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Protein

DDB1- and CUL4-associated factor 6

Gene

DCAF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.3 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • protein ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ58WW2.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 6
Alternative name(s):
Androgen receptor complex-associated protein
Short name:
ARCAP
IQ motif and WD repeat-containing protein 1
Nuclear receptor interaction protein
Short name:
NRIP
Gene namesi
Name:DCAF6
Synonyms:IQWD1
ORF Names:MSTP055
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30002. DCAF6.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
  • cytoplasm Source: HPA
  • focal adhesion Source: HPA
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165751150.

Polymorphism and mutation databases

BioMutaiDCAF6.
DMDMi74755134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860DDB1- and CUL4-associated factor 6PRO_0000304401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei336 – 3361PhosphoserineCombined sources
Modified residuei649 – 6491PhosphoserineCombined sources
Modified residuei654 – 6541PhosphothreonineCombined sources
Modified residuei657 – 6571PhosphoserineCombined sources
Modified residuei847 – 8471PhosphoserineBy similarity
Modified residuei850 – 8501PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ58WW2.
MaxQBiQ58WW2.
PaxDbiQ58WW2.
PeptideAtlasiQ58WW2.
PRIDEiQ58WW2.

PTM databases

iPTMnetiQ58WW2.
PhosphoSiteiQ58WW2.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland.1 Publication

Gene expression databases

BgeeiQ58WW2.
CleanExiHS_IQWD1.
ExpressionAtlasiQ58WW2. baseline and differential.
GenevisibleiQ58WW2. HS.

Interactioni

Subunit structurei

Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B.2 Publications

Protein-protein interaction databases

BioGridi120933. 34 interactions.
DIPiDIP-44678N.
IntActiQ58WW2. 11 interactions.
STRINGi9606.ENSP00000356814.

Structurei

Secondary structure

1
860
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 189Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I7OX-ray2.80B9-21[»]
ProteinModelPortaliQ58WW2.
SMRiQ58WW2. Positions 42-222, 249-285, 723-790.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58WW2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati49 – 8840WD 1Add
BLAST
Repeati92 – 13342WD 2Add
BLAST
Repeati139 – 17941WD 3Add
BLAST
Repeati189 – 22941WD 4Add
BLAST
Repeati251 – 29040WD 5Add
BLAST
Domaini676 – 70530IQPROSITE-ProRule annotationAdd
BLAST
Repeati718 – 75639WD 6Add
BLAST
Repeati759 – 79840WD 7Add
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XQZP. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000038027.
HOVERGENiHBG054871.
InParanoidiQ58WW2.
KOiK11795.
OMAiFWGNNFV.
OrthoDBiEOG7P5T0B.
PhylomeDBiQ58WW2.
TreeFamiTF326071.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q58WW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRGGSYPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH
60 70 80 90 100
DGCVNTICWN DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA
110 120 130 140 150
KFLPCTNDKQ IVSCSGDGVI FYTNVEQDAE TNRQCQFTCH YGTTYEIMTV
160 170 180 190 200
PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE DCKDDILINC RRAATSVAIC
210 220 230 240 250
PPIPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM VARFIPSHLN
260 270 280 290 300
NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE
310 320 330 340 350
ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS
360 370 380 390 400
RWFEEASEVA QSNRGRGRSR PRGGTSQSDI STLPTVPSSP DLEVSETAME
410 420 430 440 450
VDTPAEQFLQ PSTSSTMSAQ AHSTSSPTES PHSTPLLSSP DSEQRQSVEA
460 470 480 490 500
SGHHTHHQSD NNNEKLSPKP GTGEPVLSLH YSTEGTTTST IKLNFTDEWS
510 520 530 540 550
SIASSSRGIG SHCKSEGQEE SFVPQSSVQP PEGDSETKAP EESSEDVTKY
560 570 580 590 600
QEGVSAENPV ENHINITQSD KFTAKPLDSN SGERNDLNLD RSCGVPEESA
610 620 630 640 650
SSEKAKEPET SDQTSTESAT NENNTNPEPQ FQTEATGPSA HEETSTRDSA
660 670 680 690 700
LQDTDDSDDD PVLIPGARYR AGPGDRRSAV ARIQEFFRRR KERKEMEELD
710 720 730 740 750
TLNIRRPLVK MVYKGHRNSR TMIKEANFWG ANFVMSGSDC GHIFIWDRHT
760 770 780 790 800
AEHLMLLEAD NHVVNCLQPH PFDPILASSG IDYDIKIWSP LEESRIFNRK
810 820 830 840 850
LADEVITRNE LMLEETRNTI TVPASFMLRM LASLNHIRAD RLEGDRSEGS
860
GQENENEDEE
Length:860
Mass (Da):96,292
Last modified:April 26, 2005 - v1
Checksum:i8C7602D635DAF124
GO
Isoform 2 (identifier: Q58WW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: S → SDSPSSVVNKQLGSMSLDEQQ

Note: No experimental confirmation available.
Show »
Length:880
Mass (Da):98,423
Checksum:i3CB84C1FBB647E0D
GO
Isoform 3 (identifier: Q58WW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-459: S → SEFLRGPEIA...LGSMSLDEQQ
     675-675: D → DRFNIRGTTIGDRIM

Show »
Length:951
Mass (Da):106,542
Checksum:iA60EC942B9C5035A
GO
Isoform 4 (identifier: Q58WW2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-84: Missing.
     459-459: S → SEFLRGPEIA...LGSMSLDEQQ
     675-675: D → DRFNIRGTTIGDRIM

Note: No experimental confirmation available.
Show »
Length:920
Mass (Da):103,070
Checksum:i30564F36EFA28122
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti547 – 5471V → A.1 Publication
Corresponds to variant rs11558511 [ dbSNP | Ensembl ].
VAR_035020

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei54 – 8431Missing in isoform 4. 1 PublicationVSP_043312Add
BLAST
Alternative sequencei459 – 4591S → SDSPSSVVNKQLGSMSLDEQ Q in isoform 2. 1 PublicationVSP_028019
Alternative sequencei459 – 4591S → SEFLRGPEIALLRKRLQQLR LKKAEQQRQQELAAHTQQQP STSDQSSHEGSSQDPHASDS PSSVVNKQLGSMSLDEQQ in isoform 3 and isoform 4. 2 PublicationsVSP_028020
Alternative sequencei675 – 6751D → DRFNIRGTTIGDRIM in isoform 3 and isoform 4. 2 PublicationsVSP_028021

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY766164 mRNA. Translation: AAX09330.1.
DQ768089 mRNA. Translation: ABG76793.1.
AF116725 mRNA. Translation: AAO15301.1.
AK297847 mRNA. Translation: BAG60180.1.
Z97876
, AL031287, AL033531, AL033532 Genomic DNA. Translation: CAI20078.1.
AL033531
, AL031287, AL033532, Z97876 Genomic DNA. Translation: CAI22478.1.
AL031287
, AL033531, AL033532, Z97876 Genomic DNA. Translation: CAI22481.1.
AL033532
, AL031287, AL033531, Z97876 Genomic DNA. Translation: CAI22625.1.
Z97876
, AL031287, AL033531, AL033532 Genomic DNA. Translation: CAM28213.1.
AL033531
, AL031287, AL033532, Z97876 Genomic DNA. Translation: CAM28292.1.
AL031287
, AL033531, AL033532, Z97876 Genomic DNA. Translation: CAM28293.1.
AL033532
, AL031287, AL033531, Z97876 Genomic DNA. Translation: CAM28303.1.
CH471067 Genomic DNA. Translation: EAW90809.1.
BC025262 mRNA. Translation: AAH25262.2.
AL136738 mRNA. Translation: CAB66672.2.
CCDSiCCDS1267.2. [Q58WW2-2]
CCDS30933.1. [Q58WW2-1]
CCDS55657.1. [Q58WW2-3]
CCDS55658.1. [Q58WW2-4]
RefSeqiNP_001017977.1. NM_001017977.2. [Q58WW2-1]
NP_001185885.1. NM_001198956.1. [Q58WW2-3]
NP_001185886.1. NM_001198957.1. [Q58WW2-4]
NP_060912.2. NM_018442.3. [Q58WW2-2]
UniGeneiHs.435741.

Genome annotation databases

EnsembliENST00000312263; ENSP00000311949; ENSG00000143164. [Q58WW2-1]
ENST00000367840; ENSP00000356814; ENSG00000143164. [Q58WW2-3]
ENST00000367843; ENSP00000356817; ENSG00000143164. [Q58WW2-2]
ENST00000432587; ENSP00000396238; ENSG00000143164. [Q58WW2-4]
GeneIDi55827.
KEGGihsa:55827.
UCSCiuc001gev.5. human. [Q58WW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY766164 mRNA. Translation: AAX09330.1.
DQ768089 mRNA. Translation: ABG76793.1.
AF116725 mRNA. Translation: AAO15301.1.
AK297847 mRNA. Translation: BAG60180.1.
Z97876
, AL031287, AL033531, AL033532 Genomic DNA. Translation: CAI20078.1.
AL033531
, AL031287, AL033532, Z97876 Genomic DNA. Translation: CAI22478.1.
AL031287
, AL033531, AL033532, Z97876 Genomic DNA. Translation: CAI22481.1.
AL033532
, AL031287, AL033531, Z97876 Genomic DNA. Translation: CAI22625.1.
Z97876
, AL031287, AL033531, AL033532 Genomic DNA. Translation: CAM28213.1.
AL033531
, AL031287, AL033532, Z97876 Genomic DNA. Translation: CAM28292.1.
AL031287
, AL033531, AL033532, Z97876 Genomic DNA. Translation: CAM28293.1.
AL033532
, AL031287, AL033531, Z97876 Genomic DNA. Translation: CAM28303.1.
CH471067 Genomic DNA. Translation: EAW90809.1.
BC025262 mRNA. Translation: AAH25262.2.
AL136738 mRNA. Translation: CAB66672.2.
CCDSiCCDS1267.2. [Q58WW2-2]
CCDS30933.1. [Q58WW2-1]
CCDS55657.1. [Q58WW2-3]
CCDS55658.1. [Q58WW2-4]
RefSeqiNP_001017977.1. NM_001017977.2. [Q58WW2-1]
NP_001185885.1. NM_001198956.1. [Q58WW2-3]
NP_001185886.1. NM_001198957.1. [Q58WW2-4]
NP_060912.2. NM_018442.3. [Q58WW2-2]
UniGeneiHs.435741.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I7OX-ray2.80B9-21[»]
ProteinModelPortaliQ58WW2.
SMRiQ58WW2. Positions 42-222, 249-285, 723-790.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120933. 34 interactions.
DIPiDIP-44678N.
IntActiQ58WW2. 11 interactions.
STRINGi9606.ENSP00000356814.

PTM databases

iPTMnetiQ58WW2.
PhosphoSiteiQ58WW2.

Polymorphism and mutation databases

BioMutaiDCAF6.
DMDMi74755134.

Proteomic databases

EPDiQ58WW2.
MaxQBiQ58WW2.
PaxDbiQ58WW2.
PeptideAtlasiQ58WW2.
PRIDEiQ58WW2.

Protocols and materials databases

DNASUi55827.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312263; ENSP00000311949; ENSG00000143164. [Q58WW2-1]
ENST00000367840; ENSP00000356814; ENSG00000143164. [Q58WW2-3]
ENST00000367843; ENSP00000356817; ENSG00000143164. [Q58WW2-2]
ENST00000432587; ENSP00000396238; ENSG00000143164. [Q58WW2-4]
GeneIDi55827.
KEGGihsa:55827.
UCSCiuc001gev.5. human. [Q58WW2-1]

Organism-specific databases

CTDi55827.
GeneCardsiDCAF6.
HGNCiHGNC:30002. DCAF6.
MIMi610494. gene.
neXtProtiNX_Q58WW2.
PharmGKBiPA165751150.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XQZP. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000038027.
HOVERGENiHBG054871.
InParanoidiQ58WW2.
KOiK11795.
OMAiFWGNNFV.
OrthoDBiEOG7P5T0B.
PhylomeDBiQ58WW2.
TreeFamiTF326071.

Enzyme and pathway databases

UniPathwayiUPA00143.
SignaLinkiQ58WW2.

Miscellaneous databases

ChiTaRSiDCAF6. human.
EvolutionaryTraceiQ58WW2.
GenomeRNAii55827.
PROiQ58WW2.
SOURCEiSearch...

Gene expression databases

BgeeiQ58WW2.
CleanExiHS_IQWD1.
ExpressionAtlasiQ58WW2. baseline and differential.
GenevisibleiQ58WW2. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NRIP, a novel nuclear receptor interaction protein, enhances the transcriptional activity of nuclear receptors."
    Tsai T.C., Lee Y.L., Hsiao W.C., Tsao Y.P., Chen S.L.
    J. Biol. Chem. 280:20000-20009(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH NR3C1 AND AR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "ARCAP, a novel androgen receptor coactivator, modulates the proliferation of hepatoma cells."
    Chang T.-J., Lui W.-Y., Hsia C.-Y., Huang K.-T., Huang M.-H., Lai C., King K.-L., Chau G.-Y., Chi C.-W., Li A.F.-Y.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Heart.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Heart.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 329-860 (ISOFORM 1), VARIANT ALA-547.
    Tissue: B-cell.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 355-860 (ISOFORM 2).
    Tissue: Testis.
  9. "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1."
    Jin J., Arias E.E., Chen J., Harper J.W., Walter J.C.
    Mol. Cell 23:709-721(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DDB1; CUL4A AND CUL4B, IDENTIFICATION BY MASS SPECTROMETRY.
  10. "Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery."
    Angers S., Li T., Yi X., MacCoss M.J., Moon R.T., Zheng N.
    Nature 443:590-593(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336 AND SER-657, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336 AND SER-657, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336; SER-649; THR-654 AND SER-657, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336 AND SER-657, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336; THR-654 AND SER-657, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDCAF6_HUMAN
AccessioniPrimary (citable) accession number: Q58WW2
Secondary accession number(s): A2A295
, B4DNB8, Q7L8I0, Q8IXH3, Q8TB19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 26, 2005
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.