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Protein

DDB1- and CUL4-associated factor 6

Gene

DCAF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.3 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • protein ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ58WW2.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 6
Alternative name(s):
Androgen receptor complex-associated protein
Short name:
ARCAP
IQ motif and WD repeat-containing protein 1
Nuclear receptor interaction protein
Short name:
NRIP
Gene namesi
Name:DCAF6
Synonyms:IQWD1
ORF Names:MSTP055
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30002. DCAF6.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
  • cytoplasm Source: HPA
  • focal adhesion Source: HPA
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55827.
OpenTargetsiENSG00000143164.
PharmGKBiPA165751150.

Polymorphism and mutation databases

BioMutaiDCAF6.
DMDMi74755134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003044011 – 860DDB1- and CUL4-associated factor 6Add BLAST860

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei654PhosphothreonineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei847PhosphoserineBy similarity1
Modified residuei850PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ58WW2.
MaxQBiQ58WW2.
PaxDbiQ58WW2.
PeptideAtlasiQ58WW2.
PRIDEiQ58WW2.

PTM databases

iPTMnetiQ58WW2.
PhosphoSitePlusiQ58WW2.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland.1 Publication

Gene expression databases

BgeeiENSG00000143164.
CleanExiHS_IQWD1.
ExpressionAtlasiQ58WW2. baseline and differential.
GenevisibleiQ58WW2. HS.

Organism-specific databases

HPAiHPA054305.

Interactioni

Subunit structurei

Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B.2 Publications

Protein-protein interaction databases

BioGridi120933. 34 interactors.
DIPiDIP-44678N.
IntActiQ58WW2. 12 interactors.
STRINGi9606.ENSP00000356814.

Structurei

Secondary structure

1860
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 18Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I7OX-ray2.80B9-21[»]
ProteinModelPortaliQ58WW2.
SMRiQ58WW2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58WW2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati49 – 88WD 1Add BLAST40
Repeati92 – 133WD 2Add BLAST42
Repeati139 – 179WD 3Add BLAST41
Repeati189 – 229WD 4Add BLAST41
Repeati251 – 290WD 5Add BLAST40
Domaini676 – 705IQPROSITE-ProRule annotationAdd BLAST30
Repeati718 – 756WD 6Add BLAST39
Repeati759 – 798WD 7Add BLAST40

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XQZP. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000038027.
HOVERGENiHBG054871.
InParanoidiQ58WW2.
KOiK11795.
OMAiFWGNNFV.
OrthoDBiEOG091G01Z0.
PhylomeDBiQ58WW2.
TreeFamiTF326071.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q58WW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRGGSYPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH
60 70 80 90 100
DGCVNTICWN DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA
110 120 130 140 150
KFLPCTNDKQ IVSCSGDGVI FYTNVEQDAE TNRQCQFTCH YGTTYEIMTV
160 170 180 190 200
PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE DCKDDILINC RRAATSVAIC
210 220 230 240 250
PPIPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM VARFIPSHLN
260 270 280 290 300
NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE
310 320 330 340 350
ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS
360 370 380 390 400
RWFEEASEVA QSNRGRGRSR PRGGTSQSDI STLPTVPSSP DLEVSETAME
410 420 430 440 450
VDTPAEQFLQ PSTSSTMSAQ AHSTSSPTES PHSTPLLSSP DSEQRQSVEA
460 470 480 490 500
SGHHTHHQSD NNNEKLSPKP GTGEPVLSLH YSTEGTTTST IKLNFTDEWS
510 520 530 540 550
SIASSSRGIG SHCKSEGQEE SFVPQSSVQP PEGDSETKAP EESSEDVTKY
560 570 580 590 600
QEGVSAENPV ENHINITQSD KFTAKPLDSN SGERNDLNLD RSCGVPEESA
610 620 630 640 650
SSEKAKEPET SDQTSTESAT NENNTNPEPQ FQTEATGPSA HEETSTRDSA
660 670 680 690 700
LQDTDDSDDD PVLIPGARYR AGPGDRRSAV ARIQEFFRRR KERKEMEELD
710 720 730 740 750
TLNIRRPLVK MVYKGHRNSR TMIKEANFWG ANFVMSGSDC GHIFIWDRHT
760 770 780 790 800
AEHLMLLEAD NHVVNCLQPH PFDPILASSG IDYDIKIWSP LEESRIFNRK
810 820 830 840 850
LADEVITRNE LMLEETRNTI TVPASFMLRM LASLNHIRAD RLEGDRSEGS
860
GQENENEDEE
Length:860
Mass (Da):96,292
Last modified:April 26, 2005 - v1
Checksum:i8C7602D635DAF124
GO
Isoform 2 (identifier: Q58WW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: S → SDSPSSVVNKQLGSMSLDEQQ

Note: No experimental confirmation available.
Show »
Length:880
Mass (Da):98,423
Checksum:i3CB84C1FBB647E0D
GO
Isoform 3 (identifier: Q58WW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: S → SEFLRGPEIA...LGSMSLDEQQ
     675-675: D → DRFNIRGTTIGDRIM

Show »
Length:951
Mass (Da):106,542
Checksum:iA60EC942B9C5035A
GO
Isoform 4 (identifier: Q58WW2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-84: Missing.
     459-459: S → SEFLRGPEIA...LGSMSLDEQQ
     675-675: D → DRFNIRGTTIGDRIM

Note: No experimental confirmation available.
Show »
Length:920
Mass (Da):103,070
Checksum:i30564F36EFA28122
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035020547V → A.1 PublicationCorresponds to variant rs11558511dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04331254 – 84Missing in isoform 4. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_028019459S → SDSPSSVVNKQLGSMSLDEQ Q in isoform 2. 1 Publication1
Alternative sequenceiVSP_028020459S → SEFLRGPEIALLRKRLQQLR LKKAEQQRQQELAAHTQQQP STSDQSSHEGSSQDPHASDS PSSVVNKQLGSMSLDEQQ in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_028021675D → DRFNIRGTTIGDRIM in isoform 3 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY766164 mRNA. Translation: AAX09330.1.
DQ768089 mRNA. Translation: ABG76793.1.
AF116725 mRNA. Translation: AAO15301.1.
AK297847 mRNA. Translation: BAG60180.1.
Z97876
, AL031287, AL033531, AL033532 Genomic DNA. Translation: CAI20078.1.
AL033531
, AL031287, AL033532, Z97876 Genomic DNA. Translation: CAI22478.1.
AL031287
, AL033531, AL033532, Z97876 Genomic DNA. Translation: CAI22481.1.
AL033532
, AL031287, AL033531, Z97876 Genomic DNA. Translation: CAI22625.1.
Z97876
, AL031287, AL033531, AL033532 Genomic DNA. Translation: CAM28213.1.
AL033531
, AL031287, AL033532, Z97876 Genomic DNA. Translation: CAM28292.1.
AL031287
, AL033531, AL033532, Z97876 Genomic DNA. Translation: CAM28293.1.
AL033532
, AL031287, AL033531, Z97876 Genomic DNA. Translation: CAM28303.1.
CH471067 Genomic DNA. Translation: EAW90809.1.
BC025262 mRNA. Translation: AAH25262.2.
AL136738 mRNA. Translation: CAB66672.2.
CCDSiCCDS1267.2. [Q58WW2-2]
CCDS30933.1. [Q58WW2-1]
CCDS55657.1. [Q58WW2-3]
CCDS55658.1. [Q58WW2-4]
RefSeqiNP_001017977.1. NM_001017977.2. [Q58WW2-1]
NP_001185885.1. NM_001198956.1. [Q58WW2-3]
NP_001185886.1. NM_001198957.1. [Q58WW2-4]
NP_060912.2. NM_018442.3. [Q58WW2-2]
UniGeneiHs.435741.

Genome annotation databases

EnsembliENST00000312263; ENSP00000311949; ENSG00000143164. [Q58WW2-1]
ENST00000367840; ENSP00000356814; ENSG00000143164. [Q58WW2-3]
ENST00000367843; ENSP00000356817; ENSG00000143164. [Q58WW2-2]
ENST00000432587; ENSP00000396238; ENSG00000143164. [Q58WW2-4]
GeneIDi55827.
KEGGihsa:55827.
UCSCiuc001gev.5. human. [Q58WW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY766164 mRNA. Translation: AAX09330.1.
DQ768089 mRNA. Translation: ABG76793.1.
AF116725 mRNA. Translation: AAO15301.1.
AK297847 mRNA. Translation: BAG60180.1.
Z97876
, AL031287, AL033531, AL033532 Genomic DNA. Translation: CAI20078.1.
AL033531
, AL031287, AL033532, Z97876 Genomic DNA. Translation: CAI22478.1.
AL031287
, AL033531, AL033532, Z97876 Genomic DNA. Translation: CAI22481.1.
AL033532
, AL031287, AL033531, Z97876 Genomic DNA. Translation: CAI22625.1.
Z97876
, AL031287, AL033531, AL033532 Genomic DNA. Translation: CAM28213.1.
AL033531
, AL031287, AL033532, Z97876 Genomic DNA. Translation: CAM28292.1.
AL031287
, AL033531, AL033532, Z97876 Genomic DNA. Translation: CAM28293.1.
AL033532
, AL031287, AL033531, Z97876 Genomic DNA. Translation: CAM28303.1.
CH471067 Genomic DNA. Translation: EAW90809.1.
BC025262 mRNA. Translation: AAH25262.2.
AL136738 mRNA. Translation: CAB66672.2.
CCDSiCCDS1267.2. [Q58WW2-2]
CCDS30933.1. [Q58WW2-1]
CCDS55657.1. [Q58WW2-3]
CCDS55658.1. [Q58WW2-4]
RefSeqiNP_001017977.1. NM_001017977.2. [Q58WW2-1]
NP_001185885.1. NM_001198956.1. [Q58WW2-3]
NP_001185886.1. NM_001198957.1. [Q58WW2-4]
NP_060912.2. NM_018442.3. [Q58WW2-2]
UniGeneiHs.435741.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I7OX-ray2.80B9-21[»]
ProteinModelPortaliQ58WW2.
SMRiQ58WW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120933. 34 interactors.
DIPiDIP-44678N.
IntActiQ58WW2. 12 interactors.
STRINGi9606.ENSP00000356814.

PTM databases

iPTMnetiQ58WW2.
PhosphoSitePlusiQ58WW2.

Polymorphism and mutation databases

BioMutaiDCAF6.
DMDMi74755134.

Proteomic databases

EPDiQ58WW2.
MaxQBiQ58WW2.
PaxDbiQ58WW2.
PeptideAtlasiQ58WW2.
PRIDEiQ58WW2.

Protocols and materials databases

DNASUi55827.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312263; ENSP00000311949; ENSG00000143164. [Q58WW2-1]
ENST00000367840; ENSP00000356814; ENSG00000143164. [Q58WW2-3]
ENST00000367843; ENSP00000356817; ENSG00000143164. [Q58WW2-2]
ENST00000432587; ENSP00000396238; ENSG00000143164. [Q58WW2-4]
GeneIDi55827.
KEGGihsa:55827.
UCSCiuc001gev.5. human. [Q58WW2-1]

Organism-specific databases

CTDi55827.
DisGeNETi55827.
GeneCardsiDCAF6.
HGNCiHGNC:30002. DCAF6.
HPAiHPA054305.
MIMi610494. gene.
neXtProtiNX_Q58WW2.
OpenTargetsiENSG00000143164.
PharmGKBiPA165751150.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XQZP. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000038027.
HOVERGENiHBG054871.
InParanoidiQ58WW2.
KOiK11795.
OMAiFWGNNFV.
OrthoDBiEOG091G01Z0.
PhylomeDBiQ58WW2.
TreeFamiTF326071.

Enzyme and pathway databases

UniPathwayiUPA00143.
SignaLinkiQ58WW2.

Miscellaneous databases

ChiTaRSiDCAF6. human.
EvolutionaryTraceiQ58WW2.
GenomeRNAii55827.
PROiQ58WW2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143164.
CleanExiHS_IQWD1.
ExpressionAtlasiQ58WW2. baseline and differential.
GenevisibleiQ58WW2. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCAF6_HUMAN
AccessioniPrimary (citable) accession number: Q58WW2
Secondary accession number(s): A2A295
, B4DNB8, Q7L8I0, Q8IXH3, Q8TB19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.