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Protein

Kynurenine--oxoglutarate transaminase 3

Gene

Kyat3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).By similarity

Catalytic activityi

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
An L-cysteine-S-conjugate + H2O = RSH + NH3 + pyruvate.
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53SubstrateBy similarity1
Binding sitei71Substrate; via amide nitrogenBy similarity1
Binding sitei218SubstrateBy similarity1
Binding sitei429SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Lyase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDAi2.6.1.7 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine--oxoglutarate transaminase 3 (EC:2.6.1.7)
Alternative name(s):
Cysteine-S-conjugate beta-lyase 2 (EC:4.4.1.13)
Kynurenine aminotransferase 3Imported
Kynurenine aminotransferase III
Short name:
KATIII
Kynurenine--glyoxylate transaminase (EC:2.6.1.63)
Kynurenine--oxoglutarate transaminase III
Gene namesi
Name:Kyat3Imported
Synonyms:Ccbl2, Kat3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359262 Kyat3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002877061 – 454Kynurenine--oxoglutarate transaminase 3Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116N6-acetyllysine; alternateBy similarity1
Modified residuei116N6-succinyllysine; alternateBy similarity1
Modified residuei280N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ58FK9

PTM databases

iPTMnetiQ58FK9
PhosphoSitePlusiQ58FK9

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ58FK9
SMRiQ58FK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008391
InParanoidiQ58FK9
KOiK00816
PhylomeDBiQ58FK9

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR034612 KAT_III
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43807:SF6 PTHR43807:SF6, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q58FK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAQRRLFS LGCRAKPIKT IYSSKVLGLS TSAKMALRFK NAKRIEGLDQ
60 70 80 90 100
NVWVEFTKLA ADPSVVNLGQ GFPDITLPSY VQEELSKAAF IDNLNQYTRG
110 120 130 140 150
FGHPSLVKAL SCLYGKIYQK QIDPNEEILV TVGGYGSLFN AIQGLVDPGD
160 170 180 190 200
EVIIMVPFYD CYEPMVKMAG AVPVFIPLRS KRTDGMKWTS SDWTFNPQEL
210 220 230 240 250
ESKFSSKTKA IILNTPHNPI GKVYTREELQ VIADLCIKHD TLCISDEVYE
260 270 280 290 300
WLVYTGHKHI KVASLPGMWD RTLTIGSAGK TFSVTGWKLG WSIGPGHLIK
310 320 330 340 350
HLRTVQQTSV YTCATPLQAA LAEAFWIDIK RMDDPECYFN SLPKELEVKR
360 370 380 390 400
DRMACLLNSV GLKPIIPDGG YFIIADVSSL GVDLSDVKSD EPYDYKFVKW
410 420 430 440 450
MTKNKKLSAI PVSAFCDSES KPHFEKLVRF CFIKKDSTLD AAEEIFRTWN

SRKS
Length:454
Mass (Da):51,044
Last modified:April 26, 2005 - v1
Checksum:i77F70B4DEC32D9AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY955395 mRNA Translation: AAX55607.1
RefSeqiNP_001015037.1, NM_001015037.1
UniGeneiRn.28263

Genome annotation databases

GeneIDi541589
KEGGirno:541589

Similar proteinsi

Entry informationi

Entry nameiKAT3_RAT
AccessioniPrimary (citable) accession number: Q58FK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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