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Protein

Putative synaptotagmin-14-like protein

Gene

SYT14P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Plays a role in melanocyte differentiation; enhances dendrite outgrowth, melanin content and tyrosinase activity through the modulation of ERK and/or CREB pathways (PubMed:23999003).2 Publications

Caution

Could be the product of a pseudogene. Encoded by an expressed retrotransposed copy of the SYT14 locus into an intron of TMPRSS11F.Curated

GO - Molecular functioni

GO - Biological processi

  • positive regulation of CREB transcription factor activity Source: UniProtKB
  • positive regulation of dendrite extension Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • vesicle fusion Source: GO_Central

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative synaptotagmin-14-like proteinCurated
Alternative name(s):
Synaptotagmin XIV protein pseudogene 1Imported
Synaptotagmin XIV-derived protein1 Publication
Synaptotagmin XIV-like protein1 Publication
Gene namesi
Name:SYT14P1Imported
Synonyms:SYT14L1 Publication, SYT14LP1, SYTDEP1 PublicationImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:33429 SYT14P1
MIMi610892 gene
neXtProtiNX_Q58G82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166979750

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181161 – 188Putative synaptotagmin-14-like proteinAdd BLAST188

Proteomic databases

MaxQBiQ58G82
PRIDEiQ58G82

Expressioni

Tissue specificityi

Expressed in mature peripheral blood neutrophils (at protein level) (PubMed:16376304). Expressed in heart, pancreas, liver and skeletal muscle (PubMed:11543631). Expressed in umbilical vein endothelial cells and melanocytes (PubMed:23999003).3 Publications

Developmental stagei

Up-regulated during neutrophil differentiation (PubMed:16376304).1 Publication

Inductioni

Up-regulated during neutrophil differentiation (PubMed:16376304).1 Publication

Gene expression databases

CleanExiHS_SYT14L

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ58G82
SMRiQ58G82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 154C2PROSITE-ProRule annotationAdd BLAST104

Domaini

The C2 domain is necessary and sufficient to promote melanocyte dendrite outgrowth (PubMed:23999003).1 Publication

Sequence similaritiesi

Belongs to the synaptotagmin family.Sequence analysis

Phylogenomic databases

HOVERGENiHBG095478
InParanoidiQ58G82
PhylomeDBiQ58G82

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028696 SYT14
PANTHERiPTHR10024:SF209 PTHR10024:SF209, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequencei

Sequence statusi: Complete.

Q58G82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEGFQILVQ NTVQGTIHKI KCVCDSQMSV SEMSCSESTS ACQSLEDGSV
60 70 80 90 100
PEILISLLYN ATNGRLSAEV IKGSHLKNWA ANRPPNTYVK LTLRKSTDQE
110 120 130 140 150
MSKCKISIRR GRPNPVYKET FVFKVTLFQL SHVTLMLSVY NKSSMRRKMI
160 170 180
GWIYLGLNSS GEELNHWTEM KESKGRQVRR WQALLESR
Length:188
Mass (Da):21,436
Last modified:February 5, 2008 - v2
Checksum:iFF3481AFDB726C85
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03869197T → M1 PublicationCorresponds to variant dbSNP:rs3819257Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY954513 mRNA Translation: AAX40990.1
AC096727 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05567.1
BC132697 mRNA No translation available.
AJ303368 mRNA Translation: CAC33890.1
UniGeneiHs.130270
Hs.712109

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSY14L_HUMAN
AccessioniPrimary (citable) accession number: Q58G82
Secondary accession number(s): A2RTZ8, Q9BQR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health