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Protein

Putative heat shock protein HSP 90-beta 2

Gene

HSP90AB2P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461ATPBy similarity
Binding sitei88 – 881ATPBy similarity
Binding sitei107 – 1071ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative heat shock protein HSP 90-beta 2
Alternative name(s):
Heat shock protein 90-beta b
Short name:
Heat shock protein 90Bb
Gene namesi
Name:HSP90AB2P
Synonyms:HSP90BB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:32537. HSP90AB2P.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi190359598.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Putative heat shock protein HSP 90-beta 2PRO_0000340659Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei177 – 1771PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ58FF8.
MaxQBiQ58FF8.
PeptideAtlasiQ58FF8.
PRIDEiQ58FF8.

PTM databases

iPTMnetiQ58FF8.
PhosphoSiteiQ58FF8.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ58FF8. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ58FF8.
SMRiQ58FF8. Positions 8-155, 206-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili315 – 34733Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi185 – 19713Poly-LysAdd
BLAST

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG007374.
InParanoidiQ58FF8.
PhylomeDBiQ58FF8.

Family and domain databases

Gene3Di3.30.565.10. 3 hits.
InterProiIPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 2 hits.
[Graphical view]
PRINTSiPR00775. HEATSHOCK90.
SUPFAMiSSF54211. SSF54211. 2 hits.
SSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58FF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEEVHLGEK EVETFAFQAE IAQLMSLIIN TFYSNKEIFL WELISNASDA
60 70 80 90 100
LDKIRYESLT DPSKLDSGKE LKIDIIPNTQ EHTLTLVDTG IGMTKADLIN
110 120 130 140 150
NLGTIAKFQD QTEYLEEMQV KEVVEKHSQF LGYPITLYLE KEREKEISDG
160 170 180 190 200
KAEEEKGEKE EENKDDEEKP KIEDVGSDEE DDSGKDKKKK TKKIKEKYID
210 220 230 240 250
QEELNKTKPI WTRNTEDITQ EEYGEFYKSL TNDWKDHLAV RYFSVEEYVS
260 270 280 290 300
RMKEIQKSIY YITGESKEQV ANSAFVEQVW KRDSRVVYMT EPIDGYQLKE
310 320 330 340 350
FDGKSLVSVT KEGLELPEDG EEKKRMEERK AKFENLCKFM KETLDKKVEM
360 370 380
VTVSNRLVSS SCCIVTSTYS WTANMEQIMK A
Length:381
Mass (Da):44,349
Last modified:June 10, 2008 - v2
Checksum:iB8F6A86959E30905
GO

Sequence cautioni

The sequence AAX38250.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY956763 mRNA. Translation: AAX38250.1. Different initiation.
UniGeneiHs.590925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY956763 mRNA. Translation: AAX38250.1. Different initiation.
UniGeneiHs.590925.

3D structure databases

ProteinModelPortaliQ58FF8.
SMRiQ58FF8. Positions 8-155, 206-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ58FF8. 5 interactions.

PTM databases

iPTMnetiQ58FF8.
PhosphoSiteiQ58FF8.

Polymorphism and mutation databases

DMDMi190359598.

Proteomic databases

EPDiQ58FF8.
MaxQBiQ58FF8.
PeptideAtlasiQ58FF8.
PRIDEiQ58FF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiHSP90AB2P.
HGNCiHGNC:32537. HSP90AB2P.
neXtProtiNX_Q58FF8.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG007374.
InParanoidiQ58FF8.
PhylomeDBiQ58FF8.

Miscellaneous databases

PROiQ58FF8.

Family and domain databases

Gene3Di3.30.565.10. 3 hits.
InterProiIPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 2 hits.
[Graphical view]
PRINTSiPR00775. HEATSHOCK90.
SUPFAMiSSF54211. SSF54211. 2 hits.
SSF55874. SSF55874. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The HSP90 family of genes in the human genome: insights into their divergence and evolution."
    Chen B., Piel W.H., Gui L., Bruford E., Monteiro A.
    Genomics 86:627-637(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE.
  2. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiH90B2_HUMAN
AccessioniPrimary (citable) accession number: Q58FF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 11, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.