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Q58P26

- Q58P26_ENTHI

UniProt

Q58P26 - Q58P26_ENTHI

Protein
Submitted name:

Ornithine decarboxylase

Gene

EHI_100430

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. catalytic activity Source: InterPro

    GO - Biological processi

    1. polyamine biosynthetic process Source: UniProtKB-KW

    Keywords - Biological processi

    Polyamine biosynthesisUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ornithine decarboxylaseImported
    Submitted name:
    Ornithine decarboxylase, putativeImported
    Gene namesi
    ORF Names:EHI_100430Imported
    OrganismiEntamoeba histolyticaImported
    Taxonomic identifieri5759 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
    ProteomesiUP000001926: Partially assembled WGS sequence

    Organism-specific databases

    EuPathDBiAmoebaDB:EHI_100430.

    Interactioni

    Protein-protein interaction databases

    STRINGi294381.C4M0T2.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AIBX-ray2.87A/B/C/D1-395[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family.UniRule annotation

    Phylogenomic databases

    KOiK01581.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR002433. Orn_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PRINTSiPR01179. ODADCRBXLASE.
    PR01182. ORNDCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q58P26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQTSLEVKE FALNLISQFE PENQPLGFWI FDTEGVEKAV ERWKKNMPTV    50
    RPCFAVKCNP EPHLVKLLGE LGCGFDCASL NEIKEVLDLG FNPEDITYSQ 100
    TFKPYNQLIE ASHLGINHTI VDSIDEVQKI AKYAPKMGIM IRIMENDTSA 150
    GHVFGEKFGL HDDEVEIVLK EIKDKGLNLD GVHFHVGSDS HNSEVFTKAL 200
    TKARNTVTLA EQFGMKPYLI DIGGGFSQVA PFEEFAATIE KTIKELEFPE 250
    RTRFIAEPGR YMASNAFHLV SSLHGKRVRI QNGKKQIEYT SGDGLHGSFG 300
    CCIWFEKQKS CECITQKVNE NTKMYESIIY GPSCNGSDKV ATQELPEMEP 350
    GKDWLLFPNM GAYTISMATN FNGFEERNHV IYTLPLKSTK IIQIPKSIEC 400
    NSVPSLNGIP HYA 413
    Length:413
    Mass (Da):46,432
    Last modified:April 26, 2005 - v1
    Checksum:iBEB7F00C87870E45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY929249 Genomic DNA. Translation: AAX35675.1.
    DS571201 Genomic DNA. Translation: EAL49727.1.
    RefSeqiXP_655113.1. XM_650021.1.

    Genome annotation databases

    EnsemblProtistsirna_EHI_100430-1; rna_EHI_100430-1; EHI_100430.
    GeneIDi3409429.
    KEGGiehi:EHI_100430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY929249 Genomic DNA. Translation: AAX35675.1 .
    DS571201 Genomic DNA. Translation: EAL49727.1 .
    RefSeqi XP_655113.1. XM_650021.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AIB X-ray 2.87 A/B/C/D 1-395 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 294381.C4M0T2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi rna_EHI_100430-1 ; rna_EHI_100430-1 ; EHI_100430 .
    GeneIDi 3409429.
    KEGGi ehi:EHI_100430.

    Organism-specific databases

    EuPathDBi AmoebaDB:EHI_100430.

    Phylogenomic databases

    KOi K01581.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR002433. Orn_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PRINTSi PR01179. ODADCRBXLASE.
    PR01182. ORNDCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 30459 / HM-1:IMSSImported.
    2. Prasad K.P., Madhubala R.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 30459 / HM-1:IMSSImported.
    4. "Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution."
      Preeti, Tapas S., Kumar P., Madhubala R., Tomar S.
      PLoS ONE 8:e53397-e53397(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.87 ANGSTROMS) OF 1-395.

    Entry informationi

    Entry nameiQ58P26_ENTHI
    AccessioniPrimary (citable) accession number: Q58P26
    Secondary accession number(s): C4M0T2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3