Q58P26 (Q58P26_ENTHI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ornithine decarboxylase EMBL AAX35675.1

Submitted name:
Ornithine decarboxylase, putative EMBL EAL49727.1

Gene names

ORF Names:

EHI_100430 EMBL EAL49727.1

Organism

Entamoeba histolytica [Reference proteome] EMBL AAX35675.1

Taxonomic identifier

5759 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Archamoebae › Entamoebidae › Entamoeba

Protein attributes

Sequence length	413 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. RuleBase RU003737

Ontologies

Keywords
Biological process	Polyamine biosynthesis RuleBase RU003739
Technical term	3D-structure PDB 4AIB Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q58P26 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: BEB7F00C87870E45	FASTA	413	46,432
	10 20 30 40 50 60 MKQTSLEVKE FALNLISQFE PENQPLGFWI FDTEGVEKAV ERWKKNMPTV RPCFAVKCNP 70 80 90 100 110 120 EPHLVKLLGE LGCGFDCASL NEIKEVLDLG FNPEDITYSQ TFKPYNQLIE ASHLGINHTI 130 140 150 160 170 180 VDSIDEVQKI AKYAPKMGIM IRIMENDTSA GHVFGEKFGL HDDEVEIVLK EIKDKGLNLD 190 200 210 220 230 240 GVHFHVGSDS HNSEVFTKAL TKARNTVTLA EQFGMKPYLI DIGGGFSQVA PFEEFAATIE 250 260 270 280 290 300 KTIKELEFPE RTRFIAEPGR YMASNAFHLV SSLHGKRVRI QNGKKQIEYT SGDGLHGSFG 310 320 330 340 350 360 CCIWFEKQKS CECITQKVNE NTKMYESIIY GPSCNGSDKV ATQELPEMEP GKDWLLFPNM 370 380 390 400 410 GAYTISMATN FNGFEERNHV IYTLPLKSTK IIQIPKSIEC NSVPSLNGIP HYA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the protist parasite Entamoeba histolytica." Loftus B.J., Anderson I., Davies R., Alsmark U.C., Samuelson J., Amedeo P., Roncaglia P., Berriman M., Hirt R.P., Mann B.J., Nozaki T., Suh B., Pop M., Duchene M., Ackers J., Tannich E., Leippe M., Hofer M. , Bruchhaus I., Willhoeft U., Bhattacharya A., Chillingworth T., Churcher C.M., Hance Z., Harris B., Harris D., Jagels K., Moule S., Mungall K.L., Ormond D., Squares R., Whitehead S., Quail M.A., Rabbinowitsch E., Norbertczak H., Price C., Wang Z., Guillen N., Gilchrist C., Stroup S.E., Bhattacharya S., Lohia A., Foster P.G., Sicheritz-Ponten T., Weber C., Singh U., Mukherjee C., El-Sayed N.M.A., Petri W.A., Clark C.G., Embley T.M., Barrell B.G., Fraser C.M., Hall N. Nature 433:865-868(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 30459 / HM-1:IMSS.
[2]	Prasad K.P., Madhubala R. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 30459 / HM-1:IMSS.
[4]	"Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution." Preeti, Tapas S., Kumar P., Madhubala R., Tomar S. PLoS ONE 8:e53397-e53397(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.87 ANGSTROMS) OF 1-395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY929249 Genomic DNA. Translation: AAX35675.1.
DS571201 Genomic DNA. Translation: EAL49727.1.

RefSeq

XP_655113.1. XM_650021.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4AIB	X-ray	2.87	A/B/C/D	1-395	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

294381.C4M0T2.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

rna_EHI_100430-1; rna_EHI_100430-1; EHI_100430.

GeneID

3409429.

KEGG

ehi:EHI_100430.

Organism-specific databases

EuPathDB

AmoebaDB:EHI_100430.

Phylogenomic databases

KO

K01581.

ProtClustDB

CLSZ2732231.

Family and domain databases

Gene3D

2.40.37.10. 1 hit.

InterPro

IPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
[Graphical view]

Pfam

PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]

PRINTS

PR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.

SUPFAM

SSF50621. Racem_decarbox_C. 1 hit.

PROSITE

PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q58P26_ENTHI

Accession

Primary (citable) accession number: Q58P26
Secondary accession number(s): C4M0T2

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)