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Protein
Submitted name:

Na+/K+ ATPase gamma subunit transcript variant a

Gene

FXYD2

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled transmembrane transport Source: BHF-UCL
  • establishment or maintenance of transmembrane electrochemical gradient Source: BHF-UCL
  • potassium ion import across plasma membrane Source: BHF-UCL
  • sodium ion export from cell Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Na+/K+ ATPase gamma subunit transcript variant aImported
Gene namesi
Name:FXYD2Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4719HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • sodium:potassium-exchanging ATPase complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ58K79.

Expressioni

Gene expression databases

GenevisibleiQ58K79. SS.

Interactioni

Protein-protein interaction databases

DIPiDIP-60367N.
STRINGi9823.ENSSSCP00000016007.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B8EX-ray3.50G/H23-51[»]
3KDPX-ray3.50G/H23-49[»]
3N23X-ray4.60E/G17-47[»]
3WGUX-ray2.80E/G1-65[»]
3WGVX-ray2.80E/G1-65[»]
4HQJX-ray4.30E/G1-65[»]
4HYTX-ray3.40E/G1-65[»]
4RESX-ray3.41E/G1-65[»]
4RETX-ray4.00E/G1-65[»]
ProteinModelPortaliQ58K79.
SMRiQ58K79. Positions 23-51.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58K79.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410J35I. Eukaryota.
ENOG410Z10F. LUCA.
HOGENOMiHOG000234468.
HOVERGENiHBG100880.
KOiK01538.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58K79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLSTDDGG SPKGDVDPFY YDYETVRNGG LIFAALAFIV GLIIILSKRL
60
RCGGKKHRPI NEDEL
Length:65
Mass (Da):7,085
Last modified:April 26, 2005 - v1
Checksum:i7B7EA8AB227D5F6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY941203 mRNA. Translation: AAX37665.1.
RefSeqiNP_001014427.1. NM_001014427.1.
UniGeneiSsc.23103.

Genome annotation databases

GeneIDi541593.
KEGGissc:541593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY941203 mRNA. Translation: AAX37665.1.
RefSeqiNP_001014427.1. NM_001014427.1.
UniGeneiSsc.23103.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B8EX-ray3.50G/H23-51[»]
3KDPX-ray3.50G/H23-49[»]
3N23X-ray4.60E/G17-47[»]
3WGUX-ray2.80E/G1-65[»]
3WGVX-ray2.80E/G1-65[»]
4HQJX-ray4.30E/G1-65[»]
4HYTX-ray3.40E/G1-65[»]
4RESX-ray3.41E/G1-65[»]
4RETX-ray4.00E/G1-65[»]
ProteinModelPortaliQ58K79.
SMRiQ58K79. Positions 23-51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60367N.
STRINGi9823.ENSSSCP00000016007.

Proteomic databases

PaxDbiQ58K79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi541593.
KEGGissc:541593.

Organism-specific databases

CTDi486.

Phylogenomic databases

eggNOGiENOG410J35I. Eukaryota.
ENOG410Z10F. LUCA.
HOGENOMiHOG000234468.
HOVERGENiHBG100880.
KOiK01538.

Miscellaneous databases

EvolutionaryTraceiQ58K79.

Gene expression databases

GenevisibleiQ58K79. SS.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Covalent cross-links between the gamma subunit (FXYD2) and alpha and beta subunits of Na,K-ATPase: modeling the alpha-gamma interaction."
    Fuzesi M., Gottschalk K.E., Lindzen M., Shainskaya A., Kuster B., Garty H., Karlish S.J.
    J. Biol. Chem. 280:18291-18301(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) OF 23-49.
  3. "Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase."
    Yatime L., Laursen M., Morth J.P., Esmann M., Nissen P., Fedosova N.U.
    J. Struct. Biol. 174:296-306(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.60 ANGSTROMS) OF 17-47.
  4. "Crystal structure of a Na1-bound Na1,K1-ATPase preceding the E1P state."
    Kanai R., Ogawa H., Vilsen B., Cornelius F., Toyoshima C.
    Nature 502:201-206(2013)
    Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS).
  5. "Crystal structure of the high-affinity Na+K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site."
    Laursen M., Yatime L., Nissen P., Fedosova N.U.
    Proc. Natl. Acad. Sci. U.S.A. 110:10958-10963(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS).
  6. "Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state."
    Nyblom M., Poulsen H., Gourdon P., Reinhard L., Andersson M., Lindahl E., Fedosova N., Nissen P.
    Science 342:123-127(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.30 ANGSTROMS).
  7. "Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex."
    Laursen M., Gregersen J.L., Yatime L., Nissen P., Fedosova N.U.
    Proc. Natl. Acad. Sci. U.S.A. 112:1755-1760(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.41 ANGSTROMS).

Entry informationi

Entry nameiQ58K79_PIG
AccessioniPrimary (citable) accession number: Q58K79
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: January 20, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.