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Protein

Putative heat shock protein HSP 90-beta-3

Gene

HSP90AB3P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461ATPBy similarity
Binding sitei88 – 881ATPBy similarity
Binding sitei107 – 1071ATPBy similarity
Binding sitei334 – 3341ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative heat shock protein HSP 90-beta-3
Alternative name(s):
Heat shock protein 90-beta c
Short name:
Heat shock protein 90Bc
Gene namesi
Name:HSP90AB3P
Synonyms:HSP90BC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5259. HSP90AB3P.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74722492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597Putative heat shock protein HSP 90-beta-3PRO_0000336047Add
BLAST

Proteomic databases

EPDiQ58FF7.
MaxQBiQ58FF7.
PRIDEiQ58FF7.
TopDownProteomicsiQ58FF7.

Expressioni

Organism-specific databases

HPAiHPA055729.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ58FF7. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ58FF7.
SMRiQ58FF7. Positions 8-200, 240-562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili414 – 44633Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi593 – 5975TPR repeat-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi289 – 2924Poly-Lys

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG007374.
InParanoidiQ58FF7.
PhylomeDBiQ58FF7.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 3 hits.
[Graphical view]
PRINTSiPR00775. HEATSHOCK90.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58FF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEEVHHGEE EVETFAFQAE IAQLISLIIN TFYSNEEIFL QELISNASDA
60 70 80 90 100
LDKIRYESLT DPSKLDSGKE LKIDIIPNPQ ERTLALVDTG IGMTKADLIN
110 120 130 140 150
NLRTIAKSGT KACMEALQAE KLVVITKHND DEQYAWESSA GGSFTVHADH
160 170 180 190 200
GEPIGRGTKV ILHLKEDQTE YLEERRVKEV VKKHSQFIGY PITLYLEKEQ
210 220 230 240 250
DKEISDDEAE EEKGEKEEED KDDEEKPKIK DVGSDEEDDS KEYGEFYKSL
260 270 280 290 300
TSDWEDHLAV KHFSVEGQLE FRALLFSPRR APFDLFENKK KKNNIKLYVR
310 320 330 340 350
RVFIMDSCDE LIPEYLNFIH GVVDSEDLPL NISREMLQQS KILKYVSHMK
360 370 380 390 400
ETQKSTYYIT GESKEQVANS AFVERVRKQG FEVVYMTEPI DEYCVQQLKE
410 420 430 440 450
FDGKSLVSVT KEGLELPEDE EEKKKMEESK EKFENLCKLM KEILDKKVEK
460 470 480 490 500
VTISNRLVSS PCCIVTSTYG WTANMEQIMK AQALRDNSTM GYMMAKKHLE
510 520 530 540 550
INPDHPIMET LRQKAEADKN DKAVKDLVVL LFETALLSSG FSLEDPQTHS
560 570 580 590
NHIYHMIKLG LGTDEDEVAA EEPSDAVPDE IPPLEGDEDA SRMEEVD
Length:597
Mass (Da):68,325
Last modified:April 26, 2005 - v1
Checksum:i9DA27E4F47CA6949
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY956764 mRNA. Translation: AAX38251.1.
UniGeneiHs.744112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY956764 mRNA. Translation: AAX38251.1.
UniGeneiHs.744112.

3D structure databases

ProteinModelPortaliQ58FF7.
SMRiQ58FF7. Positions 8-200, 240-562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ58FF7. 3 interactions.

Polymorphism and mutation databases

DMDMi74722492.

Proteomic databases

EPDiQ58FF7.
MaxQBiQ58FF7.
PRIDEiQ58FF7.
TopDownProteomicsiQ58FF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiHSP90AB3P.
HGNCiHGNC:5259. HSP90AB3P.
HPAiHPA055729.
neXtProtiNX_Q58FF7.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG007374.
InParanoidiQ58FF7.
PhylomeDBiQ58FF7.

Miscellaneous databases

PROiQ58FF7.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 3 hits.
[Graphical view]
PRINTSiPR00775. HEATSHOCK90.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The HSP90 family of genes in the human genome: insights into their divergence and evolution."
    Chen B., Piel W.H., Gui L., Bruford E., Monteiro A.
    Genomics 86:627-637(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiH90B3_HUMAN
AccessioniPrimary (citable) accession number: Q58FF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 26, 2005
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.