Q58NA1 (Q58NA1_TOXGO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Inflammatory profilin EMBL AAX47289.1

Submitted name:
Profilin EMBL AAX33672.1
Submitted name:
Profilin family protein EMBL EEB03031.1

Gene names

Name:	PRF EMBL AAX33672.1
ORF Names:	TGGT1_074080 EMBL EEE20975.1, TgIa.1570 EMBL CAJ20409.1, TGME49_093690 EMBL EEB03031.1, TGVEG_014090 EMBL EEE28875.1

Organism

Toxoplasma gondii EMBL AAX33672.1

Taxonomic identifier

5811 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Apicomplexa › Coccidia › Eucoccidiorida › Eimeriorina › Sarcocystidae › Toxoplasma

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 3NEC Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular component	actin cytoskeleton Inferred from electronic annotation. Source: InterPro
Molecular function	actin binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q58NA1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: F2927D287C12E514	FASTA	163	17,555
	10 20 30 40 50 60 MSDWDPVVKE WLVDTGYCCA GGIANAEDGV VFAAAADDDD GWSKLYKDDH EEDTIGEDGN 70 80 90 100 110 120 ACGKVSINEA STIKAAVDDG SAPNGVWIGG QKYKVVRPEK GFEYNDCTFD ITMCARSKGG 130 140 150 160 AHLIKTPNGS IVIALYDEEK EQDKGNSRTS ALAFAEYLHQ SGY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii." Sahoo N., Beatty W., Heuser J., Sept D., Sibley L.D. Mol. Biol. Cell 17:895-906(2006) [PubMed: 16319175] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: RH EMBL AAX33672.1.
[2]	"Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11." Kucera K., Koblansky A.A., Saunders L.P., Frederick K.B., De La Cruz E.M., Ghosh S., Modis Y. J. Mol. Biol. 403:616-629(2010) [PubMed: 20851125] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
[3]	"Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii." Khan A., Bohme U., Kelly K.A., Adlem E., Brooks K., Simmonds M., Mungall K., Quail M.A., Arrowsmith C., Chillingworth T., Churcher C., Harris D., Collins M., Fosker N., Fraser A., Hance Z., Jagels K., Moule S. , Murphy L., O'Neil S., Rajandream M.-A., Saunders D., Seeger K., Whitehead S., Mayr T., Xuan X., Watanabe J., Suzuki Y., Wakaguri H., Sugano S., Sugimoto C., Paulsen I., Mackey A.J., Roos D.S., Hall N., Berriman M., Barrell B., Sibley L.D., Ajioka J.W. Genome Res. 16:1119-1125(2006) [PubMed: 16902086] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RH EMBL CAJ20409.1.
[4]	"Annotation of Toxoplasma gondii ME49." Lorenzi H., Caler E., Galinsky K., Schobel S., Brunk B.P., Roos D.S., Paulsen I. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 50611 / Me49 and ME49 EMBL EEB03031.1.
[5]	Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: GT1 EMBL EEE20975.1 and VEG EMBL EEE28875.1.
[6]	"A profilin-like protein from Toxoplasma gondii potently triggers dendritic cell IL-12 production through TLR11." Yarovinsky F., Zhang D., Andersen J.F., Bannenberg G.L., Serhan C.N., Hayden M.S., Hieny S., Sutterwala F., Flavell R.A., Ghosh S., Sher A. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[7]	"Annotation of Toxoplasma gondii GT1." Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GT1.
[8]	"Annotation of Toxoplasma gondii VEG." Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 50861 / VEG.
[9]	Skillman K.M., Sibley D. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: RH EMBL AAX33672.1.
[10]	Boehme U. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: RH EMBL CAJ20409.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY937257 mRNA. Translation: AAX33672.1.
AY897579 mRNA. Translation: AAX47289.1.
AM055942 Genomic DNA. Translation: CAJ20409.1.
DS984743 Genomic DNA. Translation: EEB03031.1.
EQ967489 Genomic DNA. Translation: EEE20975.1.
EQ970694 Genomic DNA. Translation: EEE28875.1.

RefSeq

XP_002370171.1. XM_002370130.1.

UniGene

Tgo.9805.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3NEC	X-ray	1.70	A/B/C/D	1-163	[»]

ProteinModelPortal

Q58NA1.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

7900190.

KEGG

tgo:TGME49_093690.

Organism-specific databases

EuPathDB

EupathDB:TGME49_093690.

Phylogenomic databases

ProtClustDB

CLSZ2431607.

Family and domain databases

InterPro

IPR002097. Profilin.
IPR016814. Profilin_apicomplexa.
[Graphical view]

KO

K14141.

Pfam

PF00235. Profilin. 1 hit.
[Graphical view]

PIRSF

PIRSF022993. Profilin_apicomplexa. 1 hit.

SUPFAM

SSF55770. Profilin. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q58NA1_TOXGO

Accession

Primary (citable) accession number: Q58NA1
Secondary accession number(s): B6KQP8 , B9PY60, B9QLE3, Q1JT65

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	November 16, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)