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Protein

Dehydrogenase/reductase SDR family member 9

Gene

Dhrs9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83NADBy similarity1
Binding sitei164SubstrateBy similarity1
Active sitei176Proton acceptorBy similarity1
Binding sitei180NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 58NADBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

ReactomeiR-MMU-5365859. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 9 (EC:1.1.-.-)
Alternative name(s):
3-alpha hydroxysteroid dehydrogenase
Short name:
3-alpha-HSD
Short-chain dehydrogenase/reductase retSDR8
Gene namesi
Name:Dhrs9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442798. Dhrs9.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004261821 – 319Dehydrogenase/reductase SDR family member 9Add BLAST299

Proteomic databases

MaxQBiQ58NB6.
PaxDbiQ58NB6.
PRIDEiQ58NB6.

PTM databases

PhosphoSitePlusiQ58NB6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027068.
CleanExiMM_DHRS9.
ExpressionAtlasiQ58NB6. baseline and differential.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ58NB6. 1 interactor.
MINTiMINT-4110286.
STRINGi10090.ENSMUSP00000069631.

Structurei

3D structure databases

ProteinModelPortaliQ58NB6.
SMRiQ58NB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00890000139345.
HOVERGENiHBG005482.
InParanoidiQ58NB6.
KOiK11149.
OMAiLFPKTHY.
OrthoDBiEOG091G0LMI.
PhylomeDBiQ58NB6.
TreeFamiTF325617.

Family and domain databases

InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58NB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFWLLALLF LCAFLWNYKG QLKIADIADK YVFITGCDTG FGNLAARTFD
60 70 80 90 100
KKGFRVIAAC LTESGSAALK AKTSERLHTV LLDVTDPENV KKTAQWVKSH
110 120 130 140 150
VGEKGLWGLI NNAGVLGVLA PTDWLTVDDY REPIEVNLFG LINVTLNMLP
160 170 180 190 200
LVKKARGRVI NVSSIGGRLA FGGGGYTPSK YAVEGFNDSL RRDMKAFGVH
210 220 230 240 250
VSCIEPGLFK TELADPIKTT EKKLAIWKHL SPDIKQQYGE GYIEKSLHRL
260 270 280 290 300
KSNTSSVNLD LSLVVGCMDH ALTSLFPKTR YIAGKDAKTF WIPLSHMPAV
310
LQDFLLLKQK VELANPKAV
Length:319
Mass (Da):35,242
Last modified:October 25, 2005 - v2
Checksum:iA8111F84ED57BB19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 5FWL → LWV in AAX33670 (Ref. 2) Curated3
Sequence conflicti292I → L in AAX33670 (Ref. 2) Curated1
Sequence conflicti317K → Q in AAX33670 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361479 mRNA. Translation: AAN75755.1.
AK050180 mRNA. Translation: BAC34110.1.
AK080914 mRNA. Translation: BAC38075.1.
AY936479 mRNA. Translation: AAX33670.1.
CCDSiCCDS16091.1.
RefSeqiNP_780721.1. NM_175512.2.
UniGeneiMm.211655.

Genome annotation databases

EnsembliENSMUST00000063690; ENSMUSP00000069631; ENSMUSG00000027068.
GeneIDi241452.
KEGGimmu:241452.
UCSCiuc008jyb.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiDHRS9_MOUSE
AccessioniPrimary (citable) accession number: Q58NB6
Secondary accession number(s): Q8BGC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: August 30, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families