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Protein

Putative heat shock protein HSP 90-beta-3

Gene

HSP90AB3P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46ATPBy similarity1
Binding sitei88ATPBy similarity1
Binding sitei107ATPBy similarity1
Binding sitei334ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative heat shock protein HSP 90-beta-3
Alternative name(s):
Heat shock protein 90-beta c
Short name:
Heat shock protein 90Bc
Gene namesi
Name:HSP90AB3P
Synonyms:HSP90BC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5259. HSP90AB3P.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74722492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003360471 – 597Putative heat shock protein HSP 90-beta-3Add BLAST597

Proteomic databases

EPDiQ58FF7.
MaxQBiQ58FF7.
PeptideAtlasiQ58FF7.
PRIDEiQ58FF7.
TopDownProteomicsiQ58FF7.

PTM databases

iPTMnetiQ58FF7.
PhosphoSitePlusiQ58FF7.
SwissPalmiQ58FF7.

Expressioni

Organism-specific databases

HPAiHPA055729.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ58FF7. 4 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ58FF7.
SMRiQ58FF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili414 – 446Sequence analysisAdd BLAST33

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi593 – 597TPR repeat-binding5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi289 – 292Poly-Lys4

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG007374.
InParanoidiQ58FF7.
PhylomeDBiQ58FF7.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiView protein in Pfam
PF02518. HATPase_c. 1 hit.
PF00183. HSP90. 3 hits.
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58FF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEEVHHGEE EVETFAFQAE IAQLISLIIN TFYSNEEIFL QELISNASDA
60 70 80 90 100
LDKIRYESLT DPSKLDSGKE LKIDIIPNPQ ERTLALVDTG IGMTKADLIN
110 120 130 140 150
NLRTIAKSGT KACMEALQAE KLVVITKHND DEQYAWESSA GGSFTVHADH
160 170 180 190 200
GEPIGRGTKV ILHLKEDQTE YLEERRVKEV VKKHSQFIGY PITLYLEKEQ
210 220 230 240 250
DKEISDDEAE EEKGEKEEED KDDEEKPKIK DVGSDEEDDS KEYGEFYKSL
260 270 280 290 300
TSDWEDHLAV KHFSVEGQLE FRALLFSPRR APFDLFENKK KKNNIKLYVR
310 320 330 340 350
RVFIMDSCDE LIPEYLNFIH GVVDSEDLPL NISREMLQQS KILKYVSHMK
360 370 380 390 400
ETQKSTYYIT GESKEQVANS AFVERVRKQG FEVVYMTEPI DEYCVQQLKE
410 420 430 440 450
FDGKSLVSVT KEGLELPEDE EEKKKMEESK EKFENLCKLM KEILDKKVEK
460 470 480 490 500
VTISNRLVSS PCCIVTSTYG WTANMEQIMK AQALRDNSTM GYMMAKKHLE
510 520 530 540 550
INPDHPIMET LRQKAEADKN DKAVKDLVVL LFETALLSSG FSLEDPQTHS
560 570 580 590
NHIYHMIKLG LGTDEDEVAA EEPSDAVPDE IPPLEGDEDA SRMEEVD
Length:597
Mass (Da):68,325
Last modified:April 26, 2005 - v1
Checksum:i9DA27E4F47CA6949
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY956764 mRNA. Translation: AAX38251.1.
UniGeneiHs.744112.

Similar proteinsi

Entry informationi

Entry nameiH90B3_HUMAN
AccessioniPrimary (citable) accession number: Q58FF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 26, 2005
Last modified: August 30, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families