ID   ENPLL_HUMAN             Reviewed;         399 AA.
AC   Q58FF3;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   RecName: Full=Putative endoplasmin-like protein;
DE   AltName: Full=Putative heat shock protein 90 kDa beta member 2;
GN   Name=HSP90B2P; Synonyms=GRP94B, GRP94P1, TRAP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16269234; DOI=10.1016/j.ygeno.2005.08.012;
RA   Chen B., Piel W.H., Gui L., Bruford E., Monteiro A.;
RT   "The HSP90 family of genes in the human genome: insights into their
RT   divergence and evolution.";
RL   Genomics 86:627-637(2005).
RN   [2]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-130, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033;
RA   Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V.,
RA   Vertegaal A.C.;
RT   "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.";
RL   Cell Rep. 10:1778-1791(2015).
CC   -!- FUNCTION: Putative molecular chaperone. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 90 family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AY956768; AAX38255.1; -; mRNA.
DR   AlphaFoldDB; Q58FF3; -.
DR   SMR; Q58FF3; -.
DR   IntAct; Q58FF3; 6.
DR   GlyGen; Q58FF3; 1 site.
DR   iPTMnet; Q58FF3; -.
DR   PhosphoSitePlus; Q58FF3; -.
DR   SwissPalm; Q58FF3; -.
DR   BioMuta; HGNC:12099; -.
DR   DMDM; 74706932; -.
DR   EPD; Q58FF3; -.
DR   jPOST; Q58FF3; -.
DR   MassIVE; Q58FF3; -.
DR   MaxQB; Q58FF3; -.
DR   PeptideAtlas; Q58FF3; -.
DR   ProteomicsDB; 62620; -.
DR   AGR; HGNC:12099; -.
DR   GeneCards; HSP90B2P; -.
DR   HGNC; HGNC:12099; HSP90B2P.
DR   neXtProt; NX_Q58FF3; -.
DR   InParanoid; Q58FF3; -.
DR   PhylomeDB; Q58FF3; -.
DR   PathwayCommons; Q58FF3; -.
DR   SignaLink; Q58FF3; -.
DR   Pharos; Q58FF3; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q58FF3; Protein.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   Gene3D; 3.30.230.80; -; 1.
DR   Gene3D; 3.40.50.11260; -; 2.
DR   Gene3D; 1.20.120.790; Heat shock protein 90, C-terminal domain; 1.
DR   InterPro; IPR037196; HSP90_C.
DR   InterPro; IPR001404; Hsp90_fam.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   PANTHER; PTHR11528:SF139; ENDOPLASMIN-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR   Pfam; PF00183; HSP90; 1.
DR   SUPFAM; SSF110942; HSP90 C-terminal domain; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00014; ER_TARGET; 1.
PE   5: Uncertain;
KW   Chaperone; Isopeptide bond; Reference proteome; Stress response;
KW   Ubl conjugation.
FT   CHAIN           1..399
FT                   /note="Putative endoplasmin-like protein"
FT                   /id="PRO_0000349258"
FT   REGION          350..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        368..399
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        130
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:25772364"
SQ   SEQUENCE   399 AA;  45859 MW;  8DB8E2D7E202E3CE CRC64;
     MAETIQEVED EYKAFCKSFS KESDDPVACI HFTAEGEVTF KSILFVPTFV PRGLFDEYGS
     KKSDYIKLYV RCVFITDDFR DTMPKNLNFV KGVVDSGGLS LNVSCETLQQ HKLLKVIRKK
     LVHKTLDMIK KIADEKYNDT FWKEFGTNIK LGVIEDHSNR TCLAKLLRFQ SSHHPADITS
     LHQDVERMKE KQDKICLMAG GYEVIYLTEP VVEYCIQALP EFDGKRFQNV AKEGVKFDDS
     EKTKESHEAV EKEFEPLPNW VKDKAIKDKI EKAMVSQCLT ESLCALVASQ YGWSGNMERI
     MKAQAYQTGK GISTNYHASR KKTFEINPRH PLIRDMLRRI KEDEDDKTVL DLAVVEEPDE
     EPEETAEDKE QDKDKEMDVG TDEEKQETAK ESTAEKDEL
//