Reviewed, UniProtKB/Swiss-Prot Q58FK9 (KAT3_RAT)

Names and origin

Protein names

Recommended name:
    Kynurenine--oxoglutarate transaminase 3
    EC=2.6.1.7
Alternative name(s):
    Kynurenine--oxoglutarate transaminase III
    Kynurenine aminotransferase III
      Short name=KATIII
    Cysteine-S-conjugate beta-lyase 2
    EC=4.4.1.13

Gene names

Name:	Ccbl2
Synonyms:	Kat3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond By similarity.
Catalytic activity	L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. RS-CH(2)-CH(NH3+)COO- = RSH + NH3 + pyruvate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Lyase Transferase
PTM	Acetylation
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: InterPro cysteine-S-conjugate beta-lyase activity Inferred from electronic annotation. Source: EC kynurenine-oxoglutarate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 454	454	Kynurenine--oxoglutarate transaminase 3		PRO_0000287706
Amino acid modifications
	Modified residue	108	1	N6-acetyllysine By similarity
	Modified residue	116	1	N6-acetyllysine By similarity
	Modified residue	280	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58FK9-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 77F70B4DEC32D9AC	FASTA	454	51,044
	10 20 30 40 50 60 MLLAQRRLFS LGCRAKPIKT IYSSKVLGLS TSAKMALRFK NAKRIEGLDQ NVWVEFTKLA 70 80 90 100 110 120 ADPSVVNLGQ GFPDITLPSY VQEELSKAAF IDNLNQYTRG FGHPSLVKAL SCLYGKIYQK 130 140 150 160 170 180 QIDPNEEILV TVGGYGSLFN AIQGLVDPGD EVIIMVPFYD CYEPMVKMAG AVPVFIPLRS 190 200 210 220 230 240 KRTDGMKWTS SDWTFNPQEL ESKFSSKTKA IILNTPHNPI GKVYTREELQ VIADLCIKHD 250 260 270 280 290 300 TLCISDEVYE WLVYTGHKHI KVASLPGMWD RTLTIGSAGK TFSVTGWKLG WSIGPGHLIK 310 320 330 340 350 360 HLRTVQQTSV YTCATPLQAA LAEAFWIDIK RMDDPECYFN SLPKELEVKR DRMACLLNSV 370 380 390 400 410 420 GLKPIIPDGG YFIIADVSSL GVDLSDVKSD EPYDYKFVKW MTKNKKLSAI PVSAFCDSES 430 440 450 KPHFEKLVRF CFIKKDSTLD AAEEIFRTWN SRKS

References

[1]	"Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family." Yu P., Li Z., Zhang L., Tagle D.A., Cai T. Gene 365:111-118(2006) [PubMed: 16376499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY955395 mRNA. Translation: AAX55607.1.
IPI	IPI00564133.
RefSeq	NP_001015037.1.
UniGene	Rn.28263
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	541589.
KEGG	rno:541589.
Organism-specific databases
CTD	541589.
RGD	1359262. Kat3.
Phylogenomic databases
HOVERGEN	Q58FK9.
Enzyme and pathway databases
BRENDA	2.6.1.7. 248. 4.4.1.13. 248.
Gene expression databases
Genevestigator	Q58FK9.
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotransferase_I/II. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
ProtoNet	Search...
Other Resources
NextBio	714083.

Entry information

Entry name

KAT3_RAT

Accession

Primary (citable) accession number: Q58FK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	April 26, 2005
Last modified:	October 13, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)