
KEGGimmu:381628.
UCSCiuc008wvg.1. mouse.

Organism-specific databases

CTDi165082.
MGIiMGI:2685887. Adgrf3.

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128272.
HOGENOMiHOG000112763.
HOVERGENiHBG051770.
InParanoidiQ58Y75.
KOiK08456.
OMAiWNVTKAG.
OrthoDBiEOG091G022O.

Miscellaneous databases

PROiQ58Y75.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067642.
CleanExiMM_GPR113.
ExpressionAtlasiQ58Y75. baseline and differential.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRF3_MOUSE
AccessioniPrimary (citable) accession number: Q58Y75
Secondary accession number(s): F8VPU1, Q80T50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.