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Q58P26

- Q58P26_ENTHI

UniProt

Q58P26 - Q58P26_ENTHI

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Protein
Submitted name:

Ornithine decarboxylase

Gene

EHI_100430

Organism
Entamoeba histolytica
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. catalytic activity Source: InterPro

GO - Biological processi

  1. polyamine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Polyamine biosynthesisUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Ornithine decarboxylaseImported
Submitted name:
Ornithine decarboxylase, putativeImported
Gene namesi
ORF Names:EHI_100430Imported
OrganismiEntamoeba histolyticaImported
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000001926: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EHI_100430.

Interactioni

Protein-protein interaction databases

STRINGi294381.C4M0T2.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AIBX-ray2.87A/B/C/D1-395[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family.UniRule annotation

Phylogenomic databases

KOiK01581.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58P26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKQTSLEVKE FALNLISQFE PENQPLGFWI FDTEGVEKAV ERWKKNMPTV
60 70 80 90 100
RPCFAVKCNP EPHLVKLLGE LGCGFDCASL NEIKEVLDLG FNPEDITYSQ
110 120 130 140 150
TFKPYNQLIE ASHLGINHTI VDSIDEVQKI AKYAPKMGIM IRIMENDTSA
160 170 180 190 200
GHVFGEKFGL HDDEVEIVLK EIKDKGLNLD GVHFHVGSDS HNSEVFTKAL
210 220 230 240 250
TKARNTVTLA EQFGMKPYLI DIGGGFSQVA PFEEFAATIE KTIKELEFPE
260 270 280 290 300
RTRFIAEPGR YMASNAFHLV SSLHGKRVRI QNGKKQIEYT SGDGLHGSFG
310 320 330 340 350
CCIWFEKQKS CECITQKVNE NTKMYESIIY GPSCNGSDKV ATQELPEMEP
360 370 380 390 400
GKDWLLFPNM GAYTISMATN FNGFEERNHV IYTLPLKSTK IIQIPKSIEC
410
NSVPSLNGIP HYA
Length:413
Mass (Da):46,432
Last modified:April 26, 2005 - v1
Checksum:iBEB7F00C87870E45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY929249 Genomic DNA. Translation: AAX35675.1.
DS571201 Genomic DNA. Translation: EAL49727.1.
RefSeqiXP_655113.1. XM_650021.1.

Genome annotation databases

EnsemblProtistsirna_EHI_100430-1; rna_EHI_100430-1; EHI_100430.
GeneIDi3409429.
KEGGiehi:EHI_100430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY929249 Genomic DNA. Translation: AAX35675.1 .
DS571201 Genomic DNA. Translation: EAL49727.1 .
RefSeqi XP_655113.1. XM_650021.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AIB X-ray 2.87 A/B/C/D 1-395 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 294381.C4M0T2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi rna_EHI_100430-1 ; rna_EHI_100430-1 ; EHI_100430 .
GeneIDi 3409429.
KEGGi ehi:EHI_100430.

Organism-specific databases

EuPathDBi AmoebaDB:EHI_100430.

Phylogenomic databases

KOi K01581.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PRINTSi PR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 30459 / HM-1:IMSSImported.
  2. Prasad K.P., Madhubala R.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 30459 / HM-1:IMSSImported.
  4. "Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution."
    Preeti, Tapas S., Kumar P., Madhubala R., Tomar S.
    PLoS ONE 8:e53397-e53397(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.87 ANGSTROMS) OF 1-395.

Entry informationi

Entry nameiQ58P26_ENTHI
AccessioniPrimary (citable) accession number: Q58P26
Secondary accession number(s): C4M0T2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3