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Protein

Kynurenine--oxoglutarate transaminase 3

Gene

Kyat3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).By similarity

Catalytic activityi

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
An L-cysteine-S-conjugate + H2O = RSH + NH3 + pyruvate.
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531SubstrateBy similarity
Binding sitei71 – 711Substrate; via amide nitrogenBy similarity
Binding sitei218 – 2181SubstrateBy similarity
Binding sitei429 – 4291SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Lyase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi2.6.1.7. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine--oxoglutarate transaminase 3 (EC:2.6.1.7)
Alternative name(s):
Cysteine-S-conjugate beta-lyase 2 (EC:4.4.1.13)
Kynurenine aminotransferase 3Imported
Kynurenine aminotransferase III
Short name:
KATIII
Kynurenine--glyoxylate transaminase (EC:2.6.1.63)
Kynurenine--oxoglutarate transaminase III
Gene namesi
Name:Kyat3Imported
Synonyms:Ccbl2, Kat3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359262. Kyat3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Kynurenine--oxoglutarate transaminase 3PRO_0000287706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 1161N6-acetyllysine; alternateBy similarity
Modified residuei116 – 1161N6-succinyllysine; alternateBy similarity
Modified residuei280 – 2801N6-(pyridoxal phosphate)lysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ58FK9.

PTM databases

iPTMnetiQ58FK9.
PhosphoSiteiQ58FK9.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ58FK9.
SMRiQ58FK9. Positions 41-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008391.
InParanoidiQ58FK9.
KOiK00816.
PhylomeDBiQ58FK9.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58FK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAQRRLFS LGCRAKPIKT IYSSKVLGLS TSAKMALRFK NAKRIEGLDQ
60 70 80 90 100
NVWVEFTKLA ADPSVVNLGQ GFPDITLPSY VQEELSKAAF IDNLNQYTRG
110 120 130 140 150
FGHPSLVKAL SCLYGKIYQK QIDPNEEILV TVGGYGSLFN AIQGLVDPGD
160 170 180 190 200
EVIIMVPFYD CYEPMVKMAG AVPVFIPLRS KRTDGMKWTS SDWTFNPQEL
210 220 230 240 250
ESKFSSKTKA IILNTPHNPI GKVYTREELQ VIADLCIKHD TLCISDEVYE
260 270 280 290 300
WLVYTGHKHI KVASLPGMWD RTLTIGSAGK TFSVTGWKLG WSIGPGHLIK
310 320 330 340 350
HLRTVQQTSV YTCATPLQAA LAEAFWIDIK RMDDPECYFN SLPKELEVKR
360 370 380 390 400
DRMACLLNSV GLKPIIPDGG YFIIADVSSL GVDLSDVKSD EPYDYKFVKW
410 420 430 440 450
MTKNKKLSAI PVSAFCDSES KPHFEKLVRF CFIKKDSTLD AAEEIFRTWN

SRKS
Length:454
Mass (Da):51,044
Last modified:April 26, 2005 - v1
Checksum:i77F70B4DEC32D9AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY955395 mRNA. Translation: AAX55607.1.
RefSeqiNP_001015037.1. NM_001015037.1.
UniGeneiRn.28263.

Genome annotation databases

GeneIDi541589.
KEGGirno:541589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY955395 mRNA. Translation: AAX55607.1.
RefSeqiNP_001015037.1. NM_001015037.1.
UniGeneiRn.28263.

3D structure databases

ProteinModelPortaliQ58FK9.
SMRiQ58FK9. Positions 41-449.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ58FK9.
PhosphoSiteiQ58FK9.

Proteomic databases

PRIDEiQ58FK9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi541589.
KEGGirno:541589.

Organism-specific databases

CTDi56267.
RGDi1359262. Kyat3.

Phylogenomic databases

HOVERGENiHBG008391.
InParanoidiQ58FK9.
KOiK00816.
PhylomeDBiQ58FK9.

Enzyme and pathway databases

BRENDAi2.6.1.7. 5301.

Miscellaneous databases

PROiQ58FK9.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKAT3_RAT
AccessioniPrimary (citable) accession number: Q58FK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.