Q58HK4 (3DHQ_NEUAF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catabolic 3-dehydroquinase
Short name=cDHQase
EC=4.2.1.10

Alternative name(s):
3-dehydroquinate dehydratase

Gene names

Name:

qa-2

Organism

Neurospora africana

Taxonomic identifier

5143 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway By similarity.
Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O.
Pathway	Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.
Subunit structure	Homododecamer By similarity. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another By similarity.
Sequence similarities	Belongs to the type-II 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Quinate metabolism
Molecular function	Lyase
Gene Ontology (GO)
Biological process	quinate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Catabolic 3-dehydroquinase		PRO_0000260167
Regions
	Region	124 – 125	2	Substrate binding By similarity
Sites
	Active site	26	1	Proton acceptor By similarity
	Active site	123	1	Proton donor By similarity
	Binding site	97	1	Substrate By similarity
	Binding site	103	1	Substrate By similarity
	Binding site	110	1	Substrate By similarity
	Binding site	134	1	Substrate By similarity
	Site	21	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58HK4 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: BA8A8E88AD19E826	FASTA	168	17,961
	10 20 30 40 50 60 MASRHHILLI NGPNLNLLGT REPQIYGSTT LHDIEQAAQT QASSLDLRLT TFQSNHEGAI 70 80 90 100 110 120 IDRIHQAAGF FPSPSGPATI AEADPGAGEK VSAIIINPGA YTHTSVGIRD ALLGTGIPFV 130 140 150 160 EVHVSNVHAR EAFRHHSYLS DKAVAVICGL GPYGYSAALE FVGRHMKF

References

[1]	"Comparative sequencing of the qa-2 gene of Neurospora africana." Arnett D.R., Shevchuk J.A., Asch D.K. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY948979 Genomic DNA. Translation: AAX51222.1.
3D structure databases
HSSP	HSSP built from PDB template 1UQR based on UniProtKB P43877.
ProteinModelPortal	Q58HK4.
SMR	Q58HK4. Positions 6-167.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001874. DHquinase_II. IPR018509. DHquinase_II_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.9100. DHquinase_II. 1 hit.
PANTHER	PTHR21272. DHquinase_II. 1 hit.
Pfam	PF01220. DHquinase_II. 1 hit. [Graphical view]
PIRSF	PIRSF001399. DHquinase_II. 1 hit.
ProDom	PD004527. DHquinase_II. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF52304. DHquinase_II. 1 hit.
PROSITE	PS01029. DEHYDROQUINASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

3DHQ_NEUAF

Accession

Primary (citable) accession number: Q58HK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	April 26, 2005
Last modified:	May 31, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program