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Protein
Submitted name:

Ornithine decarboxylase

Gene

EHI_100430

Organism
Entamoeba histolytica
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ornithine decarboxylase activity Source: CACAO

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Polyamine biosynthesisUniRule annotation

Enzyme and pathway databases

BRENDAi4.1.1.17. 2080.

Names & Taxonomyi

Protein namesi
Submitted name:
Ornithine decarboxylaseImported
Submitted name:
Ornithine decarboxylase, putativeImported
Gene namesi
ORF Names:EHI_100430Imported
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_100430.

Interactioni

Protein-protein interaction databases

STRINGi5759.rna_EHI_100430-1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AIBX-ray2.87A/B/C/D1-395[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family.UniRule annotation

Phylogenomic databases

KOiK01581.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58P26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQTSLEVKE FALNLISQFE PENQPLGFWI FDTEGVEKAV ERWKKNMPTV
60 70 80 90 100
RPCFAVKCNP EPHLVKLLGE LGCGFDCASL NEIKEVLDLG FNPEDITYSQ
110 120 130 140 150
TFKPYNQLIE ASHLGINHTI VDSIDEVQKI AKYAPKMGIM IRIMENDTSA
160 170 180 190 200
GHVFGEKFGL HDDEVEIVLK EIKDKGLNLD GVHFHVGSDS HNSEVFTKAL
210 220 230 240 250
TKARNTVTLA EQFGMKPYLI DIGGGFSQVA PFEEFAATIE KTIKELEFPE
260 270 280 290 300
RTRFIAEPGR YMASNAFHLV SSLHGKRVRI QNGKKQIEYT SGDGLHGSFG
310 320 330 340 350
CCIWFEKQKS CECITQKVNE NTKMYESIIY GPSCNGSDKV ATQELPEMEP
360 370 380 390 400
GKDWLLFPNM GAYTISMATN FNGFEERNHV IYTLPLKSTK IIQIPKSIEC
410
NSVPSLNGIP HYA
Length:413
Mass (Da):46,432
Last modified:April 26, 2005 - v1
Checksum:iBEB7F00C87870E45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY929249 Genomic DNA. Translation: AAX35675.1.
DS571201 Genomic DNA. Translation: EAL49727.1.
RefSeqiXP_655113.1. XM_650021.1.

Genome annotation databases

EnsemblProtistsirna_EHI_100430-1; rna_EHI_100430-1; EHI_100430.
GeneIDi3409429.
KEGGiehi:EHI_100430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY929249 Genomic DNA. Translation: AAX35675.1.
DS571201 Genomic DNA. Translation: EAL49727.1.
RefSeqiXP_655113.1. XM_650021.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AIBX-ray2.87A/B/C/D1-395[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5759.rna_EHI_100430-1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsirna_EHI_100430-1; rna_EHI_100430-1; EHI_100430.
GeneIDi3409429.
KEGGiehi:EHI_100430.

Organism-specific databases

EuPathDBiAmoebaDB:EHI_100430.

Phylogenomic databases

KOiK01581.

Enzyme and pathway databases

BRENDAi4.1.1.17. 2080.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSSImported.
  2. Prasad K.P., Madhubala R.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSSImported.
  4. "Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution."
    Preeti, Tapas S., Kumar P., Madhubala R., Tomar S.
    PLoS ONE 8:e53397-e53397(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.87 ANGSTROMS) OF 1-395.

Entry informationi

Entry nameiQ58P26_ENTHI
AccessioniPrimary (citable) accession number: Q58P26
Secondary accession number(s): C4M0T2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 24, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.