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Protein

Putative synaptotagmin-14-like protein

Gene

SYT14P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein uncertaini

Functioni

Plays a role in melanocyte differentiation; enhances dendrite outgrowth, melanin content and tyrosinase activity through the modulation of ERK and/or CREB pathways (PubMed:23999003).2 Publications

GO - Molecular functioni

GO - Biological processi

  • positive regulation of CREB transcription factor activity Source: UniProtKB
  • positive regulation of dendrite extension Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • vesicle fusion Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative synaptotagmin-14-like proteinCurated
Alternative name(s):
Synaptotagmin XIV protein pseudogene 1Imported
Synaptotagmin XIV-derived protein1 Publication
Synaptotagmin XIV-like protein1 Publication
Gene namesi
Name:SYT14P1Imported
Synonyms:SYT14L1 Publication, SYT14LP1, SYTDEP1 PublicationImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:33429. SYT14P1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166979750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Putative synaptotagmin-14-like proteinPRO_0000318116Add
BLAST

Proteomic databases

PRIDEiQ58G82.

Expressioni

Tissue specificityi

Expressed in mature peripheral blood neutrophils (at protein level) (PubMed:16376304). Expressed in heart, pancreas, liver and skeletal muscle (PubMed:11543631). Expressed in umbilical vein endothelial cells and melanocytes (PubMed:23999003).3 Publications

Developmental stagei

Up-regulated during neutrophil differentiation (PubMed:16376304).1 Publication

Inductioni

Up-regulated during neutrophil differentiation (PubMed:16376304).1 Publication

Gene expression databases

CleanExiHS_SYT14L.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ58G82.
SMRiQ58G82. Positions 17-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 154104C2PROSITE-ProRule annotationAdd
BLAST

Domaini

The C2 domain is necessary and sufficient to promote melanocyte dendrite outgrowth (PubMed:23999003).1 Publication

Sequence similaritiesi

Belongs to the synaptotagmin family.Sequence analysis
Contains 1 C2 domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG095478.
InParanoidiQ58G82.
PhylomeDBiQ58G82.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR028696. SYT14.
[Graphical view]
PANTHERiPTHR10024:SF209. PTHR10024:SF209. 1 hit.
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58G82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEGFQILVQ NTVQGTIHKI KCVCDSQMSV SEMSCSESTS ACQSLEDGSV
60 70 80 90 100
PEILISLLYN ATNGRLSAEV IKGSHLKNWA ANRPPNTYVK LTLRKSTDQE
110 120 130 140 150
MSKCKISIRR GRPNPVYKET FVFKVTLFQL SHVTLMLSVY NKSSMRRKMI
160 170 180
GWIYLGLNSS GEELNHWTEM KESKGRQVRR WQALLESR
Length:188
Mass (Da):21,436
Last modified:February 5, 2008 - v2
Checksum:iFF3481AFDB726C85
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971T → M.1 Publication
Corresponds to variant rs3819257 [ dbSNP | Ensembl ].
VAR_038691

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY954513 mRNA. Translation: AAX40990.1.
AC096727 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05567.1.
BC132697 mRNA. No translation available.
AJ303368 mRNA. Translation: CAC33890.1.
UniGeneiHs.130270.
Hs.712109.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY954513 mRNA. Translation: AAX40990.1.
AC096727 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05567.1.
BC132697 mRNA. No translation available.
AJ303368 mRNA. Translation: CAC33890.1.
UniGeneiHs.130270.
Hs.712109.

3D structure databases

ProteinModelPortaliQ58G82.
SMRiQ58G82. Positions 17-186.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi166979750.

Proteomic databases

PRIDEiQ58G82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

HGNCiHGNC:33429. SYT14P1.
MIMi610892. gene.
neXtProtiNX_Q58G82.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG095478.
InParanoidiQ58G82.
PhylomeDBiQ58G82.

Miscellaneous databases

PROiQ58G82.
SOURCEiSearch...

Gene expression databases

CleanExiHS_SYT14L.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR028696. SYT14.
[Graphical view]
PANTHERiPTHR10024:SF209. PTHR10024:SF209. 1 hit.
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSY14L_HUMAN
AccessioniPrimary (citable) accession number: Q58G82
Secondary accession number(s): A2RTZ8, Q9BQR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 8, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. Encoded by an expressed retrotransposed copy of the SYT14 locus into an intron of TMPRSS11F.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.